| URN | urn:agi-llid:5340 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2482 |
| Name | Plg |
| Description | plasminogen |
| Notes | The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| apolipoprotein binding | |
| protein domain specific binding |
| GO Cellular Component | extracellular region |
|---|---|
| extrinsic component of plasma membrane | |
| extrinsic component of external side of plasma membrane | |
| platelet alpha granule lumen | |
| cell surface | |
| plasma membrane | |
| intracellular membrane-bounded organelle | |
| extracellular space |
| GO Biological Process | mononuclear cell migration |
|---|---|
| tissue remodeling | |
| negative regulation of fibrinolysis | |
| fibrinolysis | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| negative regulation of angiogenesis | |
| labyrinthine layer blood vessel development | |
| trophoblast giant cell differentiation | |
| tissue regeneration | |
| myoblast differentiation | |
| platelet degranulation | |
| negative regulation of cell-cell adhesion mediated by cadherin | |
| negative regulation of cell-substrate adhesion | |
| muscle cell cellular homeostasis | |
| extracellular matrix disassembly | |
| apoptotic process | |
| extracellular matrix organization | |
| negative regulation of cell proliferation | |
| cellular protein metabolic process | |
| proteolysis involved in cellular protein catabolic process | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Alzheimer's Disease Overview | |
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Traffic and Degradation of Extracellular Amyloid beta in Alzheimer's Disease | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Glioma Invasion Signaling | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of Cataract | |
| ThrombinR -> STAT1 signaling | |
| ThrombinR -> NF-kB signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| fibrinolysis pathway |
| Group | ITGL |
|---|---|
| mononuclear cell migration | |
| tissue remodeling | |
| negative regulation of fibrinolysis | |
| fibrinolysis | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| negative regulation of angiogenesis | |
| labyrinthine layer blood vessel development | |
| trophoblast giant cell differentiation | |
| tissue regeneration | |
| myoblast differentiation | |
| platelet degranulation | |
| negative regulation of cell-cell adhesion mediated by cadherin | |
| negative regulation of cell-substrate adhesion | |
| muscle cell cellular homeostasis | |
| extracellular matrix disassembly | |
| apoptotic process | |
| extracellular matrix organization | |
| negative regulation of cell proliferation | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| proteolysis involved in cellular protein catabolic process | |
| proteolysis | |
| apolipoprotein binding | |
| protein domain specific binding | |
| extracellular region | |
| extrinsic component of plasma membrane | |
| extrinsic component of external side of plasma membrane | |
| platelet alpha granule lumen | |
| cell surface | |
| plasma membrane | |
| intracellular membrane-bounded organelle | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5340 |
|---|---|
| 18815 | |
| 85253 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0034185 |
|---|---|
| 0019904 | |
| 0004252 | |
| 0006915 | |
| 0007596 | |
| 0044267 | |
| 0022617 | |
| 0030198 | |
| 0042730 | |
| 0060716 | |
| 0071674 | |
| 0046716 | |
| 0045445 | |
| 0008285 | |
| 2000048 | |
| 0010812 | |
| 0051918 | |
| 0030168 | |
| 0002576 | |
| 0051919 | |
| 0051603 | |
| 0042246 | |
| 0048771 | |
| 0060707 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0031232 | |
| 0005886 | |
| 0031093 | |
| 0003824 | |
| 0004175 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0016525 | |
| 0006508 | |
| 0019897 | |
| 0043231 |
| Alias | RP1-81D8.1 |
|---|---|
| plasminogen | |
| plasmin | |
| Pg | |
| AI649309 | |
| angiostatin | |
| plasmin heavy chain A | |
| plasmin light chain B | |
| Ab1-346 | |
| thrombolysin | |
| plasmins | |
| Plg | |
| serum tryptases | |
| OTTHUMP00000017544 | |
| thrombolysins | |
| serum tryptase | |
| actase | |
| plasmin activity | |
| actasess | |
| DKFZp779m0222 | |
| fibrinase | |
| fibrinases | |
| fibrinolysin | |
| fibrinolysins | |
| LOC90749 | |
| microplasmin | |
| miniplasmin | |
| actases |
| Mouse chromosome position | 17 8.5 cM |
|---|
| OMIM ID | 173350 |
|---|---|
| 217090 |
| Rat chromosome position | 1q11 |
|---|
| Hugo ID | 9071 |
|---|
| Human chromosome position | 6q26 |
|---|
| Swiss-Prot Accession | P00747 |
|---|---|
| Q5TEH5 | |
| P20918 | |
| Q3V1T9 | |
| Q01177 | |
| Q15146 | |
| Q5TEH4 | |
| Q6PA00 | |
| Q8CIS2 | |
| Q91WJ5 | |
| Q5BKB6 | |
| Q9R0W3 |
| PIR ID | A35229 |
|---|---|
| A38514 | |
| A40522 |
| Unigene ID | Hs.143436 |
|---|---|
| Mm.971 | |
| Rn.20178 |
| KEGG ID | hsa:5340 |
|---|---|
| mmu:18815 | |
| rno:85253 |
| Swiss-Prot ID | PLMN_HUMAN |
|---|---|
| PLMN_MOUSE | |
| PLMN_RAT |
| EC Number | 3.4.21.7 |
|---|
| Ensembl ID | ENSG00000122194 |
|---|---|
| ENSP00000355891 | |
| ENST00000366924 | |
| ENSMUSG00000059481 | |
| ENSMUSP00000014578 | |
| ENSMUST00000014578 | |
| ENSRNOG00000017223 | |
| ENSRNOP00000023370 | |
| ENSRNOT00000023368 |
| Homologene ID | 55452 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97620 |
|---|
| RGD ID | 619893 |
|---|
| MedScan ID | 5340 |
|---|