Ariadne Genomics Inc. Ren Agtr2 Agtr1a Agtr1b Mas1 Lnpep angiotensin III signaling via AT2 receptor angiotensin III signaling pathway angiotensin (1-7) signaling pathway angiotensin IV signaling pathway angiotensin II signaling pathway angiotensin II signaling via AT2 receptor angiotensin II signaling via AT1 receptor Enpep Anpep Mme Ace2 Ace renin receptor mediated intracellular signaling angiotensin IV signaling pathway ---> cognition AgtIII ---- Agtr1a Renbp ---| Ren Renbp Agt ---> AgtI AgtIII ---- Agtr2 cognition AgtII ---- Agtr1b AgtIV ---- Lnpep AgtII ---- Agtr2 AgtI ---> AgtII Igf2r ---- Ren angiotensin III signaling via AT1 receptor ---> cell proliferation vasodilation AgtII ---- Agtr1a angiotensin III signaling via AT2 receptor ---> vasodilation angiotensin II signaling via AT2 receptor ---> vasodilation Atp6ap2 ---- Ren Cma1 Atp6ap2 ---> renin receptor mediated intracellular signaling Igf2r cell proliferation vasoconstriction angiotensin II signaling via AT1 receptor ---> cell proliferation Igf2r ---> complex internalization complex internalization AgtII ---> AgtIII Agt AgtI ---> Agt(1-7) AgtIII ---> AgtIV AgtII ---> Agt(1-7) AgtIII ---- Agtr1b AgtI Agt(1-7) AgtIII AgtIV AgtII Ren ---- Renbp Ren ---> renin receptor mediated intracellular signaling angiotensin III signaling via AT1 receptor angiotensin III signaling via AT1 receptor ---> vasoconstriction angiotensin II signaling via AT1 receptor ---> vasoconstriction angiotensin (1-7) signaling pathway ---> vasodilation Atp6ap2 Agt(1-7) ---- Mas1