| URN | urn:agi-llid:8858 |
|---|---|
| Total Entities | 0 |
| Connectivity | 181 |
| Name | Proz |
| Description | protein Z, vitamin K-dependent plasma glycoprotein |
| Notes | This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| GO Molecular Function | catalytic activity |
|---|---|
| serine-type endopeptidase activity | |
| calcium ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| Golgi lumen | |
| endoplasmic reticulum lumen |
| GO Biological Process | hemostasis |
|---|---|
| blood coagulation | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| Vitamin K metabolism | |
| coagulation cascade pathway |
| Group | hemostasis |
|---|---|
| blood coagulation | |
| catalytic activity | |
| serine-type endopeptidase activity | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| proteolysis | |
| calcium ion binding | |
| extracellular region | |
| Golgi lumen | |
| endoplasmic reticulum lumen | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 8858 |
|---|---|
| 66901 |
| Cell Localization | Secreted |
|---|
| GO ID | 0005509 |
|---|---|
| 0004252 | |
| 0007596 | |
| 0044267 | |
| 0017187 | |
| 0043687 | |
| 0006508 | |
| 0005796 | |
| 0005788 | |
| 0005576 | |
| 0003824 | |
| 0007599 |
| Alias | PZ |
|---|---|
| vitamin K-dependent protein Z | |
| 1300015B06Rik | |
| vitamin K-dependent plasma glycoprotein | |
| protein Z, vitamin K-dependent plasma glycoprotein | |
| protein Z | |
| vitamin K-dependent plasma glycoprotein Z | |
| OTTHUMP00000018738 | |
| 1300015B06 | |
| Proz |
| Mouse chromosome position | 8 |
|---|
| OMIM ID | 176895 |
|---|---|
| 614024 |
| Hugo ID | 9460 |
|---|
| Human chromosome position | 13q34 |
|---|
| Swiss-Prot Accession | P22891 |
|---|---|
| Q9CQW3 | |
| A6NMB4 | |
| Q15213 | |
| Q5JVF5 | |
| Q5JVF6 |
| PIR ID | A36244 |
|---|
| Unigene ID | Hs.1011 |
|---|---|
| Mm.441140 |
| KEGG ID | hsa:8858 |
|---|---|
| mmu:66901 |
| Swiss-Prot ID | PROZ_MOUSE |
|---|---|
| PROZ_HUMAN |
| Ensembl ID | ENSG00000126231 |
|---|---|
| ENSP00000344458 | |
| ENST00000342783 | |
| ENSP00000364697 | |
| ENST00000375547 | |
| ENSMUSG00000031445 | |
| ENSMUSP00000033822 | |
| ENSMUST00000033822 |
| Homologene ID | 2890 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 1860488 |
|---|
| RGD ID | 1308666 |
|---|
| MedScan ID | 8858 |
|---|