| URN | urn:agi-llid:2160 |
|---|---|
| Total Entities | 0 |
| Connectivity | 320 |
| Name | F11 |
| Description | coagulation factor XI |
| Notes | This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| serine-type aminopeptidase activity | |
| heparin binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | blood coagulation, intrinsic pathway |
|---|---|
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| proteolysis | |
| plasminogen activation |
| Pathway | Coagulation Cascade |
|---|---|
| coagulation cascade pathway |
| Group | Coagulation factor |
|---|---|
| blood coagulation, intrinsic pathway | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| serine-type aminopeptidase activity | |
| proteolysis | |
| plasminogen activation | |
| heparin binding | |
| membrane | |
| extracellular region | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2160 |
|---|---|
| 109821 | |
| 290757 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0008201 |
|---|---|
| 0070009 | |
| 0004252 | |
| 0007596 | |
| 0007597 | |
| 0031639 | |
| 0051919 | |
| 0006508 | |
| 0005576 | |
| 0005615 | |
| 0016020 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0030193 |
| Alias | FXI |
|---|---|
| coagulation factor XI | |
| PTA | |
| plasma thromboplastin antecedent | |
| Cf11 | |
| AI503996 | |
| 1600027G01Rik | |
| LRRGT00086 | |
| blood clotting factor 11 | |
| clotting factor xi | |
| blood coagulation factor 11 | |
| blood coagulation factor xi | |
| blood thromboplastin antecedent | |
| clotting factor 11 | |
| coagulating factor XI (plasma thromboplastin antecedent) | |
| coagulation factor XI (plasma thromboplastin antecedent) | |
| factor XI | |
| plasma coagulation factor 11 | |
| RIKEN cDNA 1600027G01 gene | |
| platelet coagulation factor XI isoform b | |
| plasma coagulation factor XI | |
| 1600027G01 | |
| blood clotting factor XI | |
| platelet coagulation factor XI | |
| F11 gene | |
| factor XIa | |
| MGC141891 | |
| OTTHUMP00000218130 | |
| plasma coagulating factor XI precursor isoform a | |
| plasma coagulation factor XI precursor isoform a | |
| LOC201924 | |
| platelet coagulating factor XI isoform b | |
| platelet coagulation factor 11 |
| Mouse chromosome position | 8 25.14 cM |
|---|
| OMIM ID | 264900 |
|---|---|
| 612416 |
| Rat chromosome position | 16q11 |
|---|
| Hugo ID | 3529 |
|---|
| Human chromosome position | 4q35 |
|---|
| Swiss-Prot Accession | P03951 |
|---|---|
| Q91Y47 | |
| Q6TUF8 | |
| Q9DAT3 | |
| D3DP64 | |
| Q4W5C2 | |
| Q9Y495 |
| PIR ID | A27431 |
|---|
| Unigene ID | Hs.1430 |
|---|---|
| Mm.33326 | |
| Rn.162292 |
| KEGG ID | hsa:2160 |
|---|---|
| mmu:109821 | |
| rno:290757 |
| Swiss-Prot ID | FA11_MOUSE |
|---|---|
| FA11_HUMAN |
| EC Number | 3.4.21.27 |
|---|
| Ensembl ID | ENSG00000088926 |
|---|---|
| ENSP00000264692 | |
| ENST00000264692 | |
| ENSP00000384957 | |
| ENST00000403665 | |
| ENSMUSG00000031645 | |
| ENSMUSP00000034064 | |
| ENSMUST00000034064 | |
| ENSRNOG00000013684 | |
| ENSRNOP00000044970 | |
| ENSRNOT00000041946 |
| Homologene ID | 86654 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 99481 |
|---|
| RGD ID | 1309364 |
|---|
| MedScan ID | 2160 |
|---|