Elsevier Inc. Serpinc1 ---| F9a Proc_act_diss pF13a F10a F5a F8a F9a vitamin K-dependent proteins, coagulation F7a F7 Proz ---- Serpina10 tenase complex extrinsic tenase complex Klkb1 --+> F12a F12a --+> Klkb1 protein C anticoagulant pathway Serpina10 ---| F10a Proc_act_diss ---| F5a Proc_act_diss ---| F8a F10 ---- TF/F7a complex extrinsic tenase complex --+> F10a F2a ---> protease mediated signaling pathway F10a ---> protease mediated signaling pathway prothrombinase complex --+> F2a F12 tenase complex ---> F10 F12a --+> F11a F12a ---> F11 F3 ---- F7a F11a ---> F9 F11a --+> F9a Vwf F8 F9a ---> F8 F7 --+> F7a F8 ---- Vwf F12 --+> F12a prothrombinase complex ---> F2 fibrin polymerization, cross-linking --+> fibrinolysis pathway Serping1 ---| F12a Serping1 ---| F11a TF/F7a complex TF/F7a complex --+> F9a F2a --+> fibrin pF13 --+> pF13a pKlkb1 Klkb1 Serping1 ---| Klkb1 F2a ---> fibrinogen F5 --+> F5a Tfpi ---| extrinsic tenase complex fibrinolysis pathway ---> fibrin pF13a --+> fibrin polymerization, cross-linking F10 F2 F5 tenase complex --+> F10a Serpinc1 ---| F2a Serpinc1 ---| F10a protease mediated signaling pathway F11 F9a --+> F8a F9 prothrombinase complex F2a pF13 fibrin fibrinogen fibrin polymerization, cross-linking vitamin K cycle pathway kallikrein-kinin cascade pathway F3 Proz Serpina10 Serpinc1 Tfpi Serping1 F12a F11a fibrinolysis pathway