| URN | urn:agi-llid:2159 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1425 |
| Name | F10 |
| Description | coagulation factor X |
| Notes | This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| phospholipid binding | |
| calcium ion binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| intrinsic component of external side of plasma membrane | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| intracellular membrane-bounded organelle |
| GO Biological Process | blood coagulation, intrinsic pathway |
|---|---|
| blood coagulation, extrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| positive regulation of protein kinase B signaling | |
| positive regulation of cell migration | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Vitamin K metabolism | |
| coagulation cascade pathway |
| Group | Coagulation factor |
|---|---|
| blood coagulation, intrinsic pathway | |
| blood coagulation, extrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| positive regulation of protein kinase B signaling | |
| positive regulation of cell migration | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| phospholipid binding | |
| calcium ion binding | |
| membrane | |
| extracellular region | |
| intrinsic component of external side of plasma membrane | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2159 |
|---|---|
| 14058 | |
| 29243 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0005509 |
|---|---|
| 0005543 | |
| 0004252 | |
| 0007596 | |
| 0007598 | |
| 0007597 | |
| 0044267 | |
| 0017187 | |
| 0030335 | |
| 0051897 | |
| 0043687 | |
| 0006508 | |
| 0005796 | |
| 0005788 | |
| 0005576 | |
| 0031233 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0043231 | |
| 0016020 |
| Alias | FX |
|---|---|
| FXA | |
| RP11-98F14.9 | |
| coagulation factor X | |
| factor Xa | |
| prothrombinase | |
| Stuart-Prower factor | |
| Cf10 | |
| stuart factor | |
| coagulation factor 10 | |
| plasma thromboplastins | |
| prothrombases | |
| OTTMUSP00000043610 | |
| prothrombase | |
| AI194738 | |
| thrombokinase | |
| factor X | |
| plasma thromboplastin | |
| autoprothrombin C | |
| autoprotrombine C | |
| blood clotting factor 10 | |
| blood clotting factor X | |
| blood coagulation factor x | |
| blood factor X | |
| clotting factor 10 | |
| clotting factor X | |
| serum factor X | |
| factor 10 | |
| OTTMUSP00000022651 | |
| activated factor X | |
| MGC108722 | |
| activated blood-coagulating factor 10 | |
| activated blood-coagulating factor X | |
| OTTMUSP00000022500 | |
| activated blood-coagulation factor X | |
| activated Stuart-Prower factor | |
| activated stuart-prower factors | |
| alpha Xa | |
| beta Xa | |
| coagukation factor Xa | |
| activated blood-coagulating factor xes | |
| coagulating factor 10 | |
| OTTMUSP00000022499 | |
| OTTHUMP00000018735 | |
| factor F10 | |
| coagulation factor Xa | |
| coagulating factor xas | |
| coagulating factor Xa | |
| coagulating factor X | |
| OTTHUMP00000202678 |
| Mouse chromosome position | 8 5.73 cM |
|---|
| OMIM ID | 613872 |
|---|---|
| 227600 |
| Rat chromosome position | 16q12.5 |
|---|
| Hugo ID | 3528 |
|---|
| Human chromosome position | 13q34 |
|---|
| Swiss-Prot Accession | P00742 |
|---|---|
| Q5JVE7 | |
| Q5JVE8 | |
| Q3U3V1 | |
| Q80Y26 | |
| O88947 | |
| Q3TBR2 | |
| Q63207 | |
| Q14340 | |
| O54740 | |
| Q99L32 |
| PIR ID | S49075 |
|---|---|
| A24478 |
| Unigene ID | Hs.361463 |
|---|---|
| Mm.262589 | |
| Rn.21393 |
| KEGG ID | hsa:2159 |
|---|---|
| mmu:14058 | |
| rno:29243 |
| Swiss-Prot ID | FA10_RAT |
|---|---|
| FA10_HUMAN | |
| FA10_MOUSE |
| EC Number | 3.4.21.6 |
|---|
| Ensembl ID | ENSG00000126218 |
|---|---|
| ENSP00000364709 | |
| ENST00000375559 | |
| ENSP00000364701 | |
| ENST00000375551 | |
| ENSMUSG00000031444 | |
| ENSMUSP00000068389 | |
| ENSMUST00000063820 | |
| ENSRNOG00000033444 | |
| ENSRNOP00000026677 | |
| ENSRNOT00000026677 |
| Homologene ID | 30976 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 103107 |
|---|
| RGD ID | 61850 |
|---|
| MedScan ID | 2159 |
|---|