| URN | urn:agi-llid:462 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1428 |
| Name | Serpinc1 |
| Description | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| Notes | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| GO Molecular Function | peptidase inhibitor activity |
|---|---|
| serine-type endopeptidase inhibitor activity | |
| protease binding | |
| heparin binding |
| GO Cellular Component | extracellular region |
|---|---|
| plasma membrane | |
| extracellular space |
| GO Biological Process | regulation of blood coagulation, intrinsic pathway |
|---|---|
| hemostasis | |
| blood coagulation | |
| response to nutrient | |
| negative regulation of inflammatory response | |
| regulation of proteolysis | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity |
| Pathway | Coagulation Cascade |
|---|---|
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| coagulation cascade pathway |
| Group | regulation of blood coagulation, intrinsic pathway |
|---|---|
| hemostasis | |
| blood coagulation | |
| response to nutrient | |
| negative regulation of inflammatory response | |
| regulation of proteolysis | |
| peptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity | |
| protease binding | |
| heparin binding | |
| extracellular region | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 462 |
|---|---|
| 11905 | |
| 304917 |
| Cell Localization | Secreted |
|---|---|
| Extracellular space |
| GO ID | 0008201 |
|---|---|
| 0002020 | |
| 0004867 | |
| 0007596 | |
| 0010951 | |
| 0050728 | |
| 2000266 | |
| 0030162 | |
| 0007584 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0030414 | |
| 0007599 | |
| 0010466 |
| Alias | AT3 |
|---|---|
| AT3D | |
| ATIII | |
| THPH7 | |
| PRO0309 | |
| antithrombin-III | |
| serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 | |
| At-3 | |
| AI114908 | |
| serpin C1 | |
| antithrombin | |
| anti-thrombin 3 | |
| serpin peptidase inhibitor, clade C, member 1 | |
| antithrombin III | |
| serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | |
| serine (or cysteine) protease inhibitor, clade C (antithrombin), member I | |
| serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member I | |
| SERPINC I | |
| SERPINC1 | |
| signal peptide antithrombin part 1 | |
| heparin cofactor I | |
| serine-cysteine proteinase inhibitor clade C member 1 | |
| serpin peptidase inhibitor, clade C (antithrombin), member 1 | |
| anthrobin p | |
| coding sequence signal peptide antithrombin part 1 | |
| antithrombin (aa 375-432) | |
| serine-cysteine protease inhibitor clade C member 1 | |
| AT-III | |
| OTTHUMP00000035393 | |
| serine (or cysteine) protease inhibitor, clade C (antithrombin), member 1 | |
| MGC22579 |
| Mouse chromosome position | 1 69.75 cM |
|---|
| OMIM ID | 107300 |
|---|---|
| 613118 |
| Rat chromosome position | 13q22 |
|---|
| Hugo ID | 775 |
|---|
| Human chromosome position | 1q25.1 |
|---|
| Swiss-Prot Accession | P01008 |
|---|---|
| P32261 | |
| Q543J5 | |
| Q5M7T5 | |
| B2R6P0 | |
| P78439 | |
| P78447 | |
| Q13815 | |
| Q5TC78 | |
| Q7KZ43 | |
| Q7KZ97 | |
| Q9UC78 |
| PIR ID | A49494 |
|---|
| Unigene ID | Hs.75599 |
|---|---|
| Mm.260770 | |
| Rn.204806 |
| KEGG ID | hsa:462 |
|---|---|
| mmu:11905 | |
| rno:304917 |
| Swiss-Prot ID | ANT3_HUMAN |
|---|---|
| ANT3_MOUSE |
| Ensembl ID | ENSG00000117601 |
|---|---|
| ENSP00000356671 | |
| ENST00000367698 | |
| ENSMUSG00000026715 | |
| ENSMUSP00000068971 | |
| ENSMUST00000064725 | |
| ENSRNOG00000002783 | |
| ENSRNOP00000003748 | |
| ENSRNOT00000003748 |
| Homologene ID | 20139 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88095 |
|---|
| RGD ID | 1307404 |
|---|
| MedScan ID | 462 |
|---|