| URN | urn:agi-llid:5973 |
|---|---|
| Connectivity | 11 |
| Name | Renbp |
| Description | renin binding protein |
| Notes | The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq] |
| Pathway | renin-angiotensin system signaling pathway |
|---|---|
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| isomerase activity | |
| enzyme inhibitor activity | |
| purine nucleotide binding | |
| protein homodimerization activity | |
| ATP binding | |
| endopeptidase inhibitor activity | |
| N-acylglucosamine 2-epimerase activity | |
| mannose-6-phosphate isomerase activity |
| GO Cellular Component | cytoplasm |
|---|
| GO Biological Process | mannose metabolic process |
|---|---|
| N-acetylglucosamine metabolic process | |
| regulation of blood pressure |
| Ariadne Ontology | Amino sugars synthesis |
|---|
| Group | Amino sugars synthesis |
|---|---|
| catalytic activity | |
| mannose metabolic process | |
| N-acetylglucosamine metabolic process | |
| regulation of blood pressure | |
| isomerase activity | |
| enzyme inhibitor activity | |
| purine nucleotide binding | |
| protein homodimerization activity | |
| ATP binding | |
| endopeptidase inhibitor activity | |
| N-acylglucosamine 2-epimerase activity | |
| mannose-6-phosphate isomerase activity | |
| cytoplasm |
| MedScan ID | 5973 |
|---|
| Hugo ID | 9959 |
|---|
| Human chromosome position | Xq28 |
|---|
| LocusLink ID | 5973 |
|---|---|
| 19703 | |
| 81759 |
| Alias | RBP |
|---|---|
| RNBP | |
| N-acylglucosamine 2-epimerase | |
| AGE | |
| GlcNAc 2-epimerase | |
| N-acetyl-D-glucosamine 2-epimerase | |
| RP23-252M19.4 | |
| OTTMUSP00000019265 | |
| OTTMUSP00000019679 | |
| OTTMUSP00000026295 | |
| renin-binding protein | |
| acylglucosamine 2-epimerase | |
| acylglucosamine 2-epimerases | |
| N-acetylglucosamine 2-epimerase | |
| N-acetylglucosamine 2-epimerases | |
| OTTHUMP00000196204 | |
| RENBP | |
| renin binding protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 312420 |
|---|
| Mouse chromosome position | X 29.53 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0050121 | |
| 0004866 | |
| 0016853 | |
| 0004476 | |
| 0042803 | |
| 0017076 | |
| 0006044 | |
| 0006013 | |
| 0008217 | |
| 0003824 | |
| 0004857 | |
| 0005737 |
| Rat chromosome position | Xq37 |
|---|
| Swiss-Prot Accession | B4DNZ3 |
|---|---|
| P51606 | |
| Q3TIZ6 | |
| Q3UJ23 | |
| P82343 | |
| P51607 | |
| Q96BI6 |
| PIR ID | JX0187 |
|---|---|
| JX0188 |
| Unigene ID | Hs.158331 |
|---|---|
| Mm.236969 | |
| Rn.11116 |
| KEGG ID | hsa:5973 |
|---|---|
| mmu:19703 | |
| rno:81759 |
| EC Number | 5.1.3.8 |
|---|
| Swiss-Prot ID | RENBP_RAT |
|---|---|
| RENBP_HUMAN | |
| RENBP_MOUSE | |
| B4DNZ3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00204162 |
|---|---|
| IPI00937516 | |
| IPI00879688 | |
| IPI00796170 | |
| IPI00644691 | |
| IPI00646161 | |
| IPI00293648 | |
| IPI00878176 | |
| IPI00894539 | |
| IPI00124826 | |
| IPI00776203 | |
| IPI00880510 |
| Homologene ID | 2184 |
|---|
| RGD ID | 621688 |
|---|
| MGI ID | 105940 |
|---|