| URN | urn:agi-llid:39 |
|---|---|
| Total Entities | 0 |
| Connectivity | 95 |
| Name | Acat2 |
| Description | acetyl-Coenzyme A acetyltransferase 2 |
| Notes | The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. |
| Ariadne Ontology | Branched amino acid metabolism |
|---|---|
| Aromatic amino acid metabolism | |
| Asp-Lys-Thr-Met-Cys metabolsm | |
| Fatty acid oxidation | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | acetyl-CoA C-acetyltransferase activity |
|---|
| GO Cellular Component | nucleolus |
|---|---|
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | cellular response to nutrient |
|---|---|
| ketone body catabolic process | |
| cellular response to fatty acid | |
| brain development | |
| liver development | |
| lipid metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| ketone bodies metabolic pathway | |
| ketone bodies metabolic pathway | |
| ketone bodies metabolic pathway | |
| cholesterol biosynthetic pathway |
| Group | Branched amino acid metabolism |
|---|---|
| Aromatic amino acid metabolism | |
| Asp-Lys-Thr-Met-Cys metabolsm | |
| Fatty acid oxidation | |
| cellular response to nutrient | |
| ketone body catabolic process | |
| cellular response to fatty acid | |
| brain development | |
| liver development | |
| lipid metabolic process | |
| acetyl-CoA C-acetyltransferase activity | |
| nucleolus | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 39 |
|---|
| Hugo ID | 94 |
|---|
| Human chromosome position | 6q25.3 |
|---|
| LocusLink ID | 39 |
|---|---|
| 308100 | |
| 110460 | |
| 224530 |
| Alias | acetyl-CoA acetyltransferase, cytosolic |
|---|---|
| acetoacetyl Coenzyme A thiolase | |
| cytosolic acetoacetyl-CoA thiolase | |
| acetyl-CoA transferase-like protein | |
| Acat2 | |
| Ab2-076 | |
| acetyl-Coenzyme A acetyltransferase 2 | |
| ACTL | |
| AW742799 | |
| Tcp-1x | |
| Tcp1-rs1 | |
| Tcp1-rs I | |
| t-complex protein 1, related sequence 1 | |
| OTTHUMP00000017527 | |
| MGC95138 | |
| Cytosolic acetoacetyl-coenzyme A thiolase | |
| Tcp-1xs | |
| acetyl-Coenzyme A acetyltransferase 3 | |
| Acat3 | |
| acetyl CoA transferase-like | |
| acetyl-CoA acetyltransferase 2 | |
| acetyl-Coenzyme A acetyltransferase II | |
| acetyl-Coenzyme A acetyltransferase III | |
| acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| OMIM ID | 100678 |
|---|---|
| 614055 |
| Unigene ID | Hs.571037 |
|---|---|
| Rn.203063 | |
| Mm.439711 | |
| Mm.229342 |
| KEGG ID | hsa:39 |
|---|---|
| rno:308100 | |
| mmu:110460 | |
| mmu:224530 |
| Swiss-Prot Accession | Q9BWD1 |
|---|---|
| Q5XI22 | |
| E1P5B1 | |
| Q16146 | |
| Q5TCL7 | |
| Q8TDM4 | |
| Q59GW6 | |
| Q8CAY6 | |
| Q80X81 | |
| Q8R4V3 | |
| Q7TP61 | |
| Q3TJY7 | |
| Q62292 | |
| Q96EB7 | |
| Q99K88 | |
| Q9CYV2 |
| EC Number | 2.3.1.9 |
|---|
| GO ID | 0003985 |
|---|---|
| 0006629 | |
| 0005737 | |
| 0005739 | |
| 0005730 | |
| 0005634 | |
| 0007420 | |
| 0071398 | |
| 0031670 | |
| 0046952 | |
| 0001889 | |
| 0005829 | |
| 0008415 | |
| 0016740 | |
| 0008152 | |
| 0003824 | |
| 0016747 | |
| 0071445 | |
| 0005515 | |
| 0003674 | |
| 0008150 | |
| 0005575 |
| PIR ID | JC2378 |
|---|---|
| A53174 |
| Swiss-Prot ID | THIC_HUMAN |
|---|---|
| THIC_RAT | |
| THIC_MOUSE | |
| Q80X81_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondria |
| IPI ID | IPI01014863 |
|---|---|
| IPI00480766 | |
| IPI00228253 | |
| IPI00291419 | |
| IPI00776358 | |
| IPI00330685 | |
| IPI00881591 | |
| IPI00880627 | |
| IPI00382233 |
| Mouse chromosome position | 17 7.55 cM |
|---|
| Rat chromosome position | 1q11 |
|---|
| Homologene ID | 55855 |
|---|
| MGI ID | 87871 |
|---|---|
| 109182 |
| RGD ID | 1359366 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|---|
| Mitochondria |