| URN | urn:agi-llid:2155 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1001 |
| Name | F7 |
| Description | coagulation factor VII (serum prothrombin conversion accelerator) |
| Notes | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| glycoprotein binding | |
| receptor binding | |
| calcium ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| extracellular space | |
| vesicle |
| GO Biological Process | positive regulation of leukocyte chemotaxis |
|---|---|
| blood coagulation, extrinsic pathway | |
| positive regulation of blood coagulation | |
| hemostasis | |
| blood coagulation | |
| organ regeneration | |
| positive regulation of protein kinase B signaling | |
| positive regulation of platelet-derived growth factor receptor signaling pathway | |
| positive regulation of cell migration | |
| response to growth hormone | |
| response to vitamin K | |
| response to hormone | |
| response to organic cyclic compound | |
| response to estrogen | |
| positive regulation of positive chemotaxis | |
| response to nutrient levels | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| circadian rhythm |
| Pathway | Coagulation Cascade |
|---|---|
| Vitamin K metabolism | |
| coagulation cascade pathway |
| Group | Coagulation factor |
|---|---|
| positive regulation of leukocyte chemotaxis | |
| blood coagulation, extrinsic pathway | |
| positive regulation of blood coagulation | |
| hemostasis | |
| blood coagulation | |
| organ regeneration | |
| positive regulation of protein kinase B signaling | |
| positive regulation of platelet-derived growth factor receptor signaling pathway | |
| positive regulation of cell migration | |
| response to growth hormone | |
| response to vitamin K | |
| response to hormone | |
| response to organic cyclic compound | |
| response to estrogen | |
| positive regulation of positive chemotaxis | |
| response to nutrient levels | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| circadian rhythm | |
| glycoprotein binding | |
| receptor binding | |
| calcium ion binding | |
| extracellular region | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| plasma membrane | |
| extracellular space | |
| vesicle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2155 |
|---|---|
| 14068 | |
| 260320 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0005509 |
|---|---|
| 0001948 | |
| 0005102 | |
| 0004252 | |
| 0008236 | |
| 0007596 | |
| 0007598 | |
| 0044267 | |
| 0007623 | |
| 0031100 | |
| 0017187 | |
| 0030194 | |
| 0030335 | |
| 0002690 | |
| 0010641 | |
| 0050927 | |
| 0051897 | |
| 0043687 | |
| 0006508 | |
| 0043627 | |
| 0060416 | |
| 0032571 | |
| 0005796 | |
| 0005788 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0031982 | |
| 0003824 | |
| 0004175 | |
| 0016787 | |
| 0008233 | |
| 0007599 | |
| 0009725 | |
| 0031667 | |
| 0014070 |
| Alias | SPCA |
|---|---|
| coagulation factor VII | |
| eptacog alfa | |
| proconvertin | |
| FVII coagulation protein | |
| Cf7 | |
| FVII | |
| mfVII | |
| AI132620 | |
| serum prothrombin conversion accelerator | |
| autoprothrombine 1 | |
| blood clotting factor VII | |
| blood factor VII | |
| clotting factor 7 | |
| clotting factor VII | |
| coagulating factor 7 | |
| coagulating factor VII | |
| coagulating factor VII (serum prothrombin conversion accelerator) | |
| blood clotting factor 7 | |
| cogulation factor VII | |
| autoprothrombin 1 | |
| plasma clotting factor VII | |
| coagulation factor 7 | |
| proconvertine | |
| coagulation factor F7 | |
| factor VII | |
| coagulation factor VII (serum prothrombin conversion accelerator) | |
| rFVIIa | |
| blood coagulation factor vii | |
| coagulating factor VII precursor isoform a | |
| coagulating factor VII precursor isoform b | |
| coagulating factor VIIa | |
| coagulation factor VII precursor isoform a | |
| coagulation factor VII precursor isoform b | |
| coagulation factor VIIa | |
| OTTHUMP00000018734 | |
| FA7_HUMAN | |
| FVIIa | |
| OTTMUSP00000022498 | |
| OTTHUMP00000018733 | |
| FA7 |
| Mouse chromosome position | 8 5.73 cM |
|---|
| OMIM ID | 613878 |
|---|---|
| 227500 | |
| 608446 |
| Rat chromosome position | 16q12.5 |
|---|
| Hugo ID | 3544 |
|---|
| Human chromosome position | 13q34 |
|---|
| Swiss-Prot Accession | P08709 |
|---|---|
| B4DPM2 | |
| P70375 | |
| Q542C2 | |
| Q8K3U6 | |
| B0YJC8 | |
| Q14339 | |
| Q5JVF1 | |
| Q5JVF2 | |
| Q9UD52 | |
| Q9UD53 | |
| Q9UD54 | |
| Q61109 |
| PIR ID | A28322 |
|---|
| Unigene ID | Hs.36989 |
|---|---|
| Mm.4827 | |
| Rn.86416 |
| KEGG ID | hsa:2155 |
|---|---|
| mmu:14068 | |
| rno:260320 |
| Swiss-Prot ID | FA7_HUMAN |
|---|---|
| FA7_MOUSE | |
| FA7_RAT |
| EC Number | 3.4.21.21 |
|---|
| Ensembl ID | ENSG00000057593 |
|---|---|
| ENSP00000364731 | |
| ENST00000375581 | |
| ENSMUSG00000031443 | |
| ENSMUSP00000033820 | |
| ENSMUST00000033820 | |
| ENSRNOG00000032737 | |
| ENSRNOP00000038466 | |
| ENSRNOT00000037806 |
| Homologene ID | 7710 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 109325 |
|---|
| RGD ID | 628678 |
|---|
| MedScan ID | 2155 |
|---|