| URN | urn:agi-llid:5329 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1545 |
| Name | Plaur |
| Description | plasminogen activator, urokinase receptor |
| Notes | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | urokinase plasminogen activator receptor activity |
|---|---|
| transferase activity | |
| kinase activity | |
| receptor activity | |
| enzyme binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| integral component of membrane | |
| anchored component of membrane | |
| extrinsic component of membrane | |
| integral component of plasma membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum lumen | |
| cell surface | |
| plasma membrane |
| GO Biological Process | epithelial cell differentiation involved in prostate gland development |
|---|---|
| spermatogenesis | |
| attachment of GPI anchor to protein | |
| fibrinolysis | |
| blood coagulation | |
| mesenchymal cell differentiation | |
| skeletal muscle tissue regeneration | |
| cellular component movement | |
| signal transduction | |
| urokinase plasminogen activator signaling pathway | |
| negative regulation of apoptotic process | |
| chemotaxis | |
| positive regulation of gene expression | |
| regulation of proteolysis | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| C-terminal protein lipidation | |
| phosphorylation |
| Pathway | Mechanism of Cetuximab Resistance in Colorectal Cancer |
|---|---|
| Proteins Involved in Pathogenesis of Melanoma | |
| Melanoma Overview | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Glioma Invasion Signaling | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of HIV Type 1 Infection | |
| Proteins Involved in Pathogenesis of Osteoarthritis | |
| Proteins Involved in Pathogenesis of Gout | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| UrokinaseR -> ELK-SRF signaling | |
| UrokinaseR -> STAT signaling | |
| TGFB1-TGFBR2 Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| PLAU/ELK-SRF/AP-1 Expression Targets | |
| PLAU/STAT1 Expression Targets | |
| FGF1/STAT Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| IGF2/STAT Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| S1P Expression Targets | |
| EDN1 Expression Targets | |
| TCR/AP-1 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| IGF1/STAT Expression Targets | |
| VEGFA/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| IL1B/NO Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| fibrinolysis pathway |
| Group | uPAR |
|---|---|
| epithelial cell differentiation involved in prostate gland development | |
| spermatogenesis | |
| attachment of GPI anchor to protein | |
| fibrinolysis | |
| blood coagulation | |
| mesenchymal cell differentiation | |
| skeletal muscle tissue regeneration | |
| cellular component movement | |
| signal transduction | |
| urokinase plasminogen activator receptor activity | |
| urokinase plasminogen activator signaling pathway | |
| negative regulation of apoptotic process | |
| chemotaxis | |
| positive regulation of gene expression | |
| regulation of proteolysis | |
| transferase activity | |
| kinase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| C-terminal protein lipidation | |
| phosphorylation | |
| receptor activity | |
| enzyme binding | |
| membrane | |
| extracellular region | |
| integral component of membrane | |
| anchored component of membrane | |
| extrinsic component of membrane | |
| integral component of plasma membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum lumen | |
| cell surface | |
| plasma membrane | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5329 |
|---|---|
| 18793 | |
| 50692 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane | |
| Secreted |
| GO ID | 0019899 |
|---|---|
| 0004872 | |
| 0030377 | |
| 0006501 | |
| 0016255 | |
| 0007596 | |
| 0006928 | |
| 0044267 | |
| 0006935 | |
| 0042730 | |
| 0043687 | |
| 0030162 | |
| 0007165 | |
| 0031225 | |
| 0005788 | |
| 0005789 | |
| 0005576 | |
| 0019898 | |
| 0016021 | |
| 0005887 | |
| 0005886 | |
| 0016301 | |
| 0016740 | |
| 0060742 | |
| 0048762 | |
| 0043066 | |
| 0016310 | |
| 0010628 | |
| 0038195 | |
| 0016020 | |
| 0043403 | |
| 0007283 | |
| 0009986 |
| Alias | CD87 |
|---|---|
| UPAR | |
| URKR | |
| U-PAR | |
| urokinase plasminogen activator surface receptor | |
| monocyte activation antigen Mo3 | |
| u-plasminogen activator receptor form 2 | |
| urokinase-type plasminogen activator (uPA) receptor | |
| urokinase plasminogen activator receptor | |
| urokinase-type plasminogen activator receptor | |
| Par | |
| Plaur3 | |
| uPAR-2 | |
| uPAR-3 | |
| urinary plasminogen activator receptor 2 | |
| urinary plasminogen activator receptor 3 | |
| plasminogen activator urokinase receptor 3 | |
| Plasminogen activator, urokinase receptor | |
| u-plasminogen activator receptor form 1 | |
| uPAR IIs | |
| UPAR_HUMAN | |
| Urokinase plasminogen activator surface receptor, GPI-anchored form precur | |
| urokinase receptor | |
| urokinase receptors | |
| uPA receptor | |
| uPAR III | |
| 2210407C18 | |
| CD87 antigen | |
| Monocyte activating antigen MO3 | |
| plasminogen activator receptor | |
| plasminogen activator receptors | |
| MO3 | |
| PLAUR | |
| plasminogen activator, urokinase receptor III | |
| Plasminogen activator, urokinase receptors | |
| uPAR II |
| Mouse chromosome position | 7 |
|---|
| OMIM ID | 173391 |
|---|
| Rat chromosome position | 1q21 |
|---|
| Hugo ID | 9053 |
|---|
| Human chromosome position | 19q13 |
|---|
| Swiss-Prot Accession | Q03405 |
|---|---|
| M0R1I2 | |
| P35456 | |
| Q545X5 | |
| P49616 | |
| P35457 | |
| A8K409 | |
| Q12876 | |
| Q15845 | |
| Q16887 | |
| Q6IB52 | |
| Q9BWT0 | |
| Q9NYC8 | |
| Q9UD69 | |
| Q9UEA6 | |
| Q9UM92 | |
| Q9UMV0 | |
| O35771 | |
| P51573 | |
| Q7TN35 |
| PIR ID | A55356 |
|---|---|
| B41643 | |
| I52614 | |
| S12376 | |
| S39495 | |
| S42152 | |
| S42429 |
| Unigene ID | Hs.466871 |
|---|---|
| Mm.1359 | |
| Rn.82711 |
| KEGG ID | hsa:5329 |
|---|---|
| mmu:18793 | |
| rno:50692 |
| Swiss-Prot ID | UPAR_MOUSE |
|---|---|
| UPAR_HUMAN | |
| UPAR_RAT |
| Ensembl ID | ENSG00000011422 |
|---|---|
| ENSP00000342049 | |
| ENST00000339082 | |
| ENSP00000221264 | |
| ENST00000221264 | |
| ENSP00000339328 | |
| ENST00000340093 | |
| ENSP00000471881 | |
| ENST00000601723 | |
| ENSMUSG00000046223 | |
| ENSMUSP00000002284 | |
| ENSMUST00000002284 |
| Homologene ID | 48120 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97612 |
|---|
| RGD ID | 620597 |
|---|
| MedScan ID | 5329 |
|---|