| URN | urn:agi-llid:1395 |
|---|---|
| Connectivity | 134 |
| Name | Crhr2 |
| Description | corticotropin releasing hormone receptor 2 |
| Notes | Liaw et al. (1996) [PubMed 8536644] stated that there are 2 G protein-coupled corticotropin-releasing hormone (CRH; MIM 122560) receptors, CRHR1 (MIM 122561) and CRHR2, which they termed the CRF2 receptor. CRH is a 41-amino acid peptide synthesized in the hypothalamus that is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge.[supplied by OMIM] |
| Pathway | corticotropin-releasing hormone signaling pathway |
|---|
| GO Molecular Function | signal transducer activity |
|---|---|
| adrenocorticotropin receptor activity | |
| hormone activity | |
| corticotropin-releasing hormone binding | |
| adrenocorticotropin-releasing hormone binding | |
| corticotropin-releasing hormone receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| G-protein coupled receptor activity | |
| corticotrophin-releasing factor receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | negative regulation of angiogenesis |
|---|---|
| signal transduction | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| feeding behavior | |
| cell surface receptor linked signaling pathway | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-GsCR |
|---|
| Group | GPCR-GsCR |
|---|---|
| negative regulation of angiogenesis | |
| signal transduction | |
| G-protein signaling, coupled to cAMP nucleotide second messenger | |
| feeding behavior | |
| cell surface receptor linked signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| adrenocorticotropin receptor activity | |
| hormone activity | |
| corticotropin-releasing hormone binding | |
| adrenocorticotropin-releasing hormone binding | |
| corticotropin-releasing hormone receptor activity | |
| receptor activity | |
| transmembrane receptor activity | |
| G-protein coupled receptor activity | |
| corticotrophin-releasing factor receptor activity | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 1395 |
|---|
| Hugo ID | 2358 |
|---|
| Human chromosome position | 7p14.3 |
|---|
| LocusLink ID | 1395 |
|---|---|
| 12922 | |
| 64680 |
| Alias | CRFR2 |
|---|---|
| corticotropin-releasing factor receptor 2 | |
| CRF-R2 | |
| CRFR-2 | |
| CRH-R2 | |
| CRF-R-2 | |
| CRH-R-2 | |
| corticotropin-releasing hormone receptor 2 | |
| CRFR2beta | |
| CRFR2alpha | |
| CRF-RB | |
| CRF 2 receptor | |
| corticotropin-releasing factor 2 | |
| corticotropin releasing factor receptor type 2 beta | |
| Crf2r | |
| CRF2 | |
| CRF-R 2 | |
| CRH-R 2 | |
| corticotrophin releasing hormone receptor 2 | |
| corticotropin-releasing factor receptor subtype 2 | |
| CRH2R | |
| corticotrophin releasing factor receptor 2 | |
| corticotrophin releasing hormone receptor II | |
| corticotrophin-releasing factor 2 | |
| corticotrophin-releasing factor receptor subtype 2 | |
| Corticotropin releasing factor receptor 2 | |
| corticotropin releasing hormone receptor 2 | |
| corticotropin-releasing factor 2 receptor | |
| Corticotropin-releasing hormone receptor II | |
| CRF receptor 2 | |
| CRF2 receptor | |
| CRF-R II | |
| CRH receptor 2 | |
| CRH receptor II | |
| CRH-R II | |
| CRHR2 | |
| OTTHUMP00000024836 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602034 |
|---|
| Mouse chromosome position | 6 28.0 cM |
|---|
| GO ID | 0015056 |
|---|---|
| 0007188 | |
| 0005887 | |
| 0005886 | |
| 0004930 | |
| 0004978 | |
| 0017047 | |
| 0051424 | |
| 0043404 | |
| 0005179 | |
| 0004872 | |
| 0004871 | |
| 0004888 | |
| 0007186 | |
| 0007166 | |
| 0016525 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0007631 |
| Rat chromosome position | 4q24 |
|---|
| Swiss-Prot Accession | Q13324 |
|---|---|
| Q3UQP0 | |
| Q5ERJ2 | |
| Q5GL24 | |
| Q60748 | |
| P47866 | |
| O43461 | |
| Q4QRJ4 | |
| Q99431 |
| PIR ID | A55610 |
|---|
| Unigene ID | Hs.546246 |
|---|---|
| Mm.236081 | |
| Rn.10023 |
| KEGG ID | hsa:1395 |
|---|---|
| mmu:12922 | |
| rno:64680 |
| Swiss-Prot ID | CRFR2_RAT |
|---|---|
| CRFR2_HUMAN | |
| Q3UQP0_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00191135 |
|---|---|
| IPI00231210 | |
| IPI00181589 | |
| IPI00219074 | |
| IPI00297620 | |
| IPI00880470 | |
| IPI00120195 | |
| IPI00553823 | |
| IPI00553563 | |
| IPI00874966 | |
| IPI00781272 |
| Homologene ID | 55612 |
|---|
| RGD ID | 70547 |
|---|
| MGI ID | 894312 |
|---|