| URN | urn:agi-llid:2158 |
|---|---|
| Total Entities | 0 |
| Connectivity | 185 |
| Name | F9 |
| Description | coagulation factor IX |
| Notes | This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| calcium ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane |
| GO Biological Process | blood coagulation, intrinsic pathway |
|---|---|
| blood coagulation, extrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Vitamin K metabolism | |
| coagulation cascade pathway |
| Group | Coagulation factor |
|---|---|
| blood coagulation, intrinsic pathway | |
| blood coagulation, extrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| calcium ion binding | |
| extracellular region | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2158 |
|---|---|
| 14071 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0005509 |
|---|---|
| 0004252 | |
| 0007596 | |
| 0007598 | |
| 0007597 | |
| 0044267 | |
| 0017187 | |
| 0043687 | |
| 0006508 | |
| 0005796 | |
| 0005788 | |
| 0005576 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 |
| Alias | FIX |
|---|---|
| P19 | |
| PTC | |
| HEMB | |
| THPH8 | |
| RP6-88D7.1 | |
| coagulation factor IX | |
| F9 p22 | |
| FIX F9 | |
| factor 9 | |
| factor IX F9 | |
| Christmas factor | |
| plasma thromboplastic component | |
| plasma thromboplastin component | |
| Cf9 | |
| Cf-9 | |
| AW111646 | |
| RP23-419J18.1 | |
| antihemophilia b globulin | |
| OTTHUMP00000024154 | |
| autoprothrombin II | |
| factor antihaemophilic b | |
| thrombocyte cofactor 2 | |
| antihemophilia b factor | |
| autoprothrombin 2 | |
| antihemophilic factor b | |
| antihemophilia b | |
| MGC129642 | |
| fxases | |
| clotting factor 9 | |
| blood clotting factor 1x | |
| LOC158996 | |
| MGC129641 | |
| blood clotting factor 9 | |
| blood clotting factor IX | |
| blood factor ix | |
| clotting factor ix | |
| Cf IX | |
| Christmas disease, hemophilia B gene | |
| coagulation factor 9 | |
| Coagulation factor F9 | |
| Coagulation factor IX (plasma thromboplastic component) | |
| Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | |
| Factor IXa | |
| fxase | |
| coagulant factor ix | |
| blood coagulation factor ix |
| Mouse chromosome position | X 33.5 cM |
|---|
| OMIM ID | 300746 |
|---|---|
| 306900 | |
| 300807 | |
| 122700 |
| Hugo ID | 3551 |
|---|
| Human chromosome position | Xq27.1-q27.2 |
|---|
| Swiss-Prot Accession | P00740 |
|---|---|
| P16294 | |
| Q3UES1 | |
| A8K9N4 | |
| F2RM36 | |
| Q5FBE1 | |
| Q5JYJ8 |
| PIR ID | JQ0419 |
|---|---|
| A00922 |
| Unigene ID | Hs.522798 |
|---|---|
| Mm.391283 |
| KEGG ID | hsa:2158 |
|---|---|
| mmu:14071 |
| Swiss-Prot ID | FA9_MOUSE |
|---|---|
| FA9_HUMAN |
| EC Number | 3.4.21.22 |
|---|
| Ensembl ID | ENSG00000101981 |
|---|---|
| ENSP00000218099 | |
| ENST00000218099 | |
| ENSP00000377650 | |
| ENST00000394090 | |
| ENSMUSG00000031138 | |
| ENSMUSP00000033477 | |
| ENSMUST00000033477 |
| Homologene ID | 106 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 88384 |
|---|
| RGD ID | 2589 |
|---|
| MedScan ID | 2158 |
|---|