| URN | urn:agi-llid:114131 |
|---|---|
| Connectivity | 58 |
| Name | Ucn3 |
| Description | urocortin 3 (stresscopin) |
| Notes | This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq] |
| Pathway | corticotropin-releasing hormone signaling pathway |
|---|
| GO Molecular Function | hormone activity |
|---|---|
| neuropeptide hormone activity |
| GO Cellular Component | extracellular region |
|---|---|
| neuron projection | |
| varicosity | |
| axon |
| GO Biological Process | response to stress |
|---|---|
| cellular response to nutrient levels | |
| positive regulation of insulin secretion | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| response to hypoxia | |
| response to starvation | |
| response to corticosterone stimulus | |
| response to glucose stimulus | |
| neuropeptide signaling pathway |
| Ariadne Ontology | Neuromodulator |
|---|
| Group | Neuromodulator |
|---|---|
| extracellular region | |
| response to stress | |
| cellular response to nutrient levels | |
| positive regulation of insulin secretion | |
| activation of adenylate cyclase activity by G-protein signaling pathway | |
| response to hypoxia | |
| response to starvation | |
| response to corticosterone stimulus | |
| response to glucose stimulus | |
| neuropeptide signaling pathway | |
| hormone activity | |
| neuropeptide hormone activity | |
| neuron projection | |
| varicosity | |
| axon |
| MedScan ID | 114131 |
|---|
| Hugo ID | 17781 |
|---|
| Human chromosome position | 10p15.1 |
|---|
| LocusLink ID | 114131 |
|---|---|
| 83428 | |
| 498791 |
| Alias | SCP |
|---|---|
| SPC | |
| UCNIII | |
| MGC119002 | |
| urocortin-3 | |
| ucn III | |
| stresscopin | |
| urocortin III | |
| Urocortin II | |
| RGD1562213 | |
| OTTHUMP00000018999 | |
| UCN3 | |
| urocortin 3 | |
| urocortin 3 (stresscopin) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605901 |
|---|
| Mouse chromosome position | 13 |
|---|
| GO ID | 0005179 |
|---|---|
| 0007189 | |
| 0031669 | |
| 0032024 | |
| 0051412 | |
| 0009749 | |
| 0001666 | |
| 0042594 | |
| 0030424 | |
| 0005576 | |
| 0043196 | |
| 0005184 | |
| 0007218 | |
| 0043005 | |
| 0006950 |
| Rat chromosome position | 17q12.3 |
|---|
| Swiss-Prot Accession | Q969E3 |
|---|---|
| Q0VDY5 | |
| Q3UFJ9 | |
| Q924A4 | |
| A1YKY5 | |
| Q496H2 | |
| Q5SR91 |
| Unigene ID | Hs.511775 |
|---|---|
| Mm.313662 | |
| Rn.141298 |
| KEGG ID | hsa:114131 |
|---|---|
| mmu:83428 | |
| rno:498791 |
| Swiss-Prot ID | UCN3_HUMAN |
|---|---|
| UCN3_MOUSE | |
| Q3UFJ9_MOUSE | |
| Q0VDY5_MOUSE | |
| A1YKY5_RAT | |
| Q5SR91_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00056311 |
|---|---|
| IPI00125318 | |
| IPI00191388 |
| Homologene ID | 49959 |
|---|
| RGD ID | 1562213 |
|---|
| MGI ID | 1932970 |
|---|