| URN | urn:agi-llid:5328 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2585 |
| Name | Plau |
| Description | plasminogen activator, urokinase |
| Notes | This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| transferase activity | |
| kinase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| cell surface | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | spermatogenesis |
|---|---|
| positive regulation of ovulation | |
| embryo implantation | |
| fibrinolysis | |
| blood coagulation | |
| angiogenesis | |
| regulation of hepatocyte proliferation | |
| skeletal muscle tissue regeneration | |
| signal transduction | |
| regulation of receptor activity | |
| regulation of cell adhesion mediated by integrin | |
| regulation of smooth muscle cell-matrix adhesion | |
| cellular response to glucose stimulus | |
| regulation of smooth muscle cell migration | |
| positive regulation of smooth muscle cell migration | |
| smooth muscle cell migration | |
| neuron death | |
| positive regulation of cell proliferation | |
| regulation of cell proliferation | |
| response to activity | |
| chemotaxis | |
| cellular response to lipopolysaccharide | |
| cellular response to organic substance | |
| cellular response to hepatocyte growth factor stimulus | |
| cellular response to staurosporine | |
| cellular response to hypoxia | |
| response to hepatocyte growth factor | |
| response to hypoxia | |
| response to hyperoxia | |
| wound healing | |
| regulation of wound healing | |
| cellular response to fluid shear stress | |
| positive regulation of reactive oxygen species metabolic process | |
| phosphorylation | |
| proteolysis |
| Pathway | Proliferative Diabetic Retinopathy |
|---|---|
| Role of Hexosamine Pathway in Diabetic Microangiopathy | |
| Role of Advanced Glycation End Products Pathway in Diabetic Microangiopathy | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Proteins Involved in Pathogenesis of Melanoma | |
| Melanoma Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| RAGE/AGER and S100 Proteins in Cardiovascular Injury in Atherosclerosis | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Glioma Invasion Signaling | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of HIV Type 1 Infection | |
| Proteins Involved in Pathogenesis of Osteoarthritis | |
| Proteins Involved in Pathogenesis of Gout | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Nociception-related IL1B expression targets | |
| UrokinaseR -> ELK-SRF signaling | |
| UrokinaseR -> STAT signaling | |
| ROS in Triggering Vascular Inflammation | |
| TGFB1-TGFBR2 Expression Targets | |
| BDNF Expression Targets | |
| LTA Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| PLAU/ELK-SRF/AP-1 Expression Targets | |
| PLAU/STAT1 Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| NRG1/Catenin Expression Targets | |
| NRG1/STAT Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/EP300/ETS/ETV/SP1 Expression Targets | |
| TGFA/CTNNB/CTNND Expression Targets | |
| TGFA/STAT Expression Targets | |
| FGF1/STAT Expression Targets | |
| CSF1/STAT Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| FGF4/AP-1/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| GAST Expression Targets | |
| FSHR Expression Targets | |
| EDN1 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| IGF1/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| VEGFA/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1A Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TNF/NF-kB Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| fibrinolysis pathway |
| Group | PLA |
|---|---|
| spermatogenesis | |
| positive regulation of ovulation | |
| embryo implantation | |
| fibrinolysis | |
| blood coagulation | |
| angiogenesis | |
| regulation of hepatocyte proliferation | |
| skeletal muscle tissue regeneration | |
| signal transduction | |
| regulation of receptor activity | |
| regulation of cell adhesion mediated by integrin | |
| regulation of smooth muscle cell-matrix adhesion | |
| cellular response to glucose stimulus | |
| regulation of smooth muscle cell migration | |
| positive regulation of smooth muscle cell migration | |
| smooth muscle cell migration | |
| neuron death | |
| positive regulation of cell proliferation | |
| regulation of cell proliferation | |
| response to activity | |
| chemotaxis | |
| cellular response to lipopolysaccharide | |
| cellular response to organic substance | |
| cellular response to hepatocyte growth factor stimulus | |
| cellular response to staurosporine | |
| cellular response to hypoxia | |
| response to hepatocyte growth factor | |
| response to hypoxia | |
| response to hyperoxia | |
| wound healing | |
| regulation of wound healing | |
| cellular response to fluid shear stress | |
| positive regulation of reactive oxygen species metabolic process | |
| catalytic activity | |
| hydrolase activity | |
| transferase activity | |
| kinase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| phosphorylation | |
| proteolysis | |
| membrane | |
| extracellular region | |
| cell surface | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5328 |
|---|---|
| 18792 | |
| 25619 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0004252 |
|---|---|
| 0007596 | |
| 0006935 | |
| 0042730 | |
| 0006508 | |
| 0033628 | |
| 0042127 | |
| 0010469 | |
| 0014910 | |
| 2000097 | |
| 0061041 | |
| 0001666 | |
| 0007165 | |
| 0014909 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0016301 | |
| 0008233 | |
| 0008236 | |
| 0016740 | |
| 0001525 | |
| 0070997 | |
| 0016310 | |
| 0008284 | |
| 0060279 | |
| 2000379 | |
| 0014911 | |
| 2000345 | |
| 0043403 | |
| 0042060 | |
| 0016020 | |
| 0071498 | |
| 0071333 | |
| 0035729 | |
| 0071456 | |
| 0071222 | |
| 0071310 | |
| 0072734 | |
| 0007566 | |
| 0014823 | |
| 0035728 | |
| 0055093 | |
| 0007283 |
| Alias | ATF |
|---|---|
| QPD | |
| UPA | |
| URK | |
| u-PA | |
| BDPLT5 | |
| RP11-417O11.1 | |
| urokinase-type plasminogen activator | |
| U-plasminogen activator | |
| plasminogen activator, urinary | |
| UPAM | |
| Urinary plasminogen activator, urokinase | |
| two-chain urokinase-type plasminogen activators | |
| urokinase plasminogen activator | |
| two-chain urokinase-type plasminogen activator | |
| U- plasminogen activator | |
| urinary esterase A | |
| urinary plasminogen activator | |
| urinary plasminogen activators | |
| urokinase PA | |
| urokinases | |
| LOC143706 | |
| urokinase | |
| double-chain urokinase-type plasminogen activator | |
| MGC124931 | |
| prourokinases | |
| abbokinase | |
| antagonist of upa | |
| cellular plasminogen activators | |
| double-chain urokinase-type plasminogen activators | |
| LOC115418 | |
| plasminogen activator, urokinase | |
| prourokinase | |
| cellular plasminogen activator | |
| PLAU | |
| LOC118484 | |
| OTTHUMP00000019850 | |
| OTTHUMP00000019849 | |
| LOC95176 |
| Mouse chromosome position | 14 11.53 cM |
|---|
| OMIM ID | 191840 |
|---|---|
| 104300 | |
| 601709 |
| Rat chromosome position | 15p16 |
|---|
| Hugo ID | 9052 |
|---|
| Human chromosome position | 10q22.2 |
|---|
| Swiss-Prot Accession | P00749 |
|---|---|
| Q59GZ8 | |
| P06869 | |
| Q0VBA8 | |
| Q3KR76 | |
| P29598 | |
| B4DPZ2 | |
| Q15844 | |
| Q16618 | |
| Q53XS3 | |
| Q5SWW9 | |
| Q969W6 |
| PIR ID | A29420 |
|---|---|
| A00931 |
| Unigene ID | Hs.77274 |
|---|---|
| Mm.4183 | |
| Rn.6064 |
| KEGG ID | hsa:5328 |
|---|---|
| mmu:18792 | |
| rno:25619 |
| Swiss-Prot ID | UROK_MOUSE |
|---|---|
| UROK_HUMAN |
| EC Number | 3.4.21.73 |
|---|
| Ensembl ID | ENSG00000122861 |
|---|---|
| ENSP00000388474 | |
| ENST00000446342 | |
| ENSP00000361850 | |
| ENST00000372764 | |
| ENSMUSG00000021822 | |
| ENSMUSP00000022368 | |
| ENSMUST00000022368 | |
| ENSRNOG00000010516 | |
| ENSRNOP00000014273 | |
| ENSRNOT00000014273 |
| Homologene ID | 55670 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97611 |
|---|
| RGD ID | 3343 |
|---|
| MedScan ID | 5328 |
|---|