| Name | G6pd |
|---|---|
| Description | glucose-6-phosphate dehydrogenase |
| Notes | This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. |
| Owner | Public |
| URN | urn:agi-llid:2539 |
| Connectivity | 629 |
| LocusLink ID | 2539 |
|---|---|
| 14381 | |
| 24377 |
| OMIM ID | 305900 |
|---|
| GO ID | 0005488 |
|---|---|
| 0004345 | |
| 0016491 | |
| 0005975 | |
| 0006010 | |
| 0006006 | |
| 0008152 | |
| 0006098 | |
| 0005575 | |
| 0005737 | |
| 0003824 | |
| 0042803 | |
| 0006741 | |
| 0001998 | |
| 0001816 | |
| 0048821 | |
| 0006749 | |
| 0032613 | |
| 0032615 | |
| 0019322 | |
| 0040014 | |
| 0006979 | |
| 0002033 | |
| 0050661 | |
| 0005536 | |
| 0005529 | |
| 0051156 | |
| 0009051 | |
| 0045767 | |
| 0005829 | |
| 0005792 | |
| 0005634 | |
| 0005625 |
| Hugo ID | 4057 |
|---|
| Human chromosome position | Xq28 |
|---|
| Unigene ID | Hs.461047 |
|---|---|
| Hs.684904 | |
| Mm.27210 | |
| Rn.11040 |
| KEGG ID | hsa:2539 |
|---|---|
| mmu:14381 | |
| rno:24377 |
| Alias | G6PD1 |
|---|---|
| glucose-6-phosphate dehydrogenase | |
| glucose-6-phosphate 1-dehydrogenase | |
| glucose-6-phosphate dehydrogenase, G6PD | |
| G28A | |
| G6pd | |
| Gpdx | |
| RP23-436K3.17 | |
| glucose-6-phosphate dehydrogenase X-linked | |
| G6pdx | |
| G6pdx-ps1 | |
| glucose-6-phosphate dehydrogenase 2 | |
| Glucose-6-phosphate dehydrogenase, autosomal | |
| 6-phosphoglucose dehydrogenase | |
| Entner-Doudoroff enzyme | |
| NADP-dependent glucose 6-phosphate dehydrogenase | |
| Zwischenferment | |
| glucose-6-phosphate dehydrogenase X-linked, pseudogene | |
| NADP-glucose-6-phosphate dehydrogenase | |
| glucose-6-phosphate dehydrogenase II | |
| G6pd2 | |
| G6PD I | |
| NADP-glucose-6-phosphate dehydrogenases | |
| 6-phosphoglucose dehydrogenases | |
| D-glucose 6-phosphate dehydrogenases | |
| NADP-dependent glucose 6-phosphate dehydrogenases | |
| G-6-PDHs | |
| glucose-6-phosphate dehydrogenase X-linked, pseudogene I | |
| G-6-PDH | |
| glucose-6-phosphate dehydrogenase X-linked, pseudogene 1 | |
| G6pdx-ps I | |
| D-glucose 6-phosphate dehydrogenase | |
| G(28)A | |
| G28-a | |
| G 28A | |
| G-28a |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | X 30.02 cM |
|---|
| Rat chromosome position | Xq37 |
|---|
| Cell Localization | Cytoplasm |
|---|
| Homologene ID | 37906 |
|---|
| Pathway | pentose phosphate pathway |
|---|
| MGI ID | 105979 |
|---|
| Ariadne Ontology | Pentose-phosphate shunt |
|---|
| RGD ID | 2645 |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| binding | |
| sugar binding | |
| glucose binding | |
| NADP binding | |
| protein homodimerization activity | |
| oxidoreductase activity | |
| glucose-6-phosphate dehydrogenase activity |
| GO Cellular Component | cellular_component |
|---|---|
| soluble fraction | |
| microsome | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| regulation of anti-apoptosis | |
| regulation of multicellular organism growth | |
| erythrocyte development | |
| vasodilation by angiotensin involved in regulation of systemic arterial blood pressure | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| pentose biosynthetic process | |
| pentose-phosphate shunt | |
| pentose-phosphate shunt, oxidative branch | |
| glucose metabolic process | |
| glucose 6-phosphate metabolic process | |
| glucose 6-phosphate utilization | |
| NADP biosynthetic process | |
| glutathione metabolic process | |
| carbohydrate metabolic process | |
| cytokine production | |
| interleukin-12 production | |
| interleukin-10 production | |
| response to oxidative stress |
| Group | cellular_component |
|---|---|
| soluble fraction | |
| microsome | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| catalytic activity | |
| binding | |
| sugar binding | |
| glucose binding | |
| NADP binding | |
| protein homodimerization activity | |
| oxidoreductase activity | |
| glucose-6-phosphate dehydrogenase activity | |
| metabolic process | |
| regulation of anti-apoptosis | |
| regulation of multicellular organism growth | |
| erythrocyte development | |
| vasodilation by angiotensin involved in regulation of systemic arterial blood pressure | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| pentose biosynthetic process | |
| pentose-phosphate shunt | |
| pentose-phosphate shunt, oxidative branch | |
| glucose metabolic process | |
| glucose 6-phosphate metabolic process | |
| glucose 6-phosphate utilization | |
| NADP biosynthetic process | |
| glutathione metabolic process | |
| carbohydrate metabolic process | |
| cytokine production | |
| interleukin-12 production | |
| interleukin-10 production | |
| response to oxidative stress | |
| Pentose-phosphate shunt |