| URN | urn:agi-llid:7450 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1780 |
| Name | Vwf |
| Description | von Willebrand factor |
| Notes | The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | chaperone binding |
|---|---|
| glycoprotein binding | |
| protein N-terminus binding | |
| collagen binding | |
| integrin binding | |
| immunoglobulin binding | |
| protease binding | |
| protein homodimerization activity |
| GO Cellular Component | extracellular matrix |
|---|---|
| extracellular region | |
| external side of plasma membrane | |
| platelet alpha granule lumen | |
| endoplasmic reticulum | |
| Weibel-Palade body | |
| platelet alpha granule | |
| proteinaceous extracellular matrix |
| GO Biological Process | blood coagulation, intrinsic pathway |
|---|---|
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| liver development | |
| placenta development | |
| tissue regeneration | |
| cell adhesion | |
| platelet degranulation | |
| cell-substrate adhesion | |
| response to wounding | |
| response to immobilization stress | |
| protein homooligomerization |
| Pathway | Proteins Involved in Pathogenesis of Atherosclerosis |
|---|---|
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| coagulation cascade pathway |
| Group | ITGL |
|---|---|
| blood coagulation, intrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| platelet activation | |
| liver development | |
| placenta development | |
| tissue regeneration | |
| cell adhesion | |
| platelet degranulation | |
| cell-substrate adhesion | |
| response to wounding | |
| response to immobilization stress | |
| protein homooligomerization | |
| chaperone binding | |
| glycoprotein binding | |
| protein N-terminus binding | |
| collagen binding | |
| integrin binding | |
| immunoglobulin binding | |
| protease binding | |
| protein homodimerization activity | |
| extracellular matrix | |
| extracellular region | |
| external side of plasma membrane | |
| platelet alpha granule lumen | |
| endoplasmic reticulum | |
| Weibel-Palade body | |
| platelet alpha granule | |
| proteinaceous extracellular matrix | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7450 |
|---|---|
| 22371 | |
| 116669 |
| Cell Localization | Extracellular |
|---|---|
| Secreted | |
| Extracellular space | |
| Extracellular matrix |
| GO ID | 0051087 |
|---|---|
| 0005518 | |
| 0001948 | |
| 0019865 | |
| 0005178 | |
| 0002020 | |
| 0047485 | |
| 0042803 | |
| 0007596 | |
| 0007597 | |
| 0007155 | |
| 0031589 | |
| 0007599 | |
| 0001889 | |
| 0001890 | |
| 0030168 | |
| 0002576 | |
| 0051260 | |
| 0009611 | |
| 0033093 | |
| 0005783 | |
| 0009897 | |
| 0031012 | |
| 0005576 | |
| 0031091 | |
| 0031093 | |
| 0005578 | |
| 0035902 | |
| 0042246 |
| Alias | VWD |
|---|---|
| F8VWF | |
| von Willebrand factor | |
| coagulation factor VIII VWF | |
| AI551257 | |
| C630030D09 | |
| 6820430P06Rik | |
| B130011O06Rik | |
| RIKEN cDNA B130011O06 gene | |
| Von Willebrand factor homolog | |
| vWF | |
| blood clotting factor 8 related antigen | |
| blood clotting factor VIII related antigen | |
| factor 8 related antigen | |
| factor 8 related protein | |
| van willebrand factor | |
| factor VIII-related antigen | |
| Von Willebrand factor precursor (vWF) | |
| Willebrand factor | |
| OTTMUSP00000025031 | |
| B130011O06 | |
| Coagulation factor VIII VWF (von Willebrand factor) | |
| FVIII-rA | |
| 6820430P06 | |
| LOC213549 |
| Mouse chromosome position | 6 59.32 cM |
|---|
| OMIM ID | 613160 |
|---|---|
| 193400 | |
| 613554 | |
| 277480 |
| Rat chromosome position | 4q42 |
|---|
| Hugo ID | 12726 |
|---|
| Human chromosome position | 12p13.3 |
|---|
| Swiss-Prot Accession | P04275 |
|---|---|
| Q8CIZ8 | |
| F5XVC1 | |
| Q62935 | |
| Q99806 | |
| Q60863 | |
| Q6XUV6 | |
| Q8BIU9 | |
| Q8CGN0 | |
| Q9JK16 |
| PIR ID | A34480 |
|---|
| Unigene ID | Hs.440848 |
|---|---|
| Mm.22339 | |
| Rn.35561 |
| KEGG ID | hsa:7450 |
|---|---|
| mmu:22371 | |
| rno:116669 |
| Swiss-Prot ID | VWF_HUMAN |
|---|---|
| VWF_MOUSE |
| Ensembl ID | ENSG00000110799 |
|---|---|
| ENSP00000261405 | |
| ENST00000261405 | |
| ENSMUSG00000001930 | |
| ENSMUSP00000001995 | |
| ENSMUST00000001995 | |
| ENSMUSP00000107873 | |
| ENSMUST00000112254 |
| Homologene ID | 466 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98941 |
|---|
| RGD ID | 621759 |
|---|
| MedScan ID | 7450 |
|---|