| URN | urn:agi-llid:7349 |
|---|---|
| Connectivity | 301 |
| Name | Ucn |
| Description | urocortin |
| Notes | This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq] |
| Pathway | corticotropin-releasing hormone signaling pathway |
|---|
| GO Molecular Function | hormone activity |
|---|---|
| G-protein-coupled receptor binding | |
| neuropeptide hormone activity |
| GO Cellular Component | extracellular region |
|---|---|
| neuronal cell body | |
| axon terminus | |
| axon | |
| dendrite |
| GO Biological Process | female pregnancy |
|---|---|
| positive regulation of vasodilation | |
| positive regulation of interleukin-6 production | |
| positive regulation of collagen biosynthetic process | |
| regulation of synaptic transmission, glutamatergic | |
| pancreatic juice secretion | |
| learning or memory | |
| positive regulation of cell growth | |
| neuron projection development | |
| positive regulation of translation | |
| positive regulation of DNA replication | |
| neuroprotection | |
| response to oxidative stress | |
| feeding behavior | |
| response to estradiol stimulus | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| drinking behavior | |
| G-protein coupled receptor protein signaling pathway | |
| neuropeptide signaling pathway | |
| negative regulation of blood pressure |
| Ariadne Ontology | Neuromodulator |
|---|
| Group | Neuromodulator |
|---|---|
| extracellular region | |
| female pregnancy | |
| positive regulation of vasodilation | |
| positive regulation of interleukin-6 production | |
| positive regulation of collagen biosynthetic process | |
| regulation of synaptic transmission, glutamatergic | |
| pancreatic juice secretion | |
| learning or memory | |
| positive regulation of cell growth | |
| neuron projection development | |
| positive regulation of translation | |
| positive regulation of DNA replication | |
| neuroprotection | |
| response to oxidative stress | |
| feeding behavior | |
| response to estradiol stimulus | |
| response to glucocorticoid stimulus | |
| inflammatory response | |
| drinking behavior | |
| G-protein coupled receptor protein signaling pathway | |
| neuropeptide signaling pathway | |
| negative regulation of blood pressure | |
| hormone activity | |
| G-protein-coupled receptor binding | |
| neuropeptide hormone activity | |
| neuronal cell body | |
| axon terminus | |
| axon | |
| dendrite |
| MedScan ID | 7349 |
|---|
| Hugo ID | 12516 |
|---|
| Human chromosome position | 2p23-p21 |
|---|
| LocusLink ID | 7349 |
|---|---|
| 22226 | |
| 29151 |
| Alias | UI |
|---|---|
| UROC | |
| MGC129974 | |
| MGC129975 | |
| urocortin | |
| urocortin, preproprotein | |
| Ucn1 | |
| Mpv17 | |
| MGC151325 | |
| MGC151327 | |
| OTTMUSP00000025608 | |
| corticotensin | |
| urocortin 1 | |
| urocortin I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600945 |
|---|
| Mouse chromosome position | 5 18.0 cM |
|---|
| GO ID | 0001664 |
|---|---|
| 0005184 | |
| 0007186 | |
| 0042756 | |
| 0007565 | |
| 0006954 | |
| 0007611 | |
| 0045776 | |
| 0031175 | |
| 0007218 | |
| 0043526 | |
| 0030157 | |
| 0045740 | |
| 0030307 | |
| 0032967 | |
| 0032755 | |
| 0045727 | |
| 0045909 | |
| 0051966 | |
| 0032355 | |
| 0051384 | |
| 0006979 | |
| 0030424 | |
| 0043679 | |
| 0030425 | |
| 0005576 | |
| 0043025 | |
| 0005179 | |
| 0007631 |
| Rat chromosome position | 6q14 |
|---|
| Swiss-Prot Accession | P55089 |
|---|---|
| P81615 | |
| Q14A76 | |
| Q9QX20 | |
| P55090 | |
| O88390 | |
| Q6FG64 |
| PIR ID | S60262 |
|---|
| Unigene ID | Hs.534363 |
|---|---|
| Mm.377116 | |
| Rn.10190 |
| KEGG ID | hsa:7349 |
|---|---|
| mmu:22226 | |
| rno:29151 |
| Swiss-Prot ID | UCN1_MOUSE |
|---|---|
| UCN1_RAT | |
| UCN1_HUMAN | |
| Q14A76_MOUSE |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00123680 |
|---|---|
| IPI00213597 | |
| IPI00022801 | |
| IPI00554995 |
| Homologene ID | 2515 |
|---|
| RGD ID | 3929 |
|---|
| MGI ID | 1276123 |
|---|