| URN | urn:agi-llid:2152 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2227 |
| Name | F3 |
| Description | coagulation factor III (thromboplastin, tissue factor) |
| Notes | This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| GO Molecular Function | protease binding |
|---|---|
| phospholipid binding |
| GO Cellular Component | extracellular matrix |
|---|---|
| membrane | |
| integral component of membrane | |
| intrinsic component of external side of plasma membrane | |
| cell surface | |
| plasma membrane | |
| cytoplasm | |
| extracellular space |
| GO Biological Process | blood coagulation, extrinsic pathway |
|---|---|
| activation of blood coagulation via clotting cascade | |
| hemostasis | |
| blood coagulation | |
| positive regulation of angiogenesis | |
| aging | |
| positive regulation of protein kinase B signaling | |
| positive regulation of platelet-derived growth factor receptor signaling pathway | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell migration | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| positive regulation of endothelial cell proliferation | |
| response to lipopolysaccharide | |
| cellular response to hydrogen peroxide | |
| response to estradiol | |
| response to low-density lipoprotein particle | |
| positive regulation of positive chemotaxis | |
| response to fluid shear stress | |
| response to wounding | |
| activation of plasma proteins involved in acute inflammatory response | |
| response to mechanical stimulus | |
| response to temperature stimulus |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Systemic Lupus Erythematosus | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Vitamin K metabolism | |
| ROS in Triggering Vascular Inflammation | |
| TGFB1-TGFBR2 Expression Targets | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR1/2/6 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| ICAM1 Expression Targets | |
| Fibronectin Expression Targets | |
| FCGR3A Expression Targets | |
| IL6 Expression Targets | |
| LIF Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| IFNG-IFNR Expression Targets | |
| OSM-OSMR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| HMGB1 Expression Targets | |
| TGFA/CTNNB/CTNND Expression Targets | |
| TGFA/STAT Expression Targets | |
| CSF1/STAT Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| Thromboxane A2 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| Serotonin/Gq Expression Targets | |
| Epinephrine/Gq Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| S1P Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| AGT/ELK-SRF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| VEGFA/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| coagulation cascade pathway |
| Group | Receptors |
|---|---|
| Coagulation factor | |
| blood coagulation, extrinsic pathway | |
| activation of blood coagulation via clotting cascade | |
| hemostasis | |
| blood coagulation | |
| positive regulation of angiogenesis | |
| aging | |
| positive regulation of protein kinase B signaling | |
| positive regulation of platelet-derived growth factor receptor signaling pathway | |
| positive regulation of cell migration | |
| positive regulation of smooth muscle cell migration | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| positive regulation of endothelial cell proliferation | |
| response to lipopolysaccharide | |
| cellular response to hydrogen peroxide | |
| response to estradiol | |
| response to low-density lipoprotein particle | |
| positive regulation of positive chemotaxis | |
| response to fluid shear stress | |
| response to wounding | |
| activation of plasma proteins involved in acute inflammatory response | |
| response to mechanical stimulus | |
| response to temperature stimulus | |
| protease binding | |
| phospholipid binding | |
| extracellular matrix | |
| membrane | |
| integral component of membrane | |
| intrinsic component of external side of plasma membrane | |
| cell surface | |
| plasma membrane | |
| cytoplasm | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2152 |
|---|---|
| 14066 | |
| 25584 |
| Cell Localization | Plasma membrane |
|---|---|
| Extracellular | |
| Membrane | |
| Secreted |
| GO ID | 0005543 |
|---|---|
| 0002020 | |
| 0002543 | |
| 0006919 | |
| 0002541 | |
| 0007596 | |
| 0007598 | |
| 0045766 | |
| 0030335 | |
| 0001938 | |
| 0010641 | |
| 0050927 | |
| 0051897 | |
| 0009986 | |
| 0031012 | |
| 0005615 | |
| 0016021 | |
| 0031233 | |
| 0005886 | |
| 0007599 | |
| 0014911 | |
| 0005737 | |
| 0016020 | |
| 0007568 | |
| 0070301 | |
| 0032355 | |
| 0034405 | |
| 0032496 | |
| 0055098 | |
| 0009612 | |
| 0009266 | |
| 0009611 |
| Alias | TF |
|---|---|
| TFA | |
| CD142 | |
| tissue factor | |
| Cf3 | |
| Cf-3 | |
| AA409063 | |
| coagulation factor 3 | |
| thromborel s | |
| thromboplastin 2 | |
| blood clotting factor iii | |
| tissue thromboplastin | |
| epsilon tachostypan | |
| neoplastin | |
| simplastin excel | |
| thromboplastin 1 | |
| thromboplastin 3 | |
| thromboplastin 4 | |
| thromboplastin 5 | |
| thromboplastin b | |
| blood clotting factor 3 | |
| thromborel | |
| blood coagulating factor 3 | |
| thromboplastine | |
| epsilon thromboplastin | |
| CD142 antigen | |
| Cf III | |
| coagulating factor 3 | |
| coagulating factor F3 | |
| coagulating factor III | |
| TF_HUMAN | |
| Coagulation factor F3 | |
| Thromboplastin | |
| OTTHUMP00000012426 | |
| MGC93621 | |
| FLJ17960 | |
| coagulation factor III (thromboplastin, tissue factor) | |
| Coagulation factor III |
| Mouse chromosome position | 3 52.94 cM |
|---|
| OMIM ID | 134390 |
|---|
| Rat chromosome position | 2q41 |
|---|
| Hugo ID | 3541 |
|---|
| Human chromosome position | 1p22-p21 |
|---|
| Swiss-Prot Accession | P13726 |
|---|---|
| P20352 | |
| Q66HI4 | |
| P42533 | |
| D3DT47 | |
| Q6FHG2 | |
| Q86WH4 |
| PIR ID | A43645 |
|---|---|
| A32318 |
| Unigene ID | Hs.62192 |
|---|---|
| Mm.273188 | |
| Rn.9980 |
| KEGG ID | hsa:2152 |
|---|---|
| mmu:14066 | |
| rno:25584 |
| Swiss-Prot ID | TF_HUMAN |
|---|---|
| TF_MOUSE |
| Ensembl ID | ENSG00000117525 |
|---|---|
| ENSP00000359226 | |
| ENST00000370207 | |
| ENSP00000334145 | |
| ENST00000334047 | |
| ENSMUSG00000028128 | |
| ENSMUSP00000029771 | |
| ENSMUST00000029771 | |
| ENSRNOG00000011800 | |
| ENSRNOP00000015836 | |
| ENSRNOT00000015836 |
| Homologene ID | 1511 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88381 |
|---|
| RGD ID | 2587 |
|---|
| MedScan ID | 2152 |
|---|