| URN | urn:agi-llid:301 |
|---|---|
| Total Entities | 0 |
| Connectivity | 596 |
| Name | Anxa1 |
| Description | annexin A1 |
| Notes | Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Endocytosis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | structural molecule activity |
|---|---|
| receptor binding | |
| protein binding, bridging | |
| protein homodimerization activity | |
| phospholipid binding | |
| calcium-dependent phospholipid binding | |
| single-stranded RNA binding | |
| single-stranded DNA binding | |
| calcium ion binding | |
| phospholipase A2 inhibitor activity | |
| phospholipase inhibitor activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| mitochondrial membrane | |
| basolateral plasma membrane | |
| protein complex | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| cornified envelope | |
| nucleus | |
| cilium | |
| sarcolemma | |
| extracellular space |
| GO Biological Process | cell cycle |
|---|---|
| cellular component movement | |
| signal transduction | |
| regulation of cell proliferation | |
| cell surface receptor signaling pathway | |
| positive regulation of prostaglandin biosynthetic process | |
| negative regulation of protein secretion | |
| negative regulation of apoptotic process | |
| positive regulation of vesicle fusion | |
| positive regulation of apoptotic process | |
| positive regulation of neutrophil apoptotic process | |
| hepatocyte differentiation | |
| keratinocyte differentiation | |
| alpha-beta T cell differentiation | |
| gliogenesis | |
| insulin secretion | |
| peptide cross-linking | |
| cellular response to hydrogen peroxide | |
| cellular response to glucocorticoid stimulus | |
| neutrophil homeostasis | |
| response to drug | |
| response to organic cyclic compound | |
| response to hormone stimulus | |
| response to peptide hormone stimulus | |
| response to corticosteroid stimulus | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to interleukin-1 | |
| inflammatory response | |
| negative regulation of acute inflammatory response | |
| response to X-ray | |
| negative regulation of catalytic activity | |
| endocrine pancreas development | |
| neutrophil clearance | |
| estrous cycle phase | |
| arachidonic acid secretion |
| Pathway | TLR4/AP-1/EGR1/HIF1A Expression Targets |
|---|---|
| cyclooxygenase mediated pathway of arachidonic acid metabolism |
| Group | Endocytosis |
|---|---|
| cell cycle | |
| cellular component movement | |
| signal transduction | |
| regulation of cell proliferation | |
| cell surface receptor signaling pathway | |
| positive regulation of prostaglandin biosynthetic process | |
| negative regulation of protein secretion | |
| negative regulation of apoptotic process | |
| positive regulation of vesicle fusion | |
| positive regulation of apoptotic process | |
| positive regulation of neutrophil apoptotic process | |
| hepatocyte differentiation | |
| keratinocyte differentiation | |
| alpha-beta T cell differentiation | |
| gliogenesis | |
| insulin secretion | |
| peptide cross-linking | |
| cellular response to hydrogen peroxide | |
| cellular response to glucocorticoid stimulus | |
| neutrophil homeostasis | |
| response to drug | |
| response to organic cyclic compound | |
| response to hormone stimulus | |
| response to peptide hormone stimulus | |
| response to corticosteroid stimulus | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to interleukin-1 | |
| inflammatory response | |
| negative regulation of acute inflammatory response | |
| response to X-ray | |
| negative regulation of catalytic activity | |
| endocrine pancreas development | |
| neutrophil clearance | |
| estrous cycle phase | |
| arachidonic acid secretion | |
| structural molecule activity | |
| receptor binding | |
| protein binding, bridging | |
| protein homodimerization activity | |
| phospholipid binding | |
| calcium-dependent phospholipid binding | |
| single-stranded RNA binding | |
| single-stranded DNA binding | |
| calcium ion binding | |
| phospholipase A2 inhibitor activity | |
| phospholipase inhibitor activity | |
| membrane | |
| extracellular region | |
| mitochondrial membrane | |
| basolateral plasma membrane | |
| protein complex | |
| plasma membrane | |
| cell projection | |
| cytoplasm | |
| cornified envelope | |
| nucleus | |
| cilium | |
| sarcolemma | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 301 |
|---|
| Hugo ID | 533 |
|---|
| Human chromosome position | 9q21.13 |
|---|
| LocusLink ID | 301 |
|---|---|
| 16952 | |
| 25380 |
| Alias | ANX1 |
|---|---|
| LPC1 | |
| RP11-71A24.1 | |
| annexin A1 | |
| p35 | |
| annexin-1 | |
| calpactin-2 | |
| calpactin II | |
| lipocortin I | |
| chromobindin-9 | |
| annexin I (lipocortin I) | |
| phospholipase A2 inhibitory protein | |
| Anx-1 | |
| Lpc-1 | |
| Anx-A1 | |
| C430014K04Rik | |
| annexin I | |
| lipocortin 1 | |
| Annexin 1 (p35) (Lipocortin 1) | |
| LPC I | |
| OTTHUMP00000021474 | |
| OTTHUMP00000021475 | |
| p35 Lipocortin I | |
| p35 Lipocortin 1 | |
| Chromobindin 9 | |
| annexin 1 (lipocortin 1) | |
| ANX I | |
| ANXA I | |
| ANXA1 | |
| C430014K04 | |
| annexin 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 151690 |
|---|
| Unigene ID | Hs.494173 |
|---|---|
| Mm.248360 | |
| Rn.1792 |
| KEGG ID | hsa:301 |
|---|---|
| mmu:16952 | |
| rno:25380 |
| Swiss-Prot Accession | P04083 |
|---|---|
| Q5TZZ9 | |
| P10107 | |
| Q4FJV4 | |
| P07150 | |
| Q64664 |
| GO ID | 0005509 |
|---|---|
| 0005544 | |
| 0019834 | |
| 0005543 | |
| 0030674 | |
| 0042803 | |
| 0005102 | |
| 0003697 | |
| 0003727 | |
| 0005198 | |
| 0046632 | |
| 0050482 | |
| 0007049 | |
| 0007166 | |
| 0006928 | |
| 0071385 | |
| 0070301 | |
| 0031018 | |
| 0060206 | |
| 0042063 | |
| 0070365 | |
| 0006954 | |
| 0030073 | |
| 0030216 | |
| 0002674 | |
| 0043066 | |
| 0050709 | |
| 0097350 | |
| 0001780 | |
| 0018149 | |
| 0043065 | |
| 0031394 | |
| 0031340 | |
| 0042127 | |
| 0010165 | |
| 0042493 | |
| 0032355 | |
| 0070555 | |
| 0014070 | |
| 0043434 | |
| 0007165 | |
| 0016323 | |
| 0005929 | |
| 0001533 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0031966 | |
| 0005634 | |
| 0005886 | |
| 0043234 | |
| 0042383 | |
| 0004859 | |
| 0043086 | |
| 0033031 | |
| 0042995 | |
| 0016020 | |
| 0031960 | |
| 0051384 | |
| 0009725 | |
| 0006916 |
| PIR ID | A03080 |
|---|---|
| JT0303 | |
| S02181 |
| Swiss-Prot ID | ANXA1_HUMAN |
|---|---|
| ANXA1_RAT | |
| ANXA1_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Cell projection | |
| cilium | |
| Basolateral cell membrane | |
| Plasma membrane |
| IPI ID | IPI00218918 |
|---|---|
| IPI00231615 | |
| IPI00230395 |
| Mouse chromosome position | 19 18.0 cM |
|---|
| Rat chromosome position | 1q51 |
|---|
| Homologene ID | 563 |
|---|
| MGI ID | 96819 |
|---|
| RGD ID | 2118 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|