| URN | urn:agi-llid:290 |
|---|---|
| Connectivity | 204 |
| Name | Anpep |
| Description | alanyl (membrane) aminopeptidase |
| Notes | Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq] |
| Pathway | renin-angiotensin system signaling pathway |
|---|---|
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | peptide binding |
|---|---|
| hydrolase activity | |
| metal ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| aminopeptidase activity | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| ER-Golgi intermediate compartment | |
| cytosol | |
| integral to membrane | |
| integral to plasma membrane | |
| vesicle membrane | |
| vesicle lumen |
| GO Biological Process | multicellular organismal development |
|---|---|
| interspecies interaction between organisms | |
| cell differentiation | |
| angiogenesis | |
| cellular aromatic compound metabolic process | |
| proteolysis |
| Group | multicellular organismal development |
|---|---|
| interspecies interaction between organisms | |
| cell differentiation | |
| angiogenesis | |
| cellular aromatic compound metabolic process | |
| proteolysis | |
| peptide binding | |
| hydrolase activity | |
| metal ion binding | |
| zinc ion binding | |
| peptidase activity | |
| metallopeptidase activity | |
| aminopeptidase activity | |
| receptor activity | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| ER-Golgi intermediate compartment | |
| cytosol | |
| integral to membrane | |
| integral to plasma membrane | |
| vesicle membrane | |
| vesicle lumen |
| MedScan ID | 290 |
|---|
| Hugo ID | 500 |
|---|
| Human chromosome position | 15q25-q26 |
|---|
| LocusLink ID | 290 |
|---|---|
| 16790 | |
| 81641 |
| Alias | APN |
|---|---|
| CD13 | |
| LAP1 | |
| P150 | |
| PEPN | |
| GP150 | |
| aminopeptidase N | |
| AP-M | |
| AP-N | |
| hAPN | |
| aminopeptidase M | |
| alanyl aminopeptidase | |
| microsomal aminopeptidase | |
| myeloid plasma membrane glycoprotein CD13 | |
| Lap-1 | |
| mAPN | |
| OTTMUSP00000025718 | |
| aminopeptidase N/CD13 | |
| membrane protein p161 | |
| leucine arylaminopeptidase 1, intestinal | |
| Apm | |
| KZP | |
| rAPN | |
| kidney Zn peptidase | |
| kidney aminopeptidase M | |
| leucine arylaminopeptidase 1 | |
| membrane alanine aminopeptidase | |
| cluster of differentiation antigen 13 (CD13) | |
| 4833403I15 | |
| 4833403I15Rik | |
| alanyl (membrane) aminopeptidase | |
| Anpep | |
| APN/CD13 | |
| cluster of differentiation antigen 13 | |
| Leucine arylaminopeptidase I | |
| membrane alanyl aminopeptidase | |
| OTTHUMP00000194690 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 151530 |
|---|
| Mouse chromosome position | 7 |
|---|
| GO ID | 0004177 |
|---|---|
| 0046872 | |
| 0008237 | |
| 0008233 | |
| 0042277 | |
| 0004872 | |
| 0008270 | |
| 0001525 | |
| 0030154 | |
| 0006725 | |
| 0044419 | |
| 0007275 | |
| 0006508 | |
| 0005793 | |
| 0005737 | |
| 0005829 | |
| 0005887 | |
| 0005886 | |
| 0005625 | |
| 0031983 | |
| 0012506 | |
| 0016787 | |
| 0016021 | |
| 0016020 |
| Rat chromosome position | 1q31 |
|---|
| Swiss-Prot Accession | P15144 |
|---|---|
| Q59E93 | |
| Q71E46 | |
| Q8IVL7 | |
| P97449 | |
| Q3TB69 | |
| Q3UP74 | |
| P15684 | |
| Q9QX17 | |
| Q9QX18 | |
| Q91YH8 | |
| Q99K63 | |
| Q9JHP4 | |
| Q16728 | |
| Q6GT90 | |
| Q8IUK3 | |
| Q8IVH3 | |
| Q9UCE0 |
| PIR ID | A32852 |
|---|---|
| A30325 |
| Unigene ID | Hs.1239 |
|---|---|
| Mm.4487 | |
| Rn.11132 | |
| Rn.179371 |
| KEGG ID | hsa:290 |
|---|---|
| mmu:16790 | |
| rno:81641 |
| EC Number | 3.4.11.2 |
|---|
| Swiss-Prot ID | AMPN_MOUSE |
|---|---|
| AMPN_RAT | |
| AMPN_HUMAN | |
| Q3UP74_MOUSE | |
| Q3TB69_MOUSE | |
| Q59E93_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Cytoplasm | |
| cytosol |
| IPI ID | IPI00319509 |
|---|---|
| IPI00230862 | |
| IPI00221224 |
| Homologene ID | 68163 |
|---|
| RGD ID | 2991 |
|---|
| MGI ID | 96749 |
|---|