| URN | urn:agi-llid:1215 |
|---|---|
| Connectivity | 296 |
| Name | Cma1 |
| Description | chymase 1, mast cell |
| Notes | This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq] |
| Pathway | renin-angiotensin system signaling pathway |
|---|---|
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| peptide binding | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| intracellular | |
| extracellular matrix |
| GO Biological Process | regulation of inflammatory response |
|---|---|
| proteolysis | |
| interleukin-1 beta biosynthetic process |
| Ariadne Ontology | ECM degradation |
|---|
| Group | ECM degradation |
|---|---|
| extracellular region | |
| catalytic activity | |
| regulation of inflammatory response | |
| proteolysis | |
| interleukin-1 beta biosynthetic process | |
| peptide binding | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| intracellular | |
| extracellular matrix |
| MedScan ID | 1215 |
|---|
| Hugo ID | 2097 |
|---|
| Human chromosome position | 14q11.2 |
|---|
| LocusLink ID | 1215 |
|---|---|
| 17228 | |
| 25627 |
| Alias | CYH |
|---|---|
| MCT1 | |
| chymase | |
| MGC119890 | |
| MGC119891 | |
| alpha-chymase | |
| chymase, heart | |
| chymase, mast cell | |
| mast cell protease I | |
| chymase 1 preproprotein transcript E | |
| chymase 1 preproprotein transcript I | |
| Mcp-5 | |
| Mcpt5 | |
| MMCP-5 | |
| mast cell chymase 1 | |
| mast cell protease 5 | |
| MCP3P | |
| rMCP-3 | |
| rMCP-5 | |
| rMCP-III | |
| mast cell protease 3 | |
| mast cell protease III | |
| Mcpt3 | |
| CYM | |
| chymase 1 | |
| chymase 1, mast cell | |
| chymase I | |
| Chymase precursors | |
| CMA I | |
| CMA1 | |
| mast cell protease 1 | |
| mast cell protease 2 | |
| mast cell protease 4 | |
| mast cell protease IV | |
| mast cell protease V | |
| mast cell protease-like | |
| mast cell serine proteinase, chymase | |
| mast cell serine proteinase, chymases | |
| Mcp V | |
| Mcpt I | |
| Mcpt1 | |
| Mcpt2 | |
| Mcpt4 | |
| Mcptl | |
| MMCP II | |
| MMCP IIs | |
| MMCP IV | |
| MMCP IVs | |
| MMCP V | |
| MMCP-2 | |
| MMCP-4 | |
| MMCP-4A | |
| MMCP-4B | |
| MMCP-L | |
| myonase | |
| myonases | |
| skeletal muscle (SK) protease | |
| skeletal muscle (SK) proteases | |
| skeletal muscle protease | |
| skeletal muscle proteases | |
| skin chymotryptic proteinase | |
| skin chymotryptic proteinases | |
| vascular chymase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 118938 |
|---|
| Mouse chromosome position | 14 20.0 cM |
|---|
| GO ID | 0008233 |
|---|---|
| 0004252 | |
| 0008236 | |
| 0050720 | |
| 0006508 | |
| 0050727 | |
| 0031012 | |
| 0005576 | |
| 0005622 | |
| 0003824 | |
| 0016787 | |
| 0042277 |
| Rat chromosome position | 15p13 |
|---|
| Swiss-Prot Accession | P23946 |
|---|---|
| Q3SY37 | |
| Q4FEB3 | |
| Q4FEB5 | |
| A4QPC5 | |
| P21844 | |
| P50339 | |
| Q9R2C8 | |
| B5BUM8 | |
| Q16018 | |
| Q3SY36 | |
| Q9UDH5 | |
| Q9R1F0 |
| PIR ID | S59135 |
|---|---|
| A40967 | |
| S23504 | |
| S26043 |
| Unigene ID | Hs.135626 |
|---|---|
| Mm.1252 | |
| Rn.10182 |
| KEGG ID | hsa:1215 |
|---|---|
| mmu:17228 | |
| rno:25627 |
| EC Number | 3.4.21.39 |
|---|
| Swiss-Prot ID | CMA1_RAT |
|---|---|
| CMA1_HUMAN | |
| CMA1_MOUSE | |
| A4QPC5_MOUSE | |
| B5BUM8_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Cytoplasmic granule | |
| Extracellular |
| IPI ID | IPI00197397 |
|---|---|
| IPI00013937 | |
| IPI00230426 | |
| IPI00004922 |
| Homologene ID | 55606 |
|---|
| RGD ID | 2365 |
|---|
| MGI ID | 96941 |
|---|