| URN | urn:agi-llid:1147 |
|---|---|
| Total Entities | 0 |
| Connectivity | 734 |
| Name | Chuk |
| Description | conserved helix-loop-helix ubiquitous kinase (predicted) |
| Notes | This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. |
| Ariadne Ontology | IKBK |
|---|---|
| Secreted proteins |
| GO Molecular Function | protein heterodimerization activity |
|---|---|
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| IkappaB kinase activity | |
| receptor signaling protein serine-threonine kinase activity |
| GO Cellular Component | nucleolus |
|---|---|
| CD40 receptor complex | |
| internal side of plasma membrane | |
| IkappaB kinase complex | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | response to virus |
|---|---|
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| signal transduction by phosphorylation | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| Rho protein signal transduction | |
| phosphatidylinositol-mediated signaling | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of NF-kappaB transcription factor activity | |
| osteoclast differentiation | |
| striated muscle cell differentiation | |
| protein phosphorylation | |
| I-kappaB phosphorylation | |
| phosphorylation | |
| immune response | |
| innate immune response | |
| mammary gland epithelial cell proliferation | |
| response to organic substance | |
| response to hydroperoxide | |
| response to drug | |
| response to toxin | |
| response to acid | |
| response to amino acid stimulus | |
| response to lipopolysaccharide | |
| inflammatory response | |
| positive regulation of type I interferon production | |
| anatomical structure morphogenesis | |
| mammary gland alveolus development | |
| morphogenesis of an epithelial sheet | |
| odontogenesis of dentin-containing tooth | |
| skeletal muscle contraction | |
| lactation |
| Pathway | Histone Phosphorylation |
|---|---|
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | IKBK |
|---|---|
| response to virus | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| signal transduction by phosphorylation | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| Rho protein signal transduction | |
| phosphatidylinositol-mediated signaling | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of NF-kappaB transcription factor activity | |
| osteoclast differentiation | |
| striated muscle cell differentiation | |
| protein phosphorylation | |
| I-kappaB phosphorylation | |
| phosphorylation | |
| immune response | |
| innate immune response | |
| mammary gland epithelial cell proliferation | |
| response to organic substance | |
| response to hydroperoxide | |
| response to drug | |
| response to toxin | |
| response to acid | |
| response to amino acid stimulus | |
| response to lipopolysaccharide | |
| inflammatory response | |
| positive regulation of type I interferon production | |
| anatomical structure morphogenesis | |
| mammary gland alveolus development | |
| morphogenesis of an epithelial sheet | |
| odontogenesis of dentin-containing tooth | |
| skeletal muscle contraction | |
| lactation | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| IkappaB kinase activity | |
| receptor signaling protein serine-threonine kinase activity | |
| nucleolus | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| IkappaB kinase complex | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 1147 |
|---|
| Hugo ID | 1974 |
|---|
| Human chromosome position | 10q24-q25 |
|---|
| LocusLink ID | 1147 |
|---|---|
| 12675 | |
| 309361 | |
| 107137 | |
| 281073 | |
| 393287 |
| Alias | IKK1 |
|---|---|
| IKKA | |
| IKBKA | |
| TCF16 | |
| NFKBIKA | |
| IKK-alpha | |
| inhibitor of nuclear factor kappa-B kinase subunit alpha | |
| TCF-16 | |
| IKK-a kinase | |
| I-kappa-B kinase 1 | |
| I-kappa-B kinase-alpha | |
| transcription factor 16 | |
| IkB kinase alpha subunit | |
| Nuclear factor NFkappaB inhibitor kinase alpha | |
| Chuk1 | |
| Fbx24 | |
| Fbxo24 | |
| AI256658 | |
| IKK-A | |
| IKK alpha | |
| I kappa B kinase 1 | |
| IkappaB kinase alpha | |
| I-kappa-B kinase alpha | |
| nuclear factor NF-kappa-B inhibitor kinase alpha | |
| OTTMUSP00000038221 | |
| Inhibitor of nuclear factor kappa-B kinase alpha subunit | |
| MGC25325 | |
| NFKBIKAs | |
| OTTHUMP00000020273 | |
| Conserved helix-loop-helix ubiquitous kinase | |
| IKK[a] | |
| CHUK | |
| Chuk I | |
| conserved helix-loop ubiquitous kinase | |
| I kappaB kinase 1 | |
| I kappaB kinase alpha | |
| I kappaB kinase I | |
| IKK 1 | |
| ikappaB kinase | |
| IKK-1 | |
| IKKalpha | |
| Conserved helix-loop-helix ubiquitous kinase | |
| conserved helix-loop-helix ubiquitous kinase (predicted) | |
| similar to conserved helix-loop-helix ubiquitous kinase | |
| MGC56539 | |
| chromosome | |
| scaffold | |
| zgc:56539 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio | |
| Human |
| OMIM ID | 600664 |
|---|---|
| 613630 | |
| OMIM:600664 |
| Unigene ID | Hs.198998 |
|---|---|
| Mm.3996 | |
| Rn.23019 | |
| Mm.428277 | |
| Bt.63925 | |
| Dr.14012 | |
| Mm.462188 |
| KEGG ID | hsa:1147 |
|---|---|
| mmu:12675 | |
| rno:309361 |
| Swiss-Prot Accession | O15111 |
|---|---|
| E9Q605 | |
| Q3TPN9 | |
| Q8CBT3 | |
| E9QNL4 | |
| Q3UDK0 | |
| Q60680 | |
| G3V926 | |
| O14666 | |
| Q13132 | |
| Q5W0I4 | |
| Q92467 | |
| Q562E6 | |
| Q59GT1 | |
| A0AUV3 | |
| Q3U2A3 | |
| Q3U2E5 |
| EC Number | 2.7.11.10 |
|---|---|
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0008384 | |
| 0004672 | |
| 0007249 | |
| 0007252 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0009653 | |
| 0007173 | |
| 0008543 | |
| 0006955 | |
| 0006954 | |
| 0045087 | |
| 0007595 | |
| 0060749 | |
| 0033598 | |
| 0002011 | |
| 0048011 | |
| 0035872 | |
| 0070423 | |
| 0042475 | |
| 0030316 | |
| 0048015 | |
| 0043123 | |
| 0051092 | |
| 0032481 | |
| 0006468 | |
| 0009615 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0035631 | |
| 0008385 | |
| 0005737 | |
| 0005829 | |
| 0009898 | |
| 0043231 | |
| 0005730 | |
| 0005634 | |
| 0016301 | |
| 0000166 | |
| 0046982 | |
| 0004674 | |
| 0004702 | |
| 0016740 | |
| 0016772 | |
| 0007266 | |
| 0016310 | |
| 0032496 | |
| 0010033 | |
| 0023014 | |
| 0051146 | |
| 0001101 | |
| 0043200 | |
| 0042493 | |
| 0033194 | |
| 0009636 | |
| 0003009 | |
| 0005792 | |
| 0042802 | |
| 0005515 | |
| 0004713 | |
| 0001757 | |
| 0005575 | |
| 0007417 | |
| 0043066 | |
| 0043124 |
| Swiss-Prot ID | IKKA_HUMAN |
|---|---|
| Q8CBT3_MOUSE | |
| Q3TPN9_MOUSE | |
| Q3UDK0_MOUSE | |
| IKKA_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00005104 |
|---|---|
| IPI00119213 | |
| IPI00400114 | |
| IPI00230069 | |
| IPI00388641 | |
| IPI00561124 |
| Mouse chromosome position | 19 45.0 cM |
|---|
| Rat chromosome position | 1q54 |
|---|
| Homologene ID | 979 |
|---|
| MGI ID | 99484 |
|---|---|
| 2147493 |
| RGD ID | 1306661 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 10q24-q25 |
|---|
| Microarray ID | 99070_at |
|---|---|
| 1384006_at | |
| 102434_r_at | |
| 1417091_at | |
| 1428210_s_at | |
| 1451383_a_at | |
| u12473_s_at | |
| A_51_P223475 | |
| 33770_at | |
| 209666_s_at | |
| AA403202_at | |
| RC_AA398648_at | |
| A_23_P46748 | |
| A_14_P101437 | |
| A_14_P134389 | |
| A_14_P138752 |
| FunctionalClass | ATP binding |
|---|---|
| IkappaB kinase | |
| nucleotide binding | |
| protein binding | |
| protein serine/threonine kinase | |
| transferase | |
| kinase | |
| protein kinase | |
| protein-tyrosine kinase | |
| receptor signaling protein serine/threonine kinase |
| Mus musculus Chromosome position | 19 45.0 cM |
|---|---|
| 19 |
| KEGG pathway | Apoptosis |
|---|---|
| B cell receptor signaling pathway | |
| MAPK signaling pathway | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Adipocytokine signaling pathway | |
| Chronic myeloid leukemia | |
| Pancreatic cancer | |
| Small cell lung cancer | |
| Prostate cancer |
| Rattus norvegicus Chromosome position | 1q54 |
|---|
| Bos taurus Chromosome position | 26 |
|---|