| URN | urn:agi-llid:2153 |
|---|---|
| Total Entities | 0 |
| Connectivity | 935 |
| Name | F5 |
| Description | coagulation factor V (proaccelerin, labile factor) |
| Notes | This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008] |
| GO Molecular Function | serine-type endopeptidase activity |
|---|---|
| metal ion binding | |
| copper ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| platelet alpha granule lumen | |
| plasma membrane | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| platelet alpha granule | |
| extracellular space |
| GO Biological Process | blood coagulation, extrinsic pathway |
|---|---|
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| blood circulation | |
| cell adhesion | |
| platelet degranulation |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Inflammatory Bowel Diseases | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| coagulation cascade pathway |
| Group | Coagulation factor |
|---|---|
| blood coagulation, extrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| blood circulation | |
| cell adhesion | |
| platelet degranulation | |
| serine-type endopeptidase activity | |
| metal ion binding | |
| copper ion binding | |
| extracellular region | |
| platelet alpha granule lumen | |
| plasma membrane | |
| Golgi apparatus | |
| endoplasmic reticulum | |
| platelet alpha granule | |
| extracellular space | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2153 |
|---|---|
| 14067 | |
| 304929 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0005507 |
|---|---|
| 0008015 | |
| 0007596 | |
| 0007155 | |
| 0030168 | |
| 0002576 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0031093 | |
| 0046872 | |
| 0004252 | |
| 0007599 | |
| 0005794 | |
| 0005783 | |
| 0031091 | |
| 0007598 |
| Alias | FVL |
|---|---|
| PCCF | |
| THPH2 | |
| RPRGL1 | |
| coagulation factor V | |
| factor V Leiden | |
| proaccelerin, labile factor | |
| activated protein c cofactor | |
| coagulation factor V jinjiang A2 domain | |
| Cf5 | |
| Cf-5 | |
| AI173222 | |
| Ac2-120 | |
| FACTOR V | |
| plasma ac globulin | |
| proaccelerin | |
| labile factor | |
| OTTHUMP00000032547 | |
| OTTHUMP00000032548 | |
| ac globulin | |
| accelerator globulin | |
| owren factor | |
| intrinsic prothrombin activator | |
| blood factor v | |
| blood clotting factor 5 | |
| blood clotting factor V | |
| blood coagulation factor 5 | |
| coagulation factor V (proaccelerin, labile factor) | |
| clotting factor 5 | |
| clotting factor v | |
| plasma prothrombin conversion factor | |
| Blood-coagulation factor V | |
| Cf V | |
| coagulating factor V (proaccelerin, labile factor) | |
| coagulation factor 5 | |
| Coagulation factor F5 |
| Mouse chromosome position | 1 71.46 cM |
|---|
| OMIM ID | 612309 |
|---|---|
| 600880 | |
| 227400 | |
| 601367 | |
| 614389 | |
| 188055 |
| Rat chromosome position | 13q22 |
|---|
| Hugo ID | 3542 |
|---|
| Human chromosome position | 1q23 |
|---|
| Swiss-Prot Accession | P12259 |
|---|---|
| O88783 | |
| Q7TPK2 | |
| A8K6E8 | |
| Q14285 | |
| Q2EHR5 | |
| Q5R346 | |
| Q5R347 | |
| Q6UPU6 | |
| Q8WWQ6 | |
| Q3UTQ2 | |
| Q3UV80 |
| PIR ID | A56172 |
|---|---|
| T42764 |
| Unigene ID | Hs.30054 |
|---|---|
| Mm.12900 | |
| Rn.82910 |
| KEGG ID | hsa:2153 |
|---|---|
| mmu:14067 | |
| rno:304929 |
| Swiss-Prot ID | FA5_HUMAN |
|---|---|
| FA5_MOUSE |
| Ensembl ID | ENSMUSG00000026579 |
|---|---|
| ENSMUSP00000083204 | |
| ENSMUST00000086040 | |
| ENSRNOG00000002815 | |
| ENSRNOP00000031747 | |
| ENSRNOT00000033157 |
| Homologene ID | 104 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88382 |
|---|
| RGD ID | 1589758 |
|---|
| MedScan ID | 2153 |
|---|