| URN | urn:agi-llid:5321 |
|---|---|
| Total Entities | 0 |
| Connectivity | 555 |
| Name | Pla2g4a |
| Description | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| Notes | This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Lipid degradation |
|---|---|
| PLA2 | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | calcium-dependent phospholipid binding |
|---|---|
| metal ion binding | |
| calcium ion binding | |
| hydrolase activity | |
| lysophospholipase activity | |
| phospholipase A2 activity | |
| calcium-dependent phospholipase A2 activity | |
| phospholipase activity |
| GO Cellular Component | endoplasmic reticulum membrane |
|---|---|
| mitochondrial inner membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| zymogen granule | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| regulation of cell proliferation | |
| positive regulation of prostaglandin biosynthetic process | |
| positive regulation of cell proliferation | |
| positive regulation of vesicle fusion | |
| positive regulation of apoptotic process | |
| platelet activation | |
| phosphatidylserine acyl-chain remodeling | |
| arachidonic acid metabolic process | |
| phosphatidylcholine acyl-chain remodeling | |
| phosphatidylethanolamine acyl-chain remodeling | |
| platelet activating factor biosynthetic process | |
| phospholipid metabolic process | |
| phospholipid catabolic process | |
| glycerophospholipid biosynthetic process | |
| phosphatidic acid biosynthetic process | |
| phosphatidylinositol acyl-chain remodeling | |
| phosphatidylglycerol acyl-chain remodeling | |
| cardiolipin acyl-chain remodeling | |
| cellular response to antibiotic | |
| response to organic substance | |
| response to hydrogen peroxide | |
| response to calcium ion | |
| response to lithium ion | |
| response to organic nitrogen | |
| response to methylmercury | |
| response to hormone stimulus | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| response to vitamin D | |
| response to heat | |
| positive regulation of inflammatory response | |
| positive regulation of fever generation | |
| positive regulation of bone mineralization | |
| aging | |
| decidualization | |
| ovulation from ovarian follicle | |
| blood coagulation | |
| luteolysis | |
| arachidonic acid secretion | |
| lipid metabolic process | |
| lipid catabolic process | |
| icosanoid biosynthetic process | |
| small molecule metabolic process | |
| icosanoid metabolic process | |
| surfactant homeostasis |
| Pathway | TLR1/2/6 Expression Targets |
|---|---|
| NGF/SMAD3/NF-kB Expression Targets | |
| IL15 Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| IL1B Expression Targets | |
| arachidonic acid metabolic pathway | |
| cyclooxygenase mediated pathway of arachidonic acid metabolism |
| Group | Lipid degradation |
|---|---|
| PLA2 | |
| metabolic process | |
| regulation of cell proliferation | |
| positive regulation of prostaglandin biosynthetic process | |
| positive regulation of cell proliferation | |
| positive regulation of vesicle fusion | |
| positive regulation of apoptotic process | |
| platelet activation | |
| phosphatidylserine acyl-chain remodeling | |
| arachidonic acid metabolic process | |
| phosphatidylcholine acyl-chain remodeling | |
| phosphatidylethanolamine acyl-chain remodeling | |
| platelet activating factor biosynthetic process | |
| phospholipid metabolic process | |
| phospholipid catabolic process | |
| glycerophospholipid biosynthetic process | |
| phosphatidic acid biosynthetic process | |
| phosphatidylinositol acyl-chain remodeling | |
| phosphatidylglycerol acyl-chain remodeling | |
| cardiolipin acyl-chain remodeling | |
| cellular response to antibiotic | |
| response to organic substance | |
| response to hydrogen peroxide | |
| response to calcium ion | |
| response to lithium ion | |
| response to organic nitrogen | |
| response to methylmercury | |
| response to hormone stimulus | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| response to vitamin D | |
| response to heat | |
| positive regulation of inflammatory response | |
| positive regulation of fever generation | |
| positive regulation of bone mineralization | |
| aging | |
| decidualization | |
| ovulation from ovarian follicle | |
| blood coagulation | |
| luteolysis | |
| arachidonic acid secretion | |
| lipid metabolic process | |
| lipid catabolic process | |
| icosanoid biosynthetic process | |
| small molecule metabolic process | |
| icosanoid metabolic process | |
| surfactant homeostasis | |
| calcium-dependent phospholipid binding | |
| metal ion binding | |
| calcium ion binding | |
| hydrolase activity | |
| lysophospholipase activity | |
| phospholipase A2 activity | |
| calcium-dependent phospholipase A2 activity | |
| phospholipase activity | |
| endoplasmic reticulum membrane | |
| mitochondrial inner membrane | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| endoplasmic reticulum | |
| Golgi apparatus | |
| zymogen granule | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5321 |
|---|
| Hugo ID | 9035 |
|---|
| Human chromosome position | 1q25 |
|---|
| LocusLink ID | 5321 |
|---|---|
| 18783 | |
| 24653 |
| Alias | PLA2G4 |
|---|---|
| cPLA2-alpha | |
| cytosolic phospholipase A2 | |
| cPLA2 | |
| lysophospholipase | |
| phospholipase A2 group IVA | |
| phosphatidylcholine 2-acylhydrolase | |
| calcium-dependent phospholipid-binding protein | |
| cPLA2alpha | |
| Type IV PLA2 | |
| cytosolic PLA2 | |
| phospholipase A2, group 4 | |
| Cytosolic phospholipase A2 (CPLA2) | |
| Pla2c | |
| phospholipase A2 cytosolic | |
| MGC126350 | |
| phospholipase A2, group IVA (cytosolic) | |
| phospholipase A2, group IV | |
| phosphatidase B | |
| OTTHUMP00000033543 | |
| Type IVA cytosolic phospholipase A2 | |
| OTTMUSP00000017675 | |
| phospholipase B | |
| PLA2G4A | |
| lysophospholipase A1 | |
| Type IVA cPLA2 | |
| phospholipase a2, group IVA | |
| Type IVA PLA2 | |
| phospholipase A2, group IVA (cytosolic, calcium-dependent) | |
| lysophosphatidylcholine hydrolase | |
| cytosolic phospholipase A2, group IVA | |
| cytosolic phospholipase A2a | |
| cytosolic phospholipase A2-alpha | |
| group IVA cPLA2 | |
| group IVA cytosolic phospholipase A2 | |
| lecithinase A | |
| lecithinase B | |
| lecitholipase | |
| LOC226493 | |
| lysolecithinase | |
| group IVA phospholipase A2 | |
| lysophosphatidase | |
| cPLA2a | |
| lysophopholipase L2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600522 |
|---|
| Unigene ID | Hs.497200 |
|---|---|
| Mm.4186 | |
| Rn.10162 |
| KEGG ID | hsa:5321 |
|---|---|
| mmu:18783 | |
| rno:24653 |
| Swiss-Prot Accession | P47712 |
|---|---|
| P47713 | |
| Q3UMQ1 | |
| Q6IRF5 | |
| P50393 | |
| B1AKG4 | |
| Q29R80 |
| EC Number | 3.1.1.5 |
|---|---|
| 3.1.1.4 |
| GO ID | 0005509 |
|---|---|
| 0047498 | |
| 0005544 | |
| 0016787 | |
| 0004622 | |
| 0004623 | |
| 0007568 | |
| 0019369 | |
| 0050482 | |
| 0007596 | |
| 0035965 | |
| 0071236 | |
| 0046697 | |
| 0046474 | |
| 0046456 | |
| 0006690 | |
| 0001554 | |
| 0001542 | |
| 0006654 | |
| 0036151 | |
| 0036152 | |
| 0036148 | |
| 0036149 | |
| 0036150 | |
| 0009395 | |
| 0006644 | |
| 0006663 | |
| 0030168 | |
| 0043065 | |
| 0030501 | |
| 0008284 | |
| 0031622 | |
| 0031394 | |
| 0031340 | |
| 0051592 | |
| 0051384 | |
| 0009408 | |
| 0042542 | |
| 0032496 | |
| 0051597 | |
| 0010243 | |
| 0033280 | |
| 0044281 | |
| 0043129 | |
| 0005794 | |
| 0005829 | |
| 0005789 | |
| 0005743 | |
| 0005634 | |
| 0048471 | |
| 0042588 | |
| 0046872 | |
| 0004620 | |
| 0016042 | |
| 0006629 | |
| 0008152 | |
| 0050729 | |
| 0042127 | |
| 0010033 | |
| 0005737 | |
| 0031410 | |
| 0005783 | |
| 0043231 | |
| 0009725 | |
| 0010226 |
| PIR ID | B39898 |
|---|---|
| A39329 |
| Swiss-Prot ID | PA24A_MOUSE |
|---|---|
| PA24A_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Cytoplasmic vesicle | |
| Plasma membrane |
| IPI ID | IPI00111169 |
|---|---|
| IPI00026108 |
| Mouse chromosome position | 1 76.0 cM |
|---|
| Rat chromosome position | 13q21 |
|---|
| Homologene ID | 32059 |
|---|
| MGI ID | 1195256 |
|---|
| RGD ID | 67366 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm |