| URN | urn:agi-llid:7431 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1270 |
| Name | Vim |
| Description | vimentin |
| Notes | This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009] |
| Ariadne Ontology | Intermediate filament polymerization |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | structural molecule activity |
|---|---|
| scaffold protein binding | |
| protein C-terminus binding | |
| kinase binding | |
| protein kinase binding | |
| protein phosphatase 2A binding | |
| structural constituent of eye lens | |
| structural constituent of cytoskeleton |
| GO Cellular Component | nuclear matrix |
|---|---|
| intermediate filament | |
| type III intermediate filament | |
| plasma membrane | |
| cell projection | |
| cell leading edge | |
| cell body | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| peroxisome | |
| cytoskeleton | |
| intermediate filament cytoskeleton | |
| axon |
| GO Biological Process | virus-host interaction |
|---|---|
| cellular component movement | |
| intermediate filament-based process | |
| negative regulation of neuron projection development | |
| positive regulation of glial cell proliferation | |
| regulation of axonogenesis | |
| regulation of Schwann cell migration | |
| lens fiber cell development | |
| astrocyte development | |
| fat cell differentiation | |
| Bergmann glial cell differentiation | |
| muscle filament sliding | |
| cellular response to fibroblast growth factor stimulus | |
| apoptotic process | |
| intermediate filament organization | |
| cellular component disassembly involved in execution phase of apoptosis | |
| response to selenium ion | |
| response to zinc ion | |
| response to estradiol stimulus | |
| response to vitamin D | |
| response to radiation | |
| aging | |
| decidualization | |
| skeletal muscle tissue regeneration |
| Pathway | Intermediate Filament Polymerization |
|---|---|
| Canonical WNT Signaling Expression Targets | |
| BMP2-BMPR2 Expression Targets | |
| BMP4-BMPR2 Expression Targets | |
| BMP7-BMPR2/ACVR2 Expression Targets | |
| TDGF1-ACVR2B Expression Targets | |
| INHBA-ACVR2/BMPR Expression Targets | |
| WNT5A Expression Targets | |
| IL1B/NO Expression Targets | |
| EGF/CTNN Expression Targets | |
| cyclooxygenase mediated pathway of arachidonic acid metabolism |
| Group | Intermediate filament polymerization |
|---|---|
| virus-host interaction | |
| cellular component movement | |
| intermediate filament-based process | |
| negative regulation of neuron projection development | |
| positive regulation of glial cell proliferation | |
| regulation of axonogenesis | |
| regulation of Schwann cell migration | |
| lens fiber cell development | |
| astrocyte development | |
| fat cell differentiation | |
| Bergmann glial cell differentiation | |
| muscle filament sliding | |
| cellular response to fibroblast growth factor stimulus | |
| apoptotic process | |
| intermediate filament organization | |
| cellular component disassembly involved in execution phase of apoptosis | |
| response to selenium ion | |
| response to zinc ion | |
| response to estradiol stimulus | |
| response to vitamin D | |
| response to radiation | |
| aging | |
| decidualization | |
| skeletal muscle tissue regeneration | |
| structural molecule activity | |
| scaffold protein binding | |
| protein C-terminus binding | |
| kinase binding | |
| protein kinase binding | |
| protein phosphatase 2A binding | |
| structural constituent of eye lens | |
| structural constituent of cytoskeleton | |
| nuclear matrix | |
| intermediate filament | |
| type III intermediate filament | |
| plasma membrane | |
| cell projection | |
| cell leading edge | |
| cell body | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytosol | |
| peroxisome | |
| cytoskeleton | |
| intermediate filament cytoskeleton | |
| axon | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 7431 |
|---|
| Hugo ID | 12692 |
|---|
| Human chromosome position | 10p13 |
|---|
| LocusLink ID | 7431 |
|---|---|
| 22352 | |
| 81818 |
| Alias | RP11-124N14.1 |
|---|---|
| vimentin | |
| RP23-185P20.1 | |
| OTTHUMP00000019224 | |
| Vim | |
| OTTMUSP00000012058 | |
| MGC102095 | |
| FLJ36605 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 193060 |
|---|
| Unigene ID | Hs.455493 |
|---|---|
| Hs.691131 | |
| Mm.268000 | |
| Rn.2710 |
| KEGG ID | hsa:7431 |
|---|---|
| mmu:22352 | |
| rno:81818 |
| Swiss-Prot Accession | P08670 |
|---|---|
| P20152 | |
| Q5FWJ3 | |
| P31000 | |
| O08704 | |
| Q8CCH1 | |
| B0YJC2 | |
| D3DRU4 | |
| Q15867 | |
| Q15868 | |
| Q15869 | |
| Q548L2 | |
| Q6LER9 | |
| Q8N850 | |
| Q96ML2 | |
| Q9NTM3 |
| GO ID | 0008022 |
|---|---|
| 0019901 | |
| 0097110 | |
| 0005200 | |
| 0005212 | |
| 0060020 | |
| 0006915 | |
| 0014002 | |
| 0006921 | |
| 0006928 | |
| 0045109 | |
| 0070307 | |
| 0030049 | |
| 0010977 | |
| 0019048 | |
| 0030424 | |
| 0031252 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0005882 | |
| 0045111 | |
| 0005777 | |
| 0005886 | |
| 0019900 | |
| 0051721 | |
| 0005198 | |
| 0045103 | |
| 0060252 | |
| 1900147 | |
| 0050770 | |
| 0044297 | |
| 0042995 | |
| 0048471 | |
| 0045098 | |
| 0007568 | |
| 0044344 | |
| 0046697 | |
| 0045444 | |
| 0032355 | |
| 0009314 | |
| 0010269 | |
| 0033280 | |
| 0010043 | |
| 0043403 | |
| 0016363 |
| PIR ID | A43803 |
|---|---|
| S22119 | |
| S13115 |
| Swiss-Prot ID | VIME_MOUSE |
|---|---|
| VIME_RAT | |
| VIME_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus matrix |
| IPI ID | IPI00227299 |
|---|---|
| IPI00230941 | |
| IPI00418471 |
| Mouse chromosome position | 2 7.0 cM |
|---|
| Rat chromosome position | 17q12.3 |
|---|
| Homologene ID | 2538 |
|---|
| MGI ID | 98932 |
|---|
| RGD ID | 621646 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|