| URN | urn:agi-llid:1361 |
|---|---|
| Total Entities | 0 |
| Connectivity | 395 |
| Name | Cpb2 |
| Description | carboxypeptidase B2 (plasma) |
| Notes | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| metallopeptidase activity | |
| carboxypeptidase activity | |
| metallocarboxypeptidase activity | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | negative regulation of fibrinolysis |
|---|---|
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| liver regeneration | |
| negative regulation of hepatocyte proliferation | |
| positive regulation of extracellular matrix constituent secretion | |
| cellular response to glucose stimulus | |
| response to drug | |
| response to heat | |
| negative regulation of plasminogen activation | |
| proteolysis |
| Pathway | fibrinolysis pathway |
|---|
| Group | negative regulation of fibrinolysis |
|---|---|
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| liver regeneration | |
| negative regulation of hepatocyte proliferation | |
| positive regulation of extracellular matrix constituent secretion | |
| cellular response to glucose stimulus | |
| response to drug | |
| response to heat | |
| negative regulation of plasminogen activation | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| carboxypeptidase activity | |
| metallocarboxypeptidase activity | |
| proteolysis | |
| metal ion binding | |
| zinc ion binding | |
| extracellular region | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1361 |
|---|---|
| 56373 | |
| 113936 |
| Cell Localization | Secreted |
|---|
| GO ID | 0004181 |
|---|---|
| 0008270 | |
| 0007596 | |
| 0042730 | |
| 0051918 | |
| 0006508 | |
| 0042493 | |
| 0009408 | |
| 0005615 | |
| 0004180 | |
| 0016787 | |
| 0046872 | |
| 0008237 | |
| 0008233 | |
| 0007599 | |
| 2000346 | |
| 0010757 | |
| 0003331 | |
| 0005576 | |
| 0071333 | |
| 0097421 |
| Alias | CPU |
|---|---|
| PCPB | |
| TAFI | |
| carboxypeptidase B2 | |
| carboxypeptidase R | |
| carboxypeptidase B-like protein | |
| thrombin-activable fibrinolysis inhibitor | |
| thrombin-activatable fibrinolysis inhibitor | |
| carboxypeptidase B2 (plasma, carboxypeptidase U) | |
| CPR | |
| AI255929 | |
| 1110032P04Rik | |
| 4930405E17Rik | |
| carboxypeptidase U | |
| LOC81954 | |
| RIKEN cDNA 1110032P04 gene | |
| plasma carboxypeptidase B2 isoform a preproprotein | |
| OTTHUMP00000018364 | |
| OTTHUMP00000018365 | |
| plasma carboxypeptidase B2 | |
| MGC107573 | |
| plasma carboxypeptidase B2 isoform b | |
| LOC684726 | |
| RIKEN cDNA 4930405E17 gene | |
| LOC51745 | |
| bA139H14.2 (carboxypeptidase B2 (plasma)) | |
| 1110032P04 | |
| 1110032P04Rik(2) | |
| 4930405E17 | |
| carboxypeptidase B2 (plasma) | |
| 4930405E17Rik_1 | |
| Cpb2 | |
| CPR enzyme |
| Mouse chromosome position | 14 |
|---|
| OMIM ID | 603101 |
|---|
| Rat chromosome position | 15q11 |
|---|
| Hugo ID | 2300 |
|---|
| Human chromosome position | 13q14.11 |
|---|
| Swiss-Prot Accession | Q96IY4 |
|---|---|
| Q9JHH6 | |
| Q9EQV9 | |
| A8K464 | |
| Q15114 | |
| Q5T9K1 | |
| Q5T9K2 | |
| Q9P2Y6 | |
| Q3B7V3 | |
| Q5BKB8 | |
| Q5EBI3 | |
| Q9QZF0 |
| PIR ID | A41204 |
|---|
| Unigene ID | Hs.512937 |
|---|---|
| Mm.24242 | |
| Rn.12572 |
| KEGG ID | hsa:1361 |
|---|---|
| mmu:56373 | |
| rno:113936 |
| Swiss-Prot ID | CBPB2_HUMAN |
|---|---|
| CBPB2_RAT | |
| CBPB2_MOUSE |
| EC Number | 3.4.17.20 |
|---|
| Ensembl ID | ENSG00000080618 |
|---|---|
| ENSP00000400714 | |
| ENST00000439329 | |
| ENSP00000181383 | |
| ENST00000181383 | |
| ENSMUSG00000021999 | |
| ENSMUSP00000022576 | |
| ENSMUST00000022576 | |
| ENSRNOG00000010935 | |
| ENSRNOP00000014909 | |
| ENSRNOT00000014909 |
| Homologene ID | 55610 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1891837 |
|---|
| RGD ID | 71035 |
|---|
| MedScan ID | 1361 |
|---|