Elsevier Inc. Dcn A2m Tgfbr3 Smad7 Fkbp1a Smad4 Smad3 ---- Zfyve9 Smad2 Smad3 Translocated Smad Zfyve9 Tgfb1 Tgfbr1 Tgfbr2 Smad7 ---| Tgfbr1 Smurf2 Smurf1 Tgf-beta target genes Transcription factors/co-activators Smad2 ---- Smad4 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Tgfbr2 --+> Tgfbr1 Smad7 ---| Tgfbr1 Smad3 ---- Smad4 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfbr1 --+> Smad2 Tgfbr1 --+> Smad3 Tgfb1 ---- Tgfbr1 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgfb1 ---- Tgfbr2 Smad3 ---> Translocated Smad Smad2 ---> Translocated Smad Smad4 ---> Translocated Smad Translocated Smad ---> Tgf-beta target genes Tgf-beta target genes ---> Smad7