Elsevier Inc. PGG2 ---> PGH2 Ptgs2 Mknk1 --+> Pla2g4a Mknk1 P-Ser indomethacin diclonefac meloxicam celecoxib paracetamol Pla2g4a ---- Vim Vim --+> Pla2g4a Pla2g4a Vim Ca2+ phospholipid hydrolysis Ca2+ ---- Pla2g4a Anxa1 ---- Pla2g4a Anxa1 ---| Pla2g4a Mknk1 ---> Pla2g4a paracetamol ---| Ptgs1 paracetamol ---| Ptgs2 Anxa1 lysophospholipid arachidonic acid PGG2 PGH2 arachidonic acid ---> PGG2 prostanoid biosynthetic pathway ---> various responses elicited by signaling via prostanoids NSAIDs Ptgs1 selective Cox-2 inhibitors prostanoid biosynthetic pathway paracetamol ---| prostanoid biosynthetic pathway paracetamol drug pathway celecoxib ---| Ptgs2 indomethacin ---| Ptgs1 diclonefac ---| Ptgs1 various responses elicited by signaling via prostanoids phospholipids phospholipids ---> arachidonic acid phospholipids ---> lysophospholipid PGH2 --+> prostanoid biosynthetic pathway meloxicam ---| Ptgs2