| URN | urn:agi-llid:5743 |
|---|---|
| Total Entities | 0 |
| Connectivity | 5024 |
| Name | Ptgs2 |
| Description | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| Notes | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] |
| Ariadne Ontology | Prostaglandins, Thromboxane synthesis |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | lipid binding |
|---|---|
| enzyme binding | |
| protein homodimerization activity | |
| heme binding | |
| metal ion binding | |
| oxidoreductase activity | |
| prostaglandin-endoperoxide synthase activity | |
| peroxidase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| nuclear envelope | |
| endoplasmic reticulum lumen | |
| caveola | |
| protein complex | |
| cytoplasm | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| neuron projection |
| GO Biological Process | maintenance of blood-brain barrier |
|---|---|
| cellular component movement | |
| regulation of cell cycle | |
| negative regulation of cell cycle | |
| negative regulation of synaptic transmission, dopaminergic | |
| positive regulation of synaptic transmission, glutamatergic | |
| positive regulation of synaptic plasticity | |
| positive regulation of NF-kappaB import into nucleus | |
| regulation of cell proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of prostaglandin biosynthetic process | |
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| positive regulation of cell death | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of cell migration involved in sprouting angiogenesis | |
| positive regulation of brown fat cell differentiation | |
| positive regulation of apoptotic process | |
| keratinocyte differentiation | |
| brown fat cell differentiation | |
| xenobiotic metabolic process | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| cyclooxygenase pathway | |
| cellular response to ATP | |
| cellular response to hypoxia | |
| cellular response to mechanical stimulus | |
| cellular response to UV | |
| response to organic substance | |
| response to drug | |
| response to manganese ion | |
| response to lithium ion | |
| response to organic nitrogen | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to fructose stimulus | |
| response to vitamin D | |
| response to fatty acid | |
| response to tumor necrosis factor | |
| response to oxidative stress | |
| inflammatory response | |
| regulation of inflammatory response | |
| positive regulation of fever generation | |
| learning | |
| memory | |
| response to radiation | |
| negative regulation of smooth muscle contraction | |
| negative regulation of calcium ion transport | |
| positive regulation of transforming growth factor beta production | |
| positive regulation of platelet-derived growth factor production | |
| positive regulation of fibroblast growth factor production | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| decidualization | |
| angiogenesis | |
| anagen | |
| bone mineralization | |
| sensory perception of pain | |
| ovulation | |
| hair cycle | |
| embryo implantation | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| prostaglandin metabolic process | |
| regulation of blood pressure |
| Pathway | Omega-6-fatty acid metabolism |
|---|---|
| Cyclosporine-Induced Nephrotoxicity | |
| Clozapine-Induced Granulocytopenia | |
| Bextra-Induced Ischemic Disease | |
| ROS and RNS in Regulation of Vasoconstriction and Vasodilation | |
| ROS in Triggering Vascular Inflammation | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| BMP2-BMPR2 Expression Targets | |
| WNT1 Expression Targets | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| TLR3 Expression Targets | |
| FASLG Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| DLL1 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/STAT Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| CD40LG/STAT Expression Targets | |
| ICAM1 Expression Targets | |
| Fibronectin Expression Targets | |
| IL13 Expression Targets | |
| IL6 Expression Targets | |
| IL2 Expression Targets | |
| IL4 Expression Targets | |
| LIF Expression Targets | |
| CTF1 Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| CSF3 Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| CNTF Expression Targets | |
| IFNG-IFNR Expression Targets | |
| OSM-OSMR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| CCL2 Expression Targets | |
| CCL5 Expression Targets | |
| IL8 Expression Targets | |
| CXCL12 Expression Targets | |
| SST Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| GNRH2 Expression Targets | |
| S100B Expression Targets | |
| HMGB1 Expression Targets | |
| AREG/STAT Expression Targets | |
| AREG/AP-1 Expression Targets | |
| AREG/NFATC Expression Target | |
| EGF/HIF1A Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/STAT Expression Targets | |
| EREG/AP-1/ATF Expression Targets | |
| HBEGF/STAT Expression Targets | |
| HBEGF/AP-1/ATF Expression Targets | |
| NRG1/Catenin Expression Targets | |
| NRG1/STAT Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/EP300/ETS/ETV/SP1 Expression Targets | |
| TGFA/CTNNB/CTNND Expression Targets | |
| TGFA/STAT Expression Targets | |
| TGFA/HIF1A Expression Targets | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| TGFA/TP53 Expression Targets | |
| FGF10/STAT Expression Targets | |
| KITLG/STAT Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFA/NFATC Expression Targets | |
| VEGFA/ATF/CREB/ELK-SRF Expression Targets | |
| IGF2/HIF1A/MYC Expression Targets | |
| IGF2/STAT Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF7/AP-1/CREB/CREBBP/MYC Expression Targets | |
| FGF10/AP-1/CREB/CREBBP/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| Thromboxane A2 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| OXT Expression Targets | |
| Serotonin/Gq Expression Targets | |
| Epinephrine/Gq Expression Targets | |
| Adenosine Expression Targets | |
| Prostaglandin F Expression Targets | |
| Glutamate/Gq Expression Targets | |
| AVP/Gq -> STAT Expression Targets | |
| AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| GNRH1 Expression Targets | |
| Morphine Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| NTS Expression Targets | |
| GAST Expression Targets | |
| S1P Expression Targets | |
| TAC1 Expression Targets | |
| PGE1 Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| Noradrenaline/Gs Expression Targets | |
| Dopamine/Gs Expression Targets | |
| AVP/Gs -> STAT Expression Targets | |
| FSHR Expression Targets | |
| AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| Serotonin/Gs Expression Targets | |
| Noreadrenaline/Gq Expression Targets | |
| CXCL1 Expression Targets | |
| CXCL5 Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| ADCYAP1 Expression Targets | |
| CD80/STAT Expression Targets | |
| CD80/NF-kB Expression Targets | |
| CD80/NFATC Expression Targets | |
| CD80/AP-1 Expression Targets | |
| CD80/ATF/CREB/CREBBP Expression Targets | |
| TCR/STAT Expression Targets | |
| TCR/AP-1 Expression Targets | |
| AGT/TP53 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| IGF1/STAT Expression Targets | |
| VEGFA/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1A Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| NOTCH Expression Targets | |
| TNF/NF-kB Expression Targets | |
| WNT5A Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| IL1B/NO Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TCR/NFAT Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| VEGFA/AP-1/CREBBP/MYC Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| paracetamol drug pathway | |
| prostanoid biosynthetic pathway | |
| cyclooxygenase mediated pathway of arachidonic acid metabolism |
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| maintenance of blood-brain barrier | |
| cellular component movement | |
| regulation of cell cycle | |
| negative regulation of cell cycle | |
| negative regulation of synaptic transmission, dopaminergic | |
| positive regulation of synaptic transmission, glutamatergic | |
| positive regulation of synaptic plasticity | |
| positive regulation of NF-kappaB import into nucleus | |
| regulation of cell proliferation | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of prostaglandin biosynthetic process | |
| negative regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| positive regulation of cell death | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of cell migration involved in sprouting angiogenesis | |
| positive regulation of brown fat cell differentiation | |
| positive regulation of apoptotic process | |
| keratinocyte differentiation | |
| brown fat cell differentiation | |
| xenobiotic metabolic process | |
| fatty acid biosynthetic process | |
| fatty acid metabolic process | |
| cyclooxygenase pathway | |
| cellular response to ATP | |
| cellular response to hypoxia | |
| cellular response to mechanical stimulus | |
| cellular response to UV | |
| response to organic substance | |
| response to drug | |
| response to manganese ion | |
| response to lithium ion | |
| response to organic nitrogen | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| response to estradiol stimulus | |
| response to fructose stimulus | |
| response to vitamin D | |
| response to fatty acid | |
| response to tumor necrosis factor | |
| response to oxidative stress | |
| inflammatory response | |
| regulation of inflammatory response | |
| positive regulation of fever generation | |
| learning | |
| memory | |
| response to radiation | |
| negative regulation of smooth muscle contraction | |
| negative regulation of calcium ion transport | |
| positive regulation of transforming growth factor beta production | |
| positive regulation of platelet-derived growth factor production | |
| positive regulation of fibroblast growth factor production | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of vasoconstriction | |
| positive regulation of smooth muscle contraction | |
| decidualization | |
| angiogenesis | |
| anagen | |
| bone mineralization | |
| sensory perception of pain | |
| ovulation | |
| hair cycle | |
| embryo implantation | |
| lipid metabolic process | |
| prostaglandin biosynthetic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| prostaglandin metabolic process | |
| regulation of blood pressure | |
| lipid binding | |
| enzyme binding | |
| protein homodimerization activity | |
| heme binding | |
| metal ion binding | |
| oxidoreductase activity | |
| prostaglandin-endoperoxide synthase activity | |
| peroxidase activity | |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | |
| membrane | |
| endoplasmic reticulum membrane | |
| nuclear envelope | |
| endoplasmic reticulum lumen | |
| caveola | |
| protein complex | |
| cytoplasm | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| neuron projection | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5743 |
|---|
| Hugo ID | 9605 |
|---|
| Human chromosome position | 1q25.2-q25.3 |
|---|
| LocusLink ID | 5743 |
|---|---|
| 19225 | |
| 29527 |
| Alias | COX2 |
|---|---|
| COX-2 | |
| PHS-2 | |
| PGG/HS | |
| PGHS-2 | |
| hCox-2 | |
| GRIPGHS | |
| prostaglandin G/H synthase 2 | |
| PHS II | |
| PGH synthase 2 | |
| cyclooxygenase 2b | |
| prostaglandin H2 synthase 2 | |
| Pghs2 | |
| TIS10 | |
| PES-2 | |
| cyclooxygenase 2 | |
| cyclooxygenase-2 | |
| glucocorticoid-regulated inflammatory cyclooxygenase | |
| macrophage activation-associated marker protein P71/73 | |
| prostaglandin G/H synthetase and cyclooxygenase II | |
| prostaglandin G/H synthetase and cyclooxygenase 2 | |
| Prostaglandin G/H synthetase 2 | |
| prostaglandin G/H synthetase | |
| prostaglandin G/H synthase and cyclooxygenase II | |
| prostaglandin G/H synthase and cyclooxygenase 2 | |
| prostaglandin G/H synthase | |
| Prostaglandin H2 synthase II | |
| Prostaglandin H2 synthetase 2 | |
| Prostaglandin H2 synthetase II | |
| prostaglandin-endoperoxide synthase 2 | |
| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | |
| prostaglandin-endoperoxide synthase II | |
| prostaglandin-endoperoxide synthetase 2 | |
| prostaglandin-endoperoxide synthetase 2 (prostaglandin G/H synthetase and cyclooxygenase) | |
| prostaglandin-endoperoxide synthetase II | |
| TIS10/PGS-2 | |
| PTGS2 | |
| 1DDX_A | |
| 1DDX_As | |
| 1DDX_B | |
| 1DDX_Bs | |
| PGH synthase II | |
| cyclooxygenase II | |
| PGS-2/TIS10 | |
| cyclo-oxygenase-2 | |
| PGH synthetase II | |
| hCox II | |
| PGHS II | |
| PGH synthetase 2 | |
| OTTHUMP00000033524 | |
| hCox IIs | |
| PGHS IIs |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600262 |
|---|
| Unigene ID | Hs.196384 |
|---|---|
| Mm.292547 | |
| Rn.44369 |
| KEGG ID | hsa:5743 |
|---|---|
| mmu:19225 | |
| rno:29527 |
| Swiss-Prot Accession | P35354 |
|---|---|
| Q05769 | |
| P35355 | |
| Q64379 | |
| Q925V4 | |
| Q543K3 | |
| A8K802 | |
| Q16876 |
| EC Number | 1.14.99.1 |
|---|
| GO ID | 0019899 |
|---|---|
| 0020037 | |
| 0008289 | |
| 0046872 | |
| 0016702 | |
| 0004601 | |
| 0004666 | |
| 0042803 | |
| 0042640 | |
| 0030282 | |
| 0050873 | |
| 0006928 | |
| 0071456 | |
| 0019371 | |
| 0046697 | |
| 0007566 | |
| 0006954 | |
| 0007613 | |
| 0051926 | |
| 0008285 | |
| 0032227 | |
| 0030728 | |
| 0043065 | |
| 0090336 | |
| 0090050 | |
| 0031622 | |
| 0090271 | |
| 0045429 | |
| 0090362 | |
| 0031394 | |
| 0048661 | |
| 0045987 | |
| 0031915 | |
| 0051968 | |
| 0071636 | |
| 0045907 | |
| 0010575 | |
| 0001516 | |
| 0006693 | |
| 0008217 | |
| 0051726 | |
| 0050727 | |
| 0034097 | |
| 0042493 | |
| 0032355 | |
| 0009750 | |
| 0051384 | |
| 0032496 | |
| 0010042 | |
| 0014070 | |
| 0010243 | |
| 0006979 | |
| 0033280 | |
| 0044281 | |
| 0006805 | |
| 0005901 | |
| 0005737 | |
| 0005788 | |
| 0005789 | |
| 0043005 | |
| 0005634 | |
| 0043234 | |
| 0016491 | |
| 0001525 | |
| 0006633 | |
| 0006631 | |
| 0030216 | |
| 0007612 | |
| 0006629 | |
| 0035633 | |
| 0045786 | |
| 0045986 | |
| 0055114 | |
| 0042346 | |
| 0010942 | |
| 0008284 | |
| 0042127 | |
| 0019233 | |
| 0005783 | |
| 0043231 | |
| 0016020 | |
| 0071318 | |
| 0034644 | |
| 0071260 | |
| 0042633 | |
| 0070542 | |
| 0010226 | |
| 0010033 | |
| 0009314 | |
| 0034612 | |
| 0005635 |
| PIR ID | JC2030 |
|---|---|
| A49010 | |
| A46150 |
| Swiss-Prot ID | PGH2_RAT |
|---|---|
| PGH2_MOUSE | |
| PGH2_HUMAN |
| Cell Localization | Microsome membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Plasma membrane |
| IPI ID | IPI00197645 |
|---|---|
| IPI00308785 | |
| IPI00018109 |
| Mouse chromosome position | 1 76.2 cM |
|---|
| Rat chromosome position | 13q21 |
|---|
| Homologene ID | 31000 |
|---|
| MGI ID | 97798 |
|---|
| RGD ID | 620349 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|