| URN | urn:agi-llid:3482 |
|---|---|
| Connectivity | 238 |
| Name | Igf2r |
| Description | insulin-like growth factor 2 receptor |
| Notes | The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq] |
| Pathway | renin-angiotensin system signaling pathway |
|---|---|
| Copy oenin-angiotensin cascade pathway | |
| renin-angiotensin cascade pathway |
| GO Molecular Function | transporter activity |
|---|---|
| phosphoprotein binding | |
| glycoprotein binding | |
| G-protein alpha-subunit binding | |
| enzyme binding | |
| insulin-like growth factor binding | |
| insulin-like growth factor II binding | |
| retinoic acid binding | |
| mannose binding | |
| insulin-like growth factor receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity |
| GO Cellular Component | cell surface |
|---|---|
| membrane | |
| extracellular space | |
| cytoplasm | |
| endosome | |
| perinuclear region of cytoplasm | |
| Golgi apparatus | |
| trans-Golgi network | |
| trans-Golgi network transport vesicle | |
| lysosomal membrane | |
| lysosome | |
| endocytic vesicle | |
| nuclear envelope lumen | |
| nucleus | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | post-embryonic development |
|---|---|
| transport | |
| liver development | |
| organ regeneration | |
| spermatogenesis | |
| signal transduction | |
| positive regulation of apoptosis | |
| regulation of apoptosis | |
| receptor-mediated endocytosis | |
| response to retinoic acid | |
| protein transport | |
| G-protein coupled receptor protein signaling pathway |
| Ariadne Ontology | Scavenger receptor |
|---|
| Group | Scavenger receptor |
|---|---|
| transporter activity | |
| post-embryonic development | |
| transport | |
| liver development | |
| organ regeneration | |
| spermatogenesis | |
| signal transduction | |
| positive regulation of apoptosis | |
| regulation of apoptosis | |
| receptor-mediated endocytosis | |
| response to retinoic acid | |
| protein transport | |
| G-protein coupled receptor protein signaling pathway | |
| phosphoprotein binding | |
| glycoprotein binding | |
| G-protein alpha-subunit binding | |
| enzyme binding | |
| insulin-like growth factor binding | |
| insulin-like growth factor II binding | |
| retinoic acid binding | |
| mannose binding | |
| insulin-like growth factor receptor activity | |
| receptor activity | |
| G-protein coupled receptor activity | |
| cell surface | |
| membrane | |
| extracellular space | |
| cytoplasm | |
| endosome | |
| perinuclear region of cytoplasm | |
| Golgi apparatus | |
| trans-Golgi network | |
| trans-Golgi network transport vesicle | |
| lysosomal membrane | |
| lysosome | |
| endocytic vesicle | |
| nuclear envelope lumen | |
| nucleus | |
| membrane fraction | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 3482 |
|---|
| Hugo ID | 5467 |
|---|
| Human chromosome position | 6q26 |
|---|
| LocusLink ID | 3482 |
|---|---|
| 16004 | |
| 25151 |
| Alias | MPR1 |
|---|---|
| MPRI | |
| CD222 | |
| CIMPR | |
| M6P-R | |
| cation-independent mannose-6-phosphate receptor | |
| M6PR | |
| CI-MPR | |
| MPR 300 | |
| M6P/IGF2R | |
| IGF-II receptor | |
| M6P/IGF2 receptor | |
| CI Man-6-P receptor | |
| 300 kDa mannose 6-phosphate receptor | |
| insulin-like growth factor II receptor | |
| cation-independent mannose-6 phosphate receptor | |
| Mpr300 | |
| AI661837 | |
| IGF-II/CI-MPR | |
| cation-independent MPR | |
| cation-independent mannose 6-phosphate receptor | |
| mannose-6-phosphate receptor, cation independent | |
| 300 KDA mannose 6-phosphate receptors | |
| cation-independent mannose-6 phosphate receptors | |
| CI MAN-6-P receptors | |
| IGF2 receptor | |
| Igf2 receptors | |
| Igf2r | |
| insulin-like growth factor 2 receptor | |
| insulin-like growth factor 2 receptors | |
| Insulin-like growth factor II receptors | |
| insulin-like growth factor-2 receptor (mannose-6-phosphate receptor, cation-independent) | |
| mannose-6-phosphate receptor | |
| mannose-6-phosphate/insulin-like growth factor 2 receptor | |
| mannose-6-phosphate/insulin-like growth factor II receptor | |
| MPRI_HUMAN | |
| OTTHUMP00000017536 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147280 |
|---|
| Mouse chromosome position | 17 7.35 cM |
|---|
| GO ID | 0001965 |
|---|---|
| 0004930 | |
| 0019899 | |
| 0001948 | |
| 0031995 | |
| 0005010 | |
| 0005537 | |
| 0051219 | |
| 0004872 | |
| 0001972 | |
| 0005215 | |
| 0001889 | |
| 0031100 | |
| 0043065 | |
| 0009791 | |
| 0006898 | |
| 0032526 | |
| 0007165 | |
| 0007283 | |
| 0009986 | |
| 0005737 | |
| 0030139 | |
| 0005768 | |
| 0005615 | |
| 0005887 | |
| 0005765 | |
| 0016020 | |
| 0005624 | |
| 0005641 | |
| 0005634 | |
| 0048471 | |
| 0005802 | |
| 0030140 | |
| 0005520 | |
| 0007186 | |
| 0042981 | |
| 0006810 | |
| 0016021 | |
| 0005764 | |
| 0015031 | |
| 0005794 |
| Rat chromosome position | 1q11 |
|---|
| Swiss-Prot Accession | P11717 |
|---|---|
| Q59EZ3 | |
| Q07113 | |
| Q8C6V9 | |
| Q4L138 | |
| Q7TMR1 | |
| Q80VF2 | |
| Q8C2F9 | |
| Q8K0J1 | |
| Q63002 | |
| Q61822 | |
| Q6LED1 | |
| Q7Z7G9 | |
| Q96PT5 | |
| Q63757 |
| PIR ID | A49617 |
|---|---|
| I48922 | |
| A28372 | |
| A40103 |
| Unigene ID | Hs.487062 |
|---|---|
| Mm.26553 | |
| Rn.270 |
| KEGG ID | hsa:3482 |
|---|---|
| mmu:16004 | |
| rno:25151 |
| Swiss-Prot ID | MPRI_MOUSE |
|---|---|
| MPRI_HUMAN | |
| Q8C6V9_MOUSE | |
| Q63002_RAT |
| Cell Localization | Lysosome membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00308971 |
|---|---|
| IPI00289819 | |
| IPI00332022 | |
| IPI00903213 |
| Homologene ID | 676 |
|---|
| RGD ID | 2871 |
|---|
| MGI ID | 96435 |
|---|