| URN | urn:agi-llid:5327 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2478 |
| Name | Plat |
| Description | plasminogen activator, tissue |
| Notes | This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | extracellular matrix |
|---|---|
| synapse | |
| extracellular region | |
| cell surface | |
| apical part of cell | |
| cytoplasm | |
| secretory granule | |
| extracellular space |
| GO Biological Process | positive regulation of ovulation |
|---|---|
| fibrinolysis | |
| blood coagulation | |
| platelet-derived growth factor receptor signaling pathway | |
| synaptic transmission, glutamatergic | |
| regulation of synaptic plasticity | |
| smooth muscle cell migration | |
| response to cAMP | |
| response to peptide hormone | |
| response to glucocorticoid | |
| response to hypoxia | |
| wound healing | |
| negative regulation of proteolysis | |
| cellular protein modification process | |
| proteolysis | |
| plasminogen activation |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Proliferative Diabetic Retinopathy | |
| Role of Hexosamine Pathway in Diabetic Microangiopathy | |
| Role of Advanced Glycation End Products Pathway in Diabetic Microangiopathy | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Proteins Involved in Pathogenesis of Vasospasm | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| fibrinolysis pathway |
| Group | PLA |
|---|---|
| positive regulation of ovulation | |
| fibrinolysis | |
| blood coagulation | |
| platelet-derived growth factor receptor signaling pathway | |
| synaptic transmission, glutamatergic | |
| regulation of synaptic plasticity | |
| smooth muscle cell migration | |
| response to cAMP | |
| response to peptide hormone | |
| response to glucocorticoid | |
| response to hypoxia | |
| wound healing | |
| negative regulation of proteolysis | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein modification process | |
| proteolysis | |
| plasminogen activation | |
| extracellular matrix | |
| synapse | |
| extracellular region | |
| cell surface | |
| apical part of cell | |
| cytoplasm | |
| secretory granule | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5327 |
|---|---|
| 18791 | |
| 25692 |
| Cell Localization | Extracellular |
|---|---|
| Secreted | |
| Extracellular space |
| GO ID | 0004252 |
|---|---|
| 0007596 | |
| 0006464 | |
| 0042730 | |
| 0045861 | |
| 0031639 | |
| 0048008 | |
| 0060279 | |
| 0006508 | |
| 0048167 | |
| 0051591 | |
| 0051384 | |
| 0001666 | |
| 0043434 | |
| 0014909 | |
| 0035249 | |
| 0045177 | |
| 0009986 | |
| 0005737 | |
| 0031012 | |
| 0005576 | |
| 0005615 | |
| 0030141 | |
| 0045202 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0042060 |
| Alias | TPA |
|---|---|
| T-PA | |
| tissue-type plasminogen activator | |
| alteplase | |
| reteplase | |
| t-plasminogen activator | |
| plasminogen activator, tissue type | |
| tissue plasminogen activator (t-PA) | |
| AU020998 | |
| AW212668 | |
| D8Ertd2e | |
| PATISS | |
| tissue plasminogen activator | |
| tPA antigen | |
| t-PA antigen | |
| ak 124 | |
| angiokinase | |
| hapase | |
| plasvata | |
| tissue type plasminogen activator | |
| tisokinase | |
| DNA segment, Chr 8, ERATO Doi 2, expressed | |
| angiochinase | |
| tissue plasminogen activator antigen | |
| DKFZp686I03148 | |
| MGC18508 | |
| plasminogen activator, tissue | |
| plasminogen tissue activator | |
| PLAT | |
| tissue PA |
| Mouse chromosome position | 8 11.42 cM |
|---|
| OMIM ID | 173370 |
|---|---|
| 612348 |
| Rat chromosome position | 16q12.5 |
|---|
| Hugo ID | 9051 |
|---|
| Human chromosome position | 8p12 |
|---|
| Swiss-Prot Accession | P00750 |
|---|---|
| B4DNJ1 | |
| B4DN26 | |
| P11214 | |
| P19637 | |
| A8K022 | |
| B2R8E8 | |
| Q15103 | |
| Q503B0 | |
| Q6PJA5 | |
| Q7Z7N2 | |
| Q86YK8 | |
| Q9BU99 | |
| Q9BZW1 | |
| Q6P7U0 | |
| Q91VP2 |
| PIR ID | A94004 |
|---|---|
| I38098 | |
| A29941 | |
| A35029 |
| Unigene ID | Hs.491582 |
|---|---|
| Mm.154660 | |
| Rn.107102 |
| KEGG ID | hsa:5327 |
|---|---|
| mmu:18791 | |
| rno:25692 |
| Swiss-Prot ID | TPA_HUMAN |
|---|---|
| TPA_MOUSE | |
| TPA_RAT |
| EC Number | 3.4.21.68 |
|---|
| Ensembl ID | ENSG00000104368 |
|---|---|
| ENSP00000220809 | |
| ENST00000220809 | |
| ENSP00000270188 | |
| ENST00000352041 | |
| ENSP00000392045 | |
| ENST00000429089 | |
| ENSMUSG00000031538 | |
| ENSMUSP00000033941 | |
| ENSMUST00000033941 | |
| ENSRNOG00000019018 | |
| ENSRNOP00000025764 | |
| ENSRNOT00000025763 |
| Homologene ID | 717 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97610 |
|---|
| RGD ID | 3342 |
|---|
| MedScan ID | 5327 |
|---|