Ariadne Genomics Inc. receptor - G protein uncoupling melanocortin system pathway G protein mediated signaling pathway via Galphas family protein kinase A (PKA) signaling pathway HPA axis Crh Gnas receptor internalization CRH neurons stress Crhr2 Crhbp ---- Ucn Crh ---- Crhbp Crhr2 ---- Ucn Ucn ---> cardiovascular functions Ucn2 ---> cardiovascular functions Crh ---- Crhr1 Ucn cAMP --+> protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family --+> cAMP receptor desensitization Arrb2 ---- Crhr1 Arrb1 Arrb2 Arrb1 ---- Crhr1 Adrbk2 Grk6 Adrbk2 ---| Crhr1 Ucn3 Ucn2 Crhbp Crhr2 ---- Ucn2 Grk6 ---| Crhr1 Crhr1 ---- Gnas Crhr1 ---- Ucn Crhr2 ---- Gnas cardiovascular functions gene expression cAMP Ucn3 ---> cardiovascular functions Crhr1 Crhr2 ---- Ucn3 stress --+> CRH neurons Crh --+> melanocortin system pathway