Protein Serpinf2

URN	urn:agi-llid:5345
Total Entities	0
Connectivity	346
Name	Serpinf2
Description	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Notes	This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GO Molecular Function	peptidase inhibitor activity
	endopeptidase inhibitor activity
	serine-type endopeptidase inhibitor activity
	protease binding
	protein homodimerization activity

GO Cellular Component	extracellular region
	platelet alpha granule lumen
	fibrinogen complex
	cell surface
	extracellular space

GO Biological Process	positive regulation of collagen biosynthetic process
	positive regulation of JNK cascade
	positive regulation of ERK1 and ERK2 cascade
	positive regulation of transforming growth factor beta production
	negative regulation of fibrinolysis
	fibrinolysis
	blood coagulation
	platelet activation
	regulation of blood vessel size by renin-angiotensin
	blood vessel morphogenesis
	positive regulation of cell differentiation
	positive regulation of stress fiber assembly
	platelet degranulation
	positive regulation of cell-cell adhesion mediated by cadherin
	collagen fibril organization
	positive regulation of smooth muscle cell proliferation
	response to organic substance
	acute-phase response
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of plasminogen activation
	regulation of proteolysis
	negative regulation of peptidase activity
	negative regulation of endopeptidase activity

Pathway	fibrinolysis pathway

Group	positive regulation of collagen biosynthetic process
	positive regulation of JNK cascade
	positive regulation of ERK1 and ERK2 cascade
	positive regulation of transforming growth factor beta production
	negative regulation of fibrinolysis
	fibrinolysis
	blood coagulation
	platelet activation
	regulation of blood vessel size by renin-angiotensin
	blood vessel morphogenesis
	positive regulation of cell differentiation
	positive regulation of stress fiber assembly
	platelet degranulation
	positive regulation of cell-cell adhesion mediated by cadherin
	collagen fibril organization
	positive regulation of smooth muscle cell proliferation
	response to organic substance
	acute-phase response
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of plasminogen activation
	regulation of proteolysis
	peptidase inhibitor activity
	endopeptidase inhibitor activity
	serine-type endopeptidase inhibitor activity
	negative regulation of peptidase activity
	negative regulation of endopeptidase activity
	protease binding
	protein homodimerization activity
	extracellular region
	platelet alpha granule lumen
	fibrinogen complex
	cell surface
	extracellular space
	Secreted proteins
	Biofluids assayable substances

Cell Localization	Secreted

Alias	AAP
	API
	PLI
	A2AP
	ALPHA-2-PI
	alpha-2-antiplasmin
	serpin F2
	alpha-2-AP
	alpha-2-plasmin inhibitor
	serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
	AI747498
	Serpimf2
	RP23-384C18.2
	alpha 2 antiplasmin
	plasmin inhibitor alpha 2
	pigment epithelium derived factor
	serine (or cysteine) proteinase inhibitor, clade F, member 2
	serine (or cysteine) peptidase inhibitor, clade F, member 2
	serine (or cysteine)ase inhibitor, clade F, member II
	serine (or cysteine) protease inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
	serine (or cysteine) protease inhibitor, clade F, member 2
	serine (or cysteine) protease inhibitor, clade F, member II
	serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pi
	antiplasmin alpha 2
	serine (or cysteine)ase inhibitor, clade F, member 2
	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
	SERPINF2
	OTTHUMP00000197009
	serine (or cysteine) protease inhibitor, clade F (alpha-2 antiplasmin, pi
	serine (or cysteine) proteinase inhibitor, clade F, member II
	OTTMUSP00000006500
	OTTHUMP00000115656
	OTTHUMP00000197008
	OTTMUSP00000006499
	plasmin inhibitor alpha II

Mouse chromosome position	11

OMIM ID	613168
	262850

Rat chromosome position	10q24

Hugo ID	9075

Human chromosome position	17p13

PIR ID	S47217
	A31402

Swiss-Prot ID	A2AP_MOUSE
	A2AP_HUMAN

Homologene ID	719

MGI ID	107173

RGD ID	1306692

MedScan ID	5345