| URN | urn:agi-llid:7035 |
|---|---|
| Total Entities | 0 |
| Connectivity | 648 |
| Name | Tfpi |
| Description | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| Notes | This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | peptidase inhibitor activity |
|---|---|
| endopeptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity |
| GO Cellular Component | extracellular region |
|---|---|
| anchored component of membrane | |
| organelle membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| extracellular space |
| GO Biological Process | blood coagulation, extrinsic pathway |
|---|---|
| hemostasis | |
| blood coagulation | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| coagulation cascade pathway |
| Group | blood coagulation, extrinsic pathway |
|---|---|
| hemostasis | |
| blood coagulation | |
| peptidase inhibitor activity | |
| endopeptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity | |
| extracellular region | |
| anchored component of membrane | |
| organelle membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7035 |
|---|---|
| 21788 | |
| 29436 |
| Cell Localization | Secreted |
|---|---|
| Microsome membrane |
| GO ID | 0004866 |
|---|---|
| 0004867 | |
| 0007596 | |
| 0007598 | |
| 0010951 | |
| 0031225 | |
| 0005783 | |
| 0005576 | |
| 0005615 | |
| 0031090 | |
| 0005886 | |
| 0030414 | |
| 0007599 | |
| 0010466 |
| Alias | EPI |
|---|---|
| TFI | |
| LACI | |
| TFPI1 | |
| tissue factor pathway inhibitor | |
| anti-convertin | |
| extrinsic pathway inhibitor | |
| AW552122 | |
| A630013F22Rik | |
| RP23-202K13.2 | |
| lipoprotein-associated coagulation inhibitor | |
| tfpi | |
| TFPI I | |
| tissue factor pathway inhibitor (lipoprotein-associated coagulating inhibit | |
| tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibit | |
| tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | |
| OTTMUSP00000014389 | |
| antithromboplastin | |
| OTTHUMP00000205424 | |
| RIKEN cDNA A630013F22 gene | |
| extrinsic coagulation pathway inhibitor | |
| A630013F22 | |
| OTTHUMP00000205431 | |
| OTTMUSP00000014388 | |
| Lipoprotein-associated coagulating inhibitor | |
| OTTHUMP00000163472 | |
| OTTHUMP00000205429 | |
| OTTMUSP00000014384 | |
| OTTMUSP00000014385 | |
| OTTMUSP00000014386 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 152310 |
|---|
| Rat chromosome position | 3q24 |
|---|
| Hugo ID | 11760 |
|---|
| Human chromosome position | 2q32 |
|---|
| Swiss-Prot Accession | P10646 |
|---|---|
| Q8BSB7 | |
| O54819 | |
| Q5PQU8 | |
| Q02445 | |
| Q9Z2U8 | |
| O95103 | |
| Q53TS4 |
| PIR ID | JX0213 |
|---|---|
| A23712 |
| Unigene ID | Hs.516578 |
|---|---|
| Mm.124316 | |
| Mm.447013 | |
| Rn.15795 |
| KEGG ID | hsa:7035 |
|---|---|
| mmu:21788 | |
| rno:29436 |
| Swiss-Prot ID | TFPI1_MOUSE |
|---|---|
| TFPI1_RAT | |
| TFPI1_HUMAN |
| Ensembl ID | ENSG00000003436 |
|---|---|
| ENSP00000342306 | |
| ENST00000339091 | |
| ENSP00000233156 | |
| ENST00000233156 | |
| ENSP00000376172 | |
| ENST00000392365 | |
| ENSP00000386344 | |
| ENST00000409676 | |
| ENSMUSG00000027082 | |
| ENSMUSP00000107343 | |
| ENSMUST00000111714 | |
| ENSMUSP00000088235 | |
| ENSMUST00000090732 | |
| ENSMUSP00000028487 | |
| ENSMUST00000028487 | |
| ENSMUSP00000107351 | |
| ENSMUST00000111722 | |
| ENSMUSP00000107347 | |
| ENSMUST00000111718 | |
| ENSRNOG00000005039 | |
| ENSRNOP00000006787 | |
| ENSRNOT00000006787 |
| Homologene ID | 4579 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1095418 |
|---|
| RGD ID | 61914 |
|---|
| MedScan ID | 7035 |
|---|