| URN | urn:agi-llid:23118 |
|---|---|
| Total Entities | 0 |
| Connectivity | 139 |
| Name | Tab2 |
| Description | TGF-beta activated kinase 1/MAP3K7 binding protein 2 |
| Notes | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | K63-linked polyubiquitin binding |
|---|---|
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | endosome membrane |
|---|---|
| nucleoplasm | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| activation of MAPK activity | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| positive regulation of protein kinase activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| innate immune response | |
| heart development |
| Pathway | NOD-like receptor signaling pathway |
|---|---|
| nuclear factor kappa B signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| activation of MAPK activity | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| positive regulation of protein kinase activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| innate immune response | |
| heart development | |
| K63-linked polyubiquitin binding | |
| metal ion binding | |
| zinc ion binding | |
| endosome membrane | |
| nucleoplasm | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 23118 |
|---|
| Hugo ID | 17075 |
|---|
| Human chromosome position | 6q25.1 |
|---|
| LocusLink ID | 23118 |
|---|---|
| 68652 | |
| 308267 |
| Alias | CHTD2 |
|---|---|
| MAP3K7IP2 | |
| TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | |
| TAB-2 | |
| TAK1-binding protein 2 | |
| TGF-beta-activated kinase 1-binding protein 2 | |
| mitogen-activated protein kinase kinase kinase 7-interacting protein 2 | |
| mKIAA0733 | |
| 1110030N06Rik | |
| A530078N03Rik | |
| Tak1 binding protein 2 | |
| mitogen activated protein kinase kinase kinase 7 interacting protein 2 | |
| mitogen-activated protein kinase kinase kinase 7 interacting protein 2 | |
| OTTHUMP00000040125 | |
| OTTMUSP00000046773 | |
| TAB2 | |
| TAK1-binding protein II | |
| OTTHUMP00000017388 | |
| TGF-beta activated kinase 1/MAP3K7 binding protein 2 | |
| A530078N03 | |
| KIAA0733 | |
| mitogen-activated protein kinase kinase kinase 7 interacting protein II | |
| mitogen-activated protein kinase kinase kinase 7 interactive protein 2 | |
| mitogen-activated protein kinase kinase kinase 7 interactive protein II | |
| 1110030N06 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605101 |
|---|---|
| 612863 |
| Unigene ID | Hs.269775 |
|---|---|
| Mm.193041 | |
| Rn.231700 |
| KEGG ID | hsa:23118 |
|---|---|
| mmu:68652 | |
| rno:308267 |
| Swiss-Prot Accession | B4DIR9 |
|---|---|
| Q9NYJ8 | |
| Q99K90 | |
| Q5U303 | |
| B2RCC4 | |
| E1P5A0 | |
| O94838 | |
| Q6I9W8 | |
| Q76N06 | |
| Q9UFP7 | |
| Q3UGP1 | |
| Q8BTP4 | |
| Q8CHD3 | |
| Q99KP4 |
| GO ID | 0070530 |
|---|---|
| 0008270 | |
| 0007249 | |
| 0007254 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0007507 | |
| 0045087 | |
| 0035872 | |
| 0070423 | |
| 0043123 | |
| 0051092 | |
| 0045860 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0005829 | |
| 0010008 | |
| 0005886 | |
| 0046872 | |
| 0005737 | |
| 0005622 | |
| 0005634 | |
| 0005654 |
| PIR ID | T17217 |
|---|
| Swiss-Prot ID | TAB2_RAT |
|---|---|
| TAB2_HUMAN | |
| TAB2_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| cytosol | |
| Membrane |
| IPI ID | IPI00213030 |
|---|---|
| IPI00734571 | |
| IPI00157561 | |
| IPI00419504 | |
| IPI00115639 |
| Mouse chromosome position | 10 |
|---|
| Rat chromosome position | 1p13 |
|---|
| Homologene ID | 9019 |
|---|
| MGI ID | 1915902 |
|---|
| RGD ID | 1309527 |
|---|