Elsevier Inc. Nfkb2 RELB K63-ubiquitin M1-Ubiquitin M1-ubiquitination miRNA in NF-kB LUBAC complex SCF ubiquitin ligase complex K63-polyubiquitination NF-kB target genes Tnf receptor superfamily, other upstream activators adapters adapters ---- Ikbkg adapters --+> Map3k14 SCF ubiquitin ligase complex ---| Nfkbia Rel Map3k14 --+> Chuk Chuk Map3k14 Ikbkb ---> Nfkbia Ikbkb ---> Nfkbib Ikbkb ---> Nfkbie Nfkbia Ikbkb Nfkbib K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Ikbkg ---- K63-ubiquitin Ikbkg Map3k7 Nfkbie Ikbkb ---- Ikbkg Ikbkg ---- M1-Ubiquitin Nfkbia ---- Rela Nfkbia ---| Rela Nfkb1 ---- Nfkbia Nfkbib ---- Rela Nfkbib ---| Rela Chuk ---- Ikbkg SCF ubiquitin ligase complex ---| Nfkbib SCF ubiquitin ligase complex ---| Nfkbie Chuk ---- Ikbkb Chuk --+> Nfkb2 NF-kB target genes ---> Nfkbia Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb1 ---> NF-kB target genes Rel ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes miRNA in NF-kB ---> NF-kB target genes NF-kB target genes ---> miRNA in NF-kB Rela Nfkb1 Map3k7 --+> Ikbkb LUBAC complex ---> Ikbkg Cyld Tab2 Tab3 Tab1 Cyld ---| K63-polyubiquitination adapters --+> Map3k7 Cyld ---| Map3k7