| URN | urn:agi-ProtModification:inout-urn:agi-llid:4243:out-urn:agi-llid:7046::positive:phosphorylation |
|---|---|
| References | 91 |
| Connectivity | 2 |
| Effect | positive |
| Mechanism | phosphorylation |
| Original # of References | 81 |
| TextRef | info:pmid/7988555#abs:9 |
|---|---|
| PubYear | 1994 |
| MedlineTA | EMBO J |
| MedLine Reference | 7988555:8 |
| Sentence | Once formed, this complex is sufficient for T beta R-I phosphorylation by T beta R-II. |
| TextRef | info:pmid/7862150#abs:3 |
|---|---|
| PubYear | 1995 |
| MedlineTA | Mol Cell Biol |
| MedLine Reference | 7862150:2 |
| Sentence | T beta R-I phosphorylation by T beta R-II is shown here to be essential for signaling. |
| TextRef | info:pmid/9233797#abs:1 |
|---|---|
| PubYear | 1997 |
| MedlineTA | EMBO J |
| MedLine Reference | 9233797:0 |
| Sentence | Transforming growth factor-beta (TGFbeta) signaling requires phosphorylation of the type I receptor TbetaR-I by TbetaR-II. |
| TextRef | info:pmid/8873772#abs:2 |
|---|---|
| PubYear | 1996 |
| MedlineTA | Dev Biol |
| MedLine Reference | 8873772:1 |
| Sentence | In this signaling complex, ligand binding TGF-betaRII phosphorylates and thereby activates the TGF-betaRI to signal downstream pathways. |
| TextRef | info:pmid/10026191#abs:3 |
|---|---|
| MedLine Reference | 10026191:2 |
| Sentence | Velocity centrifugation of endogenous receptors suggests that ligand-bound TbetaRI and TbetaRII form a heteromeric complex that is most likely a heterotetramer. |
| TextRef | info:pmid/9311995#abs:4 |
|---|---|
| PubYear | 1997 |
| MedlineTA | EMBO J |
| MedLine Reference | 9311995:3 |
| Sentence | Here we show that Smad2 and Smad3 interacted with the kinase-deficient TGF-beta type I receptor -I after it was phosphorylated by TbetaR-II kinase. |
| TextMods | 96: '(TbetaR)' -> '' |
| TextRef | info:pmid/7878020#abs:5 |
|---|---|
| PubYear | 1995 |
| MedlineTA | Proc Natl Acad Sci U S A |
| MedLine Reference | 7878020:4 |
| Sentence | Both wild-type TGF-beta RI and a kinase-deficient mutant thereof are transphosphorylated by the coexpressed TGF-beta RII kinase in a ligand-independent fashion in these cells. |
| TextRef | info:pmid/9856985#abs:3 |
|---|---|
| MedLine Reference | 9856985:2 |
| Sentence | Several studies have shown that TbetaR-II acts as a primary receptor, binding TGF-beta and phosphorylating TbetaR-I, whose kinase activity then propagates the signals. |
| TextRef | info:pmid/7774578#abs:2 |
|---|---|
| PubYear | 1995 |
| MedlineTA | EMBO J |
| MedLine Reference | 7774578:1 |
| Sentence | T beta R-I is phosphorylated by T beta R-II in the GS domain, a 30 amino acid region preceding the kinase domain and conserved in type I receptors for other TGF-beta-related factors. |
| TextRef | info:pmid/9662508#abs:2 |
|---|---|
| PubYear | 1998 |
| MedlineTA | Chem Biol |
| MedLine Reference | 9662508:1 |
| Sentence | In the signaling pathway, TGF-beta binds to the extracellular domain of TGF-betaRII, which can then transphosphorylate TGF-betaRI in its glycine/serine -rich box. |
| TextMods | 152: '(GS)' -> '' |
| TextRef | info:pmid/9545258#abs:1 |
|---|---|
| PubYear | 1998 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 9545258:0 |
| Sentence | Transforming growth factor beta (TGFbeta) signal transduction is mediated by two receptor Ser/Thr kinases acting in series, type II TGFbeta receptor (TbetaR-II) phosphorylating type I TGFbeta receptor (TbetaR-I). |
| TextRef | info:pmid/8530343#abs:3 |
|---|---|
| PubYear | 1995 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 8530343:2 |
| Sentence | Recent studies have shown that T beta R-II is a constitutively active kinase and phosphorylates T beta R-I upon ligand binding, suggesting that T beta R-I is the effector subunit of the receptor complex, which transduces signals to intracellular targets. |
| TextRef | info:pmid/16166229#body:75 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Endocrinology |
| MedLine Reference | 16166229:1074 |
| Sentence | Upon ligand binding, TβRII phosphorylates TβRI (13). |
| Organ | Bone and Bones |
| TextRef | info:pmid/14580334#body:306 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Mol Cell |
| MedLine Reference | 14580334:1305 |
| Sentence | ALK5 is phosphorylated and activated by TβRII kinase. |
| CellType | Endothelial Cells |
| TextRef | info:pmid/16707625#body:62 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Mol Pharmacol |
| MedLine Reference | 16707625:1061 |
| Sentence | Upon ligand binding, TGFβRII transphosphorylates TGFβRI. |
| Organ | Lung |
| TextRef | info:pmid/11406536#body:42 |
|---|---|
| PubYear | 2001 |
| MedlineTA | Cancer Res |
| MedLine Reference | 11406536:1041 |
| Sentence | As a consequence, the TβR-II kinase phosphorylates and activates TβR-I (5) . |
| TextRef | info:pmid/9660945#body:88 |
|---|---|
| PubYear | 1998 |
| MedlineTA | Mol Cell |
| MedLine Reference | 9660945:1087 |
| Sentence | TGFβRII binds TGFβ and subsequently phosphorylates TGFβRI ( [35 and 3]). |
| TextRef | info:pmid/12191474#body:101 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Mol Cell |
| MedLine Reference | 12191474:1100 |
| Sentence | TβRII phosphorylates and activates ALK5 which in turn phosphorylates downstream substrates. |
| TextRef | info:pmid/9670020#body:263 |
|---|---|
| PubYear | 1998 |
| MedlineTA | EMBO J |
| MedLine Reference | 9670020:1262 |
| Sentence | TGF-β type II receptor (TβR-II) transphosphorylates the type I receptor (TβR-I) upon ligand binding. |
| TextRef | info:pmid/15056732#body:71 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Mol Endocrinol |
| MedLine Reference | 15056732:1070 |
| Sentence | TβRII phosphorylates TβRI, which activates TβRI kinase and initiates downstream signaling (14). |
| TextRef | info:pmid/19056678#body:45 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Mol Biol Cell |
| MedLine Reference | 19056678:1044 |
| Sentence | Ligand binding promotes the formation of receptor complex where TβRII phosphorylates TβRI. |
| Tissue | Epithelium |
| TextRef | info:pmid/9155023#body:237 |
|---|---|
| PubYear | 1997 |
| MedlineTA | EMBO J |
| MedLine Reference | 9155023:1236 |
| Sentence | Phosphorylation of Ser213 is required for the kinase activity of TβRII and its ability to phosphorylate TβRI. |
| TextRef | info:pmid/17999987#body:81 |
|---|---|
| PubYear | 2008 |
| MedlineTA | Carcinogenesis |
| MedLine Reference | 17999987:1080 |
| Sentence | Once ligand bound, TβRII recruits and phosphorylates TβRI to activate its kinase activity. |
| CellType | Epithelial Cells |
| Organ | Mesenchyme |
| TextRef | info:pmid/12019154#body:66 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Cancer Res |
| MedLine Reference | 12019154:1065 |
| Sentence | For classic signal transduction, active TGF-β isoforms bind to TβRII, which subsequently phosphorylates TβRI. |
| TextRef | info:pmid/16258068#body:189 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Proc Natl Acad Sci U S A |
| MedLine Reference | 16258068:1188 |
| Sentence | These findings indicate that EN suppresses the ability of the TβRII kinase to transphosphorylate and hence activate TβRI. |
| TextRef | info:pmid/16698802#body:167 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Carcinogenesis |
| MedLine Reference | 16698802:1166 |
| Sentence | Upon TGFβ binding to the TGFβ receptor complex, the TβRII phosphorylates TβRI and Par6. |
| CellType | Epithelial Cells |
| TextRef | info:pmid/11102446#body:34 |
|---|---|
| PubYear | 2001 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 11102446:1033 |
| Sentence | The activation of this membrane complex occurs via the ligand-dependent phosphorylation of TβR-I by TβR-II (5, 6). |
| Organ | Bone and Bones |
| TextRef | info:pmid/9950213#body:45 |
|---|---|
| PubYear | 1999 |
| MedlineTA | Cell Growth Differ |
| MedLine Reference | 9950213:1044 |
| Sentence | TβRI is transphosphorylated by TβRII and propagates the signal by its kinase activity to downstream substrates (4) . |
| Organ | Bone and Bones |
| TextRef | info:pmid/17047049#body:76 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Cancer Res |
| MedLine Reference | 17047049:1075 |
| Sentence | TGFβ proteins signal through binding TGFβ receptor type II (TβRII), which in turn phosphorylates TGFβ receptor type I (TβRI). |
| TextRef | info:pmid/9651680#body:110 |
|---|---|
| PubYear | 1998 |
| MedlineTA | Curr Biol |
| MedLine Reference | 9651680:1109 |
| Sentence | Receptor transphosphorylation is unidirectional in that TGF-βRII phosphorylates TGF-βRI but the converse does not occur [13] and [18]. |
| TextRef | info:pmid/19690145#body:69 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Cancer Res |
| MedLine Reference | 19690145:1068 |
| Sentence | TGF-β binds directly to TGFBR2 and is then recognized by TGFBR1, which is phosphorylated and activated by TGFBR2 (3). |
| TextRef | info:pmid/12492108#body:63 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Mol Cancer Ther |
| MedLine Reference | 12492108:1062 |
| Sentence | When TGF-βRI is phosphorylated by TGF-βRII, Smads 2 and 3 are recruited and in turn are phosphorylated by TGF-βRI. |
| Organ | Bone and Bones |
| TextRef | info:pmid/14500687#body:49 |
|---|---|
| PubYear | 2003 |
| MedlineTA | J Immunol |
| MedLine Reference | 14500687:1048 |
| Sentence | TbetaRII transphosphorylates the glycine/serine-rich domain of TbetaRI kinase (5). |
| Tissue | Extracellular Matrix |
| CellType | Fibroblasts |
| Organ | Skin |
| TextRef | info:pmid/17768179#body:71 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Carcinogenesis |
| MedLine Reference | 17768179:1070 |
| Sentence | Upon ligand binding, TβRII recruits and phosphorylates TβRI, activating its kinase activity to initiate intracellular signaling. |
| Organ | Bone and Bones |
| TextRef | info:pmid/12198207#body:83 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Nephrol Dial Transplant |
| MedLine Reference | 12198207:1082 |
| Sentence | Activated TβR-II transphosphorylates the glycine- and serine-rich domain of the TβR-I kinase, thereby activating TβR-I. |
| TextRef | info:pmid/15561701#body:58 |
|---|---|
| PubYear | 2005 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 15561701:1057 |
| Sentence | A constitutively active kinase domain of TβRII then phosphorylates the glycine-serine domain of TβRI, promoting the activation of the latter receptor (5). |
| TextRef | info:pmid/9916131#body:242 |
|---|---|
| PubYear | 1999 |
| MedlineTA | J Clin Invest |
| MedLine Reference | 9916131:1241 |
| Sentence | In transforming growth factor-β signal transduction, TβR-II phosphorylates TβR-I, which then propagates the signal (28). |
| CellLineName | MDA-MB-231 |
| TextMods | 3: 'TGF' -> 'transforming growth factor' |
| Organ | Thigh |
| TextRef | info:pmid/12118074#body:44 |
|---|---|
| PubYear | 2002 |
| MedlineTA | J Cell Sci |
| MedLine Reference | 12118074:1043 |
| Sentence | TβRII phosphorylates and activates TβRI, which, in turn, phosphorylates receptor-associated Smads (Smad2 and Smad3). CONTEXT{6802426,8802407} |
| TextMods | 94: '(RA) ' -> '' |
| TextRef | info:pmid/12842983#body:43 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Blood |
| MedLine Reference | 12842983:1042 |
| Sentence | TGF-beta ligand binds type I and II receptors in a heterotetrameric complex, whereby TbetaRII phosphorylates the kinase domain of TbetaRI. |
| CellType | Stem Cells |
| TextRef | info:pmid/17197570#body:58 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Am J Respir Cell Mol Biol |
| MedLine Reference | 17197570:1057 |
| Sentence | Upon ligand binding, constitutively active TβRII kinase phosphorylates TβRI/ALK-5 which, in turn, activates the downstream signal transduction cascades. |
| Organ | Lung |
| TextRef | info:pmid/17160136#body:62 |
|---|---|
| PubYear | 2007 |
| MedlineTA | J Clin Invest |
| MedLine Reference | 17160136:1061 |
| Sentence | Once bound to TGF-β, TβRII recruits, binds, and transphosphorylates the type I TGF-β receptor (TβRI), thereby stimulating its protein kinase activity. |
| TextRef | info:pmid/16123810#body:216 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Oncogene |
| MedLine Reference | 16123810:1215 |
| Sentence | The constitutively active TβRII phosphorylates TβRI, which in turn phosphorylates one of the receptor-activated Smads (receptor activated Smads). |
| TextMods | 121: 'R-Smads' -> 'receptor activated Smads' |
| CellType | Epithelial Cells |
| Organ | Intestines |
| TextRef | info:pmid/18222966#body:147 |
|---|---|
| PubYear | 2008 |
| MedlineTA | Exp Biol Med (Maywood) |
| MedLine Reference | 18222966:1146 |
| Sentence | Ligand binding induces the assembly of type I and type II receptors into complexes, within which TGF-β receptor type II phosphorylates and activates TGF-β receptor type I. |
| TextMods | 97: 'TβRII ' -> 'TGF-β receptor type II ' 150: 'TβRI' -> 'TGF-β receptor type I' |
| TextRef | info:pmid/11896591#body:67 |
|---|---|
| PubYear | 2002 |
| MedlineTA | Oncogene |
| MedLine Reference | 11896591:1066 |
| Sentence | TGF-β1 binds to type-II TGF-β cell surface receptors (TβR-II) which, in turn, transphosphorylate type-I receptors (TβR-I). |
| CellType | Insulin-Secreting Cells |
| TextRef | info:pmid/14595120#body:45 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Mol Biol Cell |
| MedLine Reference | 14595120:1044 |
| Sentence | On ligand binding, TβRII transphosphorylates and thereby activates TβRI, which subsequently phosphorylates receptor-regulated Smad , Smad2, and Smad3. |
| TextMods | 133: '(R-Smad)' -> '' |
| TextRef | info:pmid/19144825#body:40 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Mol Biol Cell |
| MedLine Reference | 19144825:1039 |
| Sentence | On ligand binding to the TβRII receptor, TβRII phosphorylates TβRI and activates the TββRI kinase (Wrana et al., 1992[Go]; Chen and Weinberg, 1995[Go]). |
| Organism | Aves |
| TextRef | info:pmid/12456654#body:42 |
|---|---|
| PubYear | 2002 |
| MedlineTA | EMBO J |
| MedLine Reference | 12456654:1041 |
| Sentence | Upon ligand binding, TβRII phosphorylates and activates TβRI, which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. |
| Tissue | Epithelium |
| Organ | Lymphatic System |
| TextRef | info:pmid/16135812#body:45 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Mol Cell Biol |
| MedLine Reference | 16135812:1044 |
| Sentence | TGF-β mediates phosphorylation of TβRI by TβRII, followed by phosphorylation of the R-Smads (Smad2 and -3) by TβRI (2, 43, 65). |
| CellType | Epithelial Cells |
| TextRef | info:pmid/16123802#body:33 |
|---|---|
| PubYear | 2005 |
| MedlineTA | Oncogene |
| MedLine Reference | 16123802:1032 |
| Sentence | TβRII then phosphorylates TβRI in the 'GS sequence' located upstream from the kinase domain, and activates TβRI kinase activity (Shi and Massague, 2003). |
| CellType | Hematopoietic Stem Cells |
| TextRef | info:pmid/19461075#body:50 |
|---|---|
| PubYear | 2009 |
| MedlineTA | J Cell Sci |
| MedLine Reference | 19461075:1049 |
| Sentence | Within this complex, the constitutively active type II TGFβ receptor (TβR-II) phosphorylates and activates the type I TGFβ receptor (TβR-I). |
| Tissue | Blood |
| Organ | Cardiovascular system |
| TextRef | info:pmid/10096559#body:50 |
|---|---|
| PubYear | 1999 |
| MedlineTA | Cancer Res |
| MedLine Reference | 10096559:1049 |
| Sentence | A primary TGF-β-TβRII complex recruits TβRI, which is then phosphorylated in the GS domain by constitutively active TβRII (29) . |
| CellType | Lymphocytes |
| TextRef | info:pmid/19451265#body:68 |
|---|---|
| PubYear | 2009 |
| MedlineTA | J Exp Med |
| MedLine Reference | 19451265:1067 |
| Sentence | Binding of TGF-β to its receptor leads to the activation of the intracellular kinase domain of TGF-βRII, which in turn phosphorylates the kinase domain of the TGF-βRI subunit. |
| Organ | Immune system |
| TextRef | info:pmid/15150118#body:50 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Cancer Res |
| MedLine Reference | 15150118:1049 |
| Sentence | Upon TGF-β1 ligand binding to TβRII, TβRII phosphorylates serine and threonine residues within the GS domain of TβRI, which activates its kinase activity. |
| CellType | Epithelial Cells |
| TextRef | info:pmid/9679060#body:34 |
|---|---|
| PubYear | 1998 |
| MedlineTA | Genes Dev |
| MedLine Reference | 9679060:1033 |
| Sentence | In response to TGF-β binding, the constitutively active type II receptor kinase (TβRII) phosphorylates and activates the TGF-β type I receptor (TβRI) (Wrana et al. 1994; Chen and Weinberg 1995). |
| TextRef | info:pmid/19584284#body:250 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Cancer Res |
| MedLine Reference | 19584284:1249 |
| Sentence | Importantly, in epithelial cells, TGFBR2 can also directly phosphorylate Par6 without involvement of TGFBR1 and release Par6 from the Par6-TGFBR1 complex. |
| CellType | Epithelial Cells |
| TextRef | info:pmid/11884518#body:52 |
|---|---|
| PubYear | 2002 |
| MedlineTA | J Cell Sci |
| MedLine Reference | 11884518:1051 |
| Sentence | Ligand-activated TβR-II phosphorylates TβR-I, which induces intracellular signaling through the modulation and transactivation of Smads (Massague and Chen, 2000; Ten-Dijke et al., 2000). |
| CellType | Epithelial Cells |
| TextRef | info:pmid/11294827#body:771 |
|---|---|
| PubYear | 2001 |
| MedlineTA | Endocr Rev |
| MedLine Reference | 11294827:1770 |
| Sentence | transforming growth factorβ binds to a type II transforming growth factorβ receptor (TβRII), which recruits and phosphorylates a type I transforming growth factorβ receptor (TβRI) (326, 327, 328). |
| TextMods | 0: 'TGF' -> 'transforming growth factor' 48: 'TGF' -> 'transforming growth factor' 139: 'TGF' -> 'transforming growth factor' |
| TextRef | info:pmid/14605008#body:66 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Endocrinology |
| MedLine Reference | 14605008:1065 |
| Sentence | This ligand binding induces TβRII to associate with the TGF-β type I receptor (TβRI), which leads to a unidirectional phosphorylation event in which TβRII phosphorylates TβRI. |
| Organ | Pituitary Gland |
| TextRef | info:pmid/19091788#body:77 |
|---|---|
| PubYear | 2009 |
| MedlineTA | Am J Physiol Renal Physiol |
| MedLine Reference | 19091788:1076 |
| Sentence | The TβRI kinase domain is then phosphorylated by TβRII, and this in turn phosphorylates downstream Smad proteins, which eventually translocate to the nucleus (8). |
| Organ | Renal Tubule |
| TextRef | info:pmid/16177099#body:53 |
|---|---|
| PubYear | 2005 |
| MedlineTA | J Immunol |
| MedLine Reference | 16177099:1052 |
| Sentence | The ligand TGF-β binds the TGF-β transmembrane receptor complex and induces phosphorylation of TGF-βRI by the TGF-βRII kinase, which in turn phosphorylates Smad3. |
| TextMods | 123: '(TGFBRII) ' -> '' |
| CellType | Fibroblasts |
| Organ | Skin |
| TextRef | info:pmid/15961437#body:41 |
|---|---|
| PubYear | 2005 |
| MedlineTA | J Pharmacol Exp Ther |
| MedLine Reference | 15961437:1040 |
| Sentence | This ligand binding induces TGF-βII to associate with the TGF-β3 type I receptor (TβRI), which leads to a unidirectional phosphorylation event in which TβRII phosphorylates TβRI. |
| CellType | Lactotrophs |
| TextRef | info:pmid/10542264#body:32 |
|---|---|
| PubYear | 1999 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 10542264:1031 |
| Sentence | Upon TGF-β binding, the receptors rotate relatively within the complex (8), resulting in phosphorylation of TβRI by the constitutively active and autophosphorylated TβRII and thereby activation of TβRI (2). |
| TextRef | info:pmid/12488458#body:52 |
|---|---|
| PubYear | 2003 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 12488458:1051 |
| Sentence | The cytokine binds to TGFBR-2, which then phosphorylates and activates the TGFBR-1 kinase (1, 32), which, in turn, phosphorylates the receptor-associated Smad2 and Smad3 proteins. |
| CellType | Epithelial Cells |
| Organ | Prostate |
| TextRef | info:pmid/12853969#body:35 |
|---|---|
| PubYear | 2003 |
| MedlineTA | Oncogene |
| MedLine Reference | 12853969:1034 |
| Sentence | Upon ligand binding, TβR-II phosphorylates and activates TβR-I, which directly phosphorylates the receptor-regulated R-Smads (Smad2 and Smad3), which then form a hetero-oligomer with Co-Smad (Smad4). |
| TextRef | info:pmid/8940033#body:54 |
|---|---|
| PubYear | 1996 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 8940033:1053 |
| Sentence | Phosphorylation of TβR-I by TβR-II takes place predominantly in a 30-amino acid long, Gly-Ser-rich juxtamembrane domain that is highly conserved among different type I Receptor serine-threonine kinases. |
| TextMods | 170: 'RSTKs' -> 'Receptor serine-threonine kinases' |
| TextRef | info:pmid/17673906#body:170 |
|---|---|
| PubYear | 2007 |
| MedlineTA | EMBO J |
| MedLine Reference | 17673906:1169 |
| Sentence | As TβRI is phosphorylated by TβRII, it is unclear whether this tyrosine phosphorylation results from TβRI autophosphorylation or from TβRII dual-specificity kinase activity (Lawler et al, 1997). |
| TextRef | info:pmid/14755243#body:39 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Oncogene |
| MedLine Reference | 14755243:1038 |
| Sentence | Mature TGFβ binds to TGFβ type II receptor (TβRII), which phosphorylates and activates a TGFβ type I receptor (TβRI), which in turn phosphorylates Smad2 and Smad3 proteins (Massague et al., 2000). |
| Organ | Mesenchyme |
| TextRef | info:pmid/17615296#body:47 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Mol Biol Cell |
| MedLine Reference | 17615296:1046 |
| Sentence | On ligand-induced heteromeric complex formation between TβR-I and TβR-II, TβR-I is phosphorylated and activated by TβR-II kinase and mediates specific intracellular signaling through phosphorylation of receptor-regulated Smads . |
| TextMods | 231: '(R-Smads)' -> '' |
| TextRef | info:pmid/12039975#body:72 |
|---|---|
| PubYear | 2002 |
| MedlineTA | J Am Soc Nephrol |
| MedLine Reference | 12039975:1071 |
| Sentence | Upon TGF-β binding, the receptors rotate relatively within the complex (11,12), resulting in phosphorylation of TβRI by the constitutively active and autophosphorylated TβRII and thereby activate TβRI. |
| CellType | Epithelial Cells |
| Organ | Renal Tubule |
| TextRef | info:pmid/11583628#body:99 |
|---|---|
| PubYear | 2001 |
| MedlineTA | Mol Cell |
| MedLine Reference | 11583628:1098 |
| Sentence | FKBP12 binds to the unphosphorylated GS regions of type I receptors (Okadome et al. 1996) and (Wang et al. 1994), and buffers TGFβ signaling by blocking ligand-independent phosphorylation of TβR-I by TβR-II (Chen et al., 1997b). |
| TextRef | info:pmid/17596530#body:249 |
|---|---|
| PubYear | 2007 |
| MedlineTA | Am J Physiol Renal Physiol |
| MedLine Reference | 17596530:1248 |
| Sentence | Signaling by these cytokines occurs via ligand-induced heteromeric complex formation of distinct type I (TβRI) and type II (TβRII) receptors and the subsequent phosphorylation of TβRI by TβRII (Fig. 11). |
| Organ | Bone and Bones |
| TextRef | info:pmid/10951568#body:69 |
|---|---|
| PubYear | 2000 |
| MedlineTA | Oncogene |
| MedLine Reference | 10951568:1068 |
| Sentence | Upon ligand binding, the intrinsic serine/threonine kinase of TGFβRII phosphorylates TGFβRI to activate its serine/threonine kinase activity (Wrana et al., 1994; Chen and Weinberg, 1995). |
| Tissue | Epithelium |
| TextRef | info:pmid/16120811#body:56 |
|---|---|
| PubYear | 2005 |
| MedlineTA | J Pharmacol Exp Ther |
| MedLine Reference | 16120811:1055 |
| Sentence | Subsequent phosphorylation of the signaling receptor TβRI by the constitutively active kinase activity of TβRII initiates the phosphorylation and activation of the intracellular mediators Smad2 or Smad3. |
| Tissue | Muscle, Smooth, Vascular |
| Organ | Arteries |
| TextRef | info:pmid/15467747#body:53 |
|---|---|
| PubYear | 2004 |
| MedlineTA | Oncogene |
| MedLine Reference | 15467747:1052 |
| Sentence | Responding to TGF-β binding, type II TGF-β receptor (TβRII), an active type II receptor kinase, phosphorylates and activates type I TGF-β receptor (TβRI) (Wrana et al., 1994; Chen and Weinberg, 1995). |
| CellType | Epithelial Cells |
| TextRef | info:pmid/19010789#body:33 |
|---|---|
| PubYear | 2009 |
| MedlineTA | J Biol Chem |
| MedLine Reference | 19010789:1032 |
| Sentence | Upon ligand-induced heteromeric complex formation between TβR-I and TβR-II, TβR-I is phosphorylated and activated by TβR-II kinase and mediates specific intracellular signaling through phosphorylation on the C-terminal SSXS motif of receptor-regulated Smads . |
| CellLineName | HeLa |
| TextMods | 262: '(R-Smads)' -> '' |
| TextRef | info:pmid/10383147#body:48 |
|---|---|
| PubYear | 1999 |
| MedlineTA | Cancer Res |
| MedLine Reference | 10383147:1047 |
| Sentence | Upon ligand binding, the intrinsic serine/threonine kinase of TGF-βRII phosphorylates TGF-βRI to activate its serine/threonine kinase activity (16 , 17) , and this activated receptor complex transduces TGF-β signals (18) . |
| Organ | Liver |
| TextRef | info:pmid/16973387#body:49 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Immunity |
| MedLine Reference | 16973387:1048 |
| Sentence | Upon binding to their receptors, all three TGF-β isoforms induce kinase activity of the intracellular domain of the common TGF-βRII subunit, which in turn phosphorylates the kinase domain of the TGF-βRI subunit. |
| Tissue | Serum |
| CellType | T-Lymphocytes |
| Organ | Bone Marrow |
| TextRef | info:pmid/18815246#body:261 |
|---|---|
| PubYear | 2008 |
| MedlineTA | J Neurosci |
| MedLine Reference | 18815246:1260 |
| Sentence | TβR-II is required for the transmembrane signaling of transforming growth factor-β1, whereas phosphorylation of TβR-I by TβR-II is required for activating SMAD proteins and propagating the cellular signal downstream of transforming growth factor-β1. |
| TextMods | 55: 'TGF' -> 'transforming growth factor' 223: 'TGF' -> 'transforming growth factor' |
| CellType | Schwann Cells |
| TextRef | info:pmid/9184209#body:42 |
|---|---|
| PubYear | 1997 |
| MedlineTA | EMBO J |
| MedLine Reference | 9184209:1041 |
| Sentence | The type I and type II transfoming growth factors-βs receptors (TβRI and TβRII) are activated by ligand-dependent formation of hetero-oligomeric complexes, in which TβRII transphosphorylates and activates TβRI, thereby initiating the signal transduction cascade (Wrana et al., 1994). |
| TextMods | 23: 'TGF-β ' -> 'transfoming growth factors-βs ' |
| CellType | Keratinocytes |
| Organ | Skin |
| TextRef | info:pmid/16713975#body:74 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Immunity |
| MedLine Reference | 16713975:1073 |
| Sentence | In the presence of active TGF-β, its type II receptor (TGF-βRII) transphosphorylates the type I receptor (TGF-βRI) to phosphorylate receptor-regulated SMADs , i.e., SMAD2 and SMAD3, which in turn form heteromeric complexes with a common-partner SMAD , i.e., SMAD4 (Shi and Massague, 2003 and Wrana et al., 1994). |
| TextMods | 160: '(R-SMADs)' -> '' 253: '(Co-SMAD)' -> '' |
| Tissue | Blood |
| CellType | Killer Cells, Natural |
| TextRef | info:pmid/16675726#body:72 |
|---|---|
| PubYear | 2006 |
| MedlineTA | Arterioscler Thromb Vasc Biol |
| MedLine Reference | 16675726:1071 |
| Sentence | Both the extracellular and intracellular domains of endoglin interact with TβR-II and ALK-5 and its cytoplasmic domain, which is phosphorylated by ALK-5 and TβR-II.11 Deletion of endoglin from endothelial cells potentiates the inhibitory effects of TGF-β on endothelial cell migration and growth, suggesting that it is a negative regulator of TGF-β/ALK-5 signaling. |
| CellType | Endothelial Cells |
| TextRef | info:pmid/9233797#abs:7 |
|---|---|
| MedLine Reference | 9233797:6 |
| Sentence | FKBP12 does not inhibit TbetaR-I association with TbetaR-II, but inhibits TbetaR-I phosphorylation by TbetaR-II. |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/12015308#abs:2 |
|---|---|
| MedLine Reference | 12015308:1 |
| Sentence | Endoglin cannot bind ligand on its own but requires the presence of the signaling receptors, supporting a critical role for the interaction between endoglin and TbetaRI or TbetaRII. |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/9261125#abs:4 |
|---|---|
| MedLine Reference | 9261125:3 |
| Sentence | In the presence of TGF-beta1, TbetaR-I/BMPR-IB and TbetaR-II/ActR-IIB formed heteromeric complexes with wild-type TbetaR-II and TbetaR-I, respectively, upon stable transfection in mink lung epithelial cell lines. |
| Tissue | epithelia |
| Organ | Lung |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/11936776#abs:8 |
|---|---|
| MedLine Reference | 11936776:7 |
| Sentence | Because both TbetaR-I and TbetaR-II are required for signal transduction, the reduction of TbetaR-I levels on the alveolar epithelium may alter the sensitivity of AECs to the antiproliferative effects of TGF-beta1 present in increased quantities following bleomycin injury. |
| Tissue | epithelia |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/12876289#body:27 |
|---|---|
| MedLine Reference | 12876289:1026 |
| Sentence | The constitutively active kinase domain of TbetaRII then activates TbetaRI by transphosphorylation of the GS box in the cytoplasmic domain ( 15 ). |
| Tissue | epithelia |
| Organ | Prostate |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i40 p38342 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/40/38342 |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/9681516#body:44 |
|---|---|
| MedLine Reference | 9681516:1043 |
| Sentence | However, it is not known whether lactotropes express TbetaR-I and whether heteromeric interaction between TbetaR-I and TbetaR-II mediates ligand-dependent gene expression in these cells. |
| Organ | pituitar |
| Journal | Endocrinology |
| Journal Reference | v139 i8 p3620 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/8/3620 |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/11212236#body:128 |
|---|---|
| MedLine Reference | 11212236:1127 |
| Sentence | Previously detected point mutations in TGFBR2 within the kinase domain have been shown to have functional effects that include defective autophosphorylation and hence inhibition of signal transduction, constitutive activation of trans -phosphorylation of TGFBR1 by TGFBR2 (4 , 17) , and generation of a dominant negative form (18) . |
| Journal | Cancer Res |
| Journal Reference | v61 i2 p482 (2001) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/61/2/482 |
| Source | Ariadne Signaling Pathways |
| MedLine Reference | 0:39038327 |
|---|---|
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/14660579#body:32 |
|---|---|
| MedLine Reference | 14660579:1031 |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i8 p6840 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/8/6840 |
| Source | Ariadne Signaling Pathways |
| TextRef | info:pmid/12855402#body:331 |
|---|---|
| MedLine Reference | 12855402:1330 |
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i5 pG1056 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/5/G1056 |
| Source | Ariadne Signaling Pathways |