| URN | urn:agi-llid:4311 |
|---|---|
| Connectivity | 385 |
| Name | Mme |
| Description | membrane metallo-endopeptidase |
| Notes | This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq] |
| Pathway | renin-angiotensin system signaling pathway |
|---|---|
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | peptide binding |
|---|---|
| hydrolase activity | |
| metal ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | cell-cell signaling |
|---|---|
| peptide metabolic process | |
| proteolysis |
| Group | cell-cell signaling |
|---|---|
| peptide metabolic process | |
| proteolysis | |
| peptide binding | |
| hydrolase activity | |
| metal ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| metalloendopeptidase activity | |
| membrane | |
| plasma membrane | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 4311 |
|---|
| Hugo ID | 7154 |
|---|
| Human chromosome position | 3q25.1-q25.2 |
|---|
| LocusLink ID | 4311 |
|---|---|
| 17380 | |
| 24590 |
| Alias | NEP |
|---|---|
| CD10 | |
| CALLA | |
| MGC126681 | |
| MGC126707 | |
| DKFZp686O16152 | |
| neprilysin | |
| enkephalinase | |
| atriopeptidase | |
| neutral endopeptidase 24.11 | |
| membrane metallo-endopeptidase variant 1 | |
| membrane metallo-endopeptidase variant 2 | |
| common acute lymphocytic leukemia antigen | |
| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) | |
| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) | |
| C85356 | |
| 6030454K05Rik | |
| common acute lymphoblastic leukemia antigen | |
| MGC93576 | |
| membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase) | |
| EPN | |
| 6030454K05 | |
| common acute lymphoblastic leukaemia antigen | |
| common acute lymphocytic leukaemia antigen | |
| membrane metallo endopeptidase | |
| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA | |
| MME | |
| Neutral endopeptidase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 120520 |
|---|
| Mouse chromosome position | 3 29.6 cM |
|---|
| GO ID | 0046872 |
|---|---|
| 0004222 | |
| 0008237 | |
| 0008233 | |
| 0042277 | |
| 0008270 | |
| 0007267 | |
| 0006518 | |
| 0006508 | |
| 0005887 | |
| 0005624 | |
| 0005886 | |
| 0016787 | |
| 0016021 | |
| 0016020 |
| Rat chromosome position | 2q31 |
|---|
| Swiss-Prot Accession | P08473 |
|---|---|
| Q3KQS6 | |
| Q61391 | |
| Q8BNU9 | |
| P07861 | |
| A8K6U6 | |
| Q3MIX4 | |
| Q6NXX5 | |
| Q8K251 | |
| D3DNJ9 |
| PIR ID | A41387 |
|---|---|
| A29295 |
| Unigene ID | Hs.307734 |
|---|---|
| Mm.296022 | |
| Rn.33598 |
| KEGG ID | hsa:4311 |
|---|---|
| mmu:17380 | |
| rno:24590 |
| EC Number | 3.4.24.11 |
|---|
| Swiss-Prot ID | NEP_HUMAN |
|---|---|
| NEP_MOUSE | |
| NEP_RAT | |
| D3DNJ9_HUMAN | |
| A8K6U6_HUMAN |
| Cell Localization | Cell membrane |
|---|
| IPI ID | IPI00247063 |
|---|---|
| IPI00461861 | |
| IPI00231789 | |
| IPI00654862 | |
| IPI00794750 | |
| IPI00793397 |
| Homologene ID | 5275 |
|---|
| RGD ID | 3098 |
|---|
| MGI ID | 97004 |
|---|