| URN | urn:agi-llid:4142 |
|---|---|
| Connectivity | 31 |
| Name | Mas1 |
| Description | MAS1 oncogene |
| Notes | The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. [provided by RefSeq] |
| Pathway | renin-angiotensin system signaling pathway |
|---|---|
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| peptide binding | |
| peptide hormone binding | |
| angiotensin receptor activity | |
| angiotensin type II receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| anatomical structure morphogenesis | |
| response to activity | |
| hippocampus development | |
| male gonad development | |
| spermatogenesis | |
| signal transduction | |
| protein kinase C signaling cascade | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of inositol phosphate biosynthetic process | |
| positive regulation of DNA replication | |
| cellular response to peptide hormone stimulus | |
| response to drug | |
| response to peptide hormone stimulus | |
| response to gonadotropin stimulus | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | GPCR-GqCR |
|---|---|
| Oncogenes |
| Group | GPCR-GqCR |
|---|---|
| Oncogenes | |
| cell proliferation | |
| positive regulation of cell proliferation | |
| anatomical structure morphogenesis | |
| response to activity | |
| hippocampus development | |
| male gonad development | |
| spermatogenesis | |
| signal transduction | |
| protein kinase C signaling cascade | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of inositol phosphate biosynthetic process | |
| positive regulation of DNA replication | |
| cellular response to peptide hormone stimulus | |
| response to drug | |
| response to peptide hormone stimulus | |
| response to gonadotropin stimulus | |
| G-protein coupled receptor protein signaling pathway | |
| signal transducer activity | |
| peptide binding | |
| peptide hormone binding | |
| angiotensin receptor activity | |
| angiotensin type II receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| cell surface | |
| membrane | |
| plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 4142 |
|---|
| Hugo ID | 6899 |
|---|
| Human chromosome position | 6q25.3-q26 |
|---|
| LocusLink ID | 4142 |
|---|---|
| 17171 | |
| 25153 |
| Alias | MAS |
|---|---|
| MGC119966 | |
| proto-oncogene Mas | |
| Mas-1 | |
| MAS proto-oncogene | |
| angiotensin-(1-7) receptor | |
| c-mas | |
| MAS I | |
| MAS1 | |
| MAS1 oncogene | |
| OTTHUMP00000017535 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165180 |
|---|
| Mouse chromosome position | 17 7.45 cM |
|---|
| GO ID | 0004930 |
|---|---|
| 0001595 | |
| 0004945 | |
| 0042277 | |
| 0017046 | |
| 0004872 | |
| 0007186 | |
| 0009653 | |
| 0008283 | |
| 0071375 | |
| 0021766 | |
| 0008584 | |
| 0001933 | |
| 0045740 | |
| 0008284 | |
| 0060732 | |
| 0070528 | |
| 0014823 | |
| 0042493 | |
| 0034698 | |
| 0007283 | |
| 0009986 | |
| 0005887 | |
| 0005886 | |
| 0004871 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0043434 |
| Rat chromosome position | 1q11-q12 |
|---|
| Swiss-Prot Accession | P04201 |
|---|---|
| P30554 | |
| Q0VB49 | |
| Q9D5Q2 | |
| P12526 | |
| Q2TBC9 | |
| Q6FG47 |
| PIR ID | A31816 |
|---|---|
| A01375 |
| Unigene ID | Hs.99900 |
|---|---|
| Mm.425994 | |
| Rn.21943 |
| KEGG ID | hsa:4142 |
|---|---|
| mmu:17171 | |
| rno:25153 |
| Swiss-Prot ID | MAS_RAT |
|---|---|
| MAS_HUMAN | |
| Q0VB49_MOUSE | |
| MAS_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00198560 |
|---|---|
| IPI00022860 | |
| IPI00131264 |
| Homologene ID | 1782 |
|---|
| RGD ID | 3049 |
|---|
| MGI ID | 96918 |
|---|