| URN | urn:agi-llid:8569 |
|---|---|
| Total Entities | 0 |
| Connectivity | 127 |
| Name | Mknk1 |
| Description | MAP kinase interacting serine/threonine kinase 1 |
| Notes | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
| Ariadne Ontology | MNK1-2 |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity |
| GO Cellular Component | cytosol |
|---|---|
| nucleus |
| GO Biological Process | intracellular protein kinase cascade |
|---|---|
| fibroblast growth factor receptor signaling pathway | |
| regulation of translation | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| response to stress |
| Pathway | ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy |
|---|---|
| cyclooxygenase mediated pathway of arachidonic acid metabolism |
| Group | MNK1-2 |
|---|---|
| intracellular protein kinase cascade | |
| fibroblast growth factor receptor signaling pathway | |
| regulation of translation | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| response to stress | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| cytosol | |
| nucleus |
| MedScan ID | 8569 |
|---|
| Hugo ID | 7110 |
|---|
| Human chromosome position | 1p33 |
|---|
| LocusLink ID | 8569 |
|---|---|
| 17346 | |
| 500526 |
| Alias | MNK1 |
|---|---|
| RP11-49P4.3 | |
| MAP kinase-interacting serine/threonine-protein kinase 1 | |
| MAPK signal-integrating kinase 1 | |
| MAP kinase signal-integrating kinase 1 | |
| 2410048M24Rik | |
| RP23-374N19.2 | |
| Mitogen-activated protein kinase MAPK-interacting kinase 1 | |
| MGC112775 | |
| Mknk I | |
| MAPK interactive kinase I | |
| MNK I | |
| OTTHUMP00000009674 | |
| OTTHUMP00000009675 | |
| OTTMUSP00000009040 | |
| MAPK interactive kinase 1 | |
| OTTHUMP00000009676 | |
| MAP kinase interacting kinase 1 | |
| MAPK interacting kinase I | |
| Mknk1 | |
| 2410048M24 | |
| 2410048M24Rik(2) | |
| MAP kinase interacting kinase I | |
| MAP kinase interacting serine/threonine kinase 1 | |
| MAP kinase-interactive serine/threonine kinase I | |
| MAP kinase interactive kinase I | |
| MAPK interacting kinase 1 | |
| MAP kinase-interacting serine/threonine kinase I | |
| MAP kinase-interactive serine/threonine kinase 1 | |
| MAP kinase interactive kinase 1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606724 |
|---|
| Unigene ID | Hs.371594 |
|---|---|
| Mm.209327 | |
| Rn.230218 |
| KEGG ID | hsa:8569 |
|---|---|
| mmu:17346 | |
| rno:500526 |
| Swiss-Prot Accession | Q9BUB5 |
|---|---|
| A8K341 | |
| A2A8W8 | |
| O08605 | |
| Q4G050 | |
| D3DQ20 | |
| D3DQ21 | |
| O00312 | |
| Q5TC06 | |
| Q5TC07 | |
| Q6V0N6 |
| EC Number | 2.7.11.1 |
|---|
| GO ID | 0005524 |
|---|---|
| 0004674 | |
| 0008543 | |
| 0007243 | |
| 0018105 | |
| 0006468 | |
| 0006417 | |
| 0005829 | |
| 0005634 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0016310 | |
| 0006950 |
| Swiss-Prot ID | MKNK1_HUMAN |
|---|---|
| MKNK1_RAT | |
| MKNK1_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00187091 |
|---|---|
| IPI00304048 | |
| IPI00412417 | |
| IPI00566958 | |
| IPI00114849 |
| Mouse chromosome position | 4 |
|---|
| Rat chromosome position | 5q36 |
|---|
| Homologene ID | 37838 |
|---|
| MGI ID | 894316 |
|---|
| RGD ID | 1559603 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|