| URN | urn:agi-llid:4012 |
|---|---|
| Connectivity | 95 |
| Name | Lnpep |
| Description | leucyl/cystinyl aminopeptidase |
| Notes | This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Pathway | insulin responsive facilitative sugar transporter mediated glucose transport pathway |
|---|---|
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| renin-angiotensin system signaling pathway | |
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptide hormone binding | |
| angiotensin receptor activity | |
| metal ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| aminopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| endomembrane system | |
| cell surface | |
| membrane | |
| intracellular | |
| intracellular organelle | |
| vesicle | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| insulin-responsive compartment | |
| membrane fraction | |
| microsome | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | female pregnancy |
|---|---|
| cell-cell signaling | |
| regulation of long-term neuronal synaptic plasticity | |
| natriuresis | |
| peptide catabolic process | |
| neuropeptide catabolic process | |
| response to hormone stimulus | |
| protein catabolic process | |
| proteolysis |
| Group | extracellular region |
|---|---|
| female pregnancy | |
| cell-cell signaling | |
| regulation of long-term neuronal synaptic plasticity | |
| natriuresis | |
| peptide catabolic process | |
| neuropeptide catabolic process | |
| response to hormone stimulus | |
| protein catabolic process | |
| proteolysis | |
| hydrolase activity | |
| peptide hormone binding | |
| angiotensin receptor activity | |
| metal ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| aminopeptidase activity | |
| endomembrane system | |
| cell surface | |
| membrane | |
| intracellular | |
| intracellular organelle | |
| vesicle | |
| plasma membrane | |
| neuronal cell body | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| insulin-responsive compartment | |
| membrane fraction | |
| microsome | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 4012 |
|---|
| Hugo ID | 6656 |
|---|
| Human chromosome position | 5q15 |
|---|
| LocusLink ID | 4012 |
|---|---|
| 240028 | |
| 171105 |
| Alias | CAP |
|---|---|
| IRAP | |
| PLAP | |
| P-LAP | |
| leucyl-cystinyl aminopeptidase | |
| otase | |
| oxytocinase | |
| vasopressinase | |
| AT (4) receptor | |
| angiotensin IV receptor | |
| cystinyl aminopeptidase | |
| insulin-regulated aminopeptidase | |
| placental leucine aminopeptidase | |
| insulin-responsive aminopeptidase | |
| insulin-regulated membrane aminopeptidase | |
| gp160 | |
| vp165 | |
| 2010309L07Rik | |
| 4732490P18Rik | |
| aminopeptidase Vp165 | |
| vesicle protein of 165 kDa | |
| insulin-regulated membrane aminopeptidase IRAP | |
| 2010309L07 | |
| 4732490P18 | |
| cystine aminopeptidase | |
| cystine aminopeptidases | |
| cystinyl aminopeptidases | |
| cystyl-aminopeptidase | |
| cystyl-aminopeptidases | |
| FLJ39485 | |
| L-cystine aminopeptidase | |
| L-cystine aminopeptidases | |
| leucyl/cystinyl aminopeptidase | |
| LNPEP | |
| OTTHUMP00000196800 | |
| oxytocin peptidase | |
| oxytocin peptidases | |
| placental leucil aminopeptidase | |
| vasopressinases | |
| RIKEN cDNA 4732490P18 gene | |
| RIKEN cDNA 2010309L07 gene | |
| vasopresssinase | |
| vasopresssinases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 151300 |
|---|
| Mouse chromosome position | 17 |
|---|---|
| 17 A3.2 |
| GO ID | 0004177 |
|---|---|
| 0046872 | |
| 0008237 | |
| 0008233 | |
| 0008270 | |
| 0007267 | |
| 0007565 | |
| 0030163 | |
| 0006508 | |
| 0005576 | |
| 0005887 | |
| 0005622 | |
| 0005624 | |
| 0005792 | |
| 0048471 | |
| 0005886 | |
| 0001595 | |
| 0016787 | |
| 0017046 | |
| 0030147 | |
| 0010813 | |
| 0043171 | |
| 0048169 | |
| 0009725 | |
| 0009986 | |
| 0005737 | |
| 0032593 | |
| 0016021 | |
| 0043229 | |
| 0016020 | |
| 0043025 | |
| 0031982 | |
| 0012505 | |
| 0005515 | |
| 0004179 | |
| 0008152 |
| Rat chromosome position | 1q12 |
|---|
| Swiss-Prot Accession | Q9UIQ6 |
|---|---|
| Q8C129 | |
| Q3TTA8 | |
| Q6NY09 | |
| Q8BZ14 | |
| P97629 | |
| Q8R438 | |
| Q11009 | |
| O00769 | |
| Q15145 | |
| Q59H76 | |
| Q9TNQ2 | |
| Q9TNQ3 | |
| Q9UIQ7 |
| PIR ID | I55441 |
|---|---|
| A59383 | |
| A59384 |
| Unigene ID | Hs.527199 |
|---|---|
| Hs.656905 | |
| Mm.328807 | |
| Mm.393452 | |
| Rn.10614 |
| KEGG ID | hsa:4012 |
|---|---|
| mmu:240028 | |
| rno:171105 |
| EC Number | 3.4.11.3 |
|---|
| Swiss-Prot ID | LCAP_MOUSE |
|---|---|
| LCAP_RAT | |
| LCAP_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Endomembrane system | |
| Secreted |
| IPI ID | IPI00223987 |
|---|---|
| IPI00206434 | |
| IPI00221240 | |
| IPI00221241 | |
| IPI00307017 | |
| IPI00871815 | |
| IPI00167478 | |
| IPI00779663 |
| Homologene ID | 21148 |
|---|
| RGD ID | 621752 |
|---|
| MGI ID | 2387123 |
|---|