| URN | urn:agi-llid:3156 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1310 |
| Name | Hmgcr |
| Description | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| Notes | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein homodimerization activity |
|---|---|
| NADP binding | |
| NADPH binding | |
| coenzyme binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
| hydroxymethylglutaryl-CoA reductase activity | |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| peroxisomal membrane | |
| integral to membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | positive regulation of ERK1 and ERK2 cascade |
|---|---|
| positive regulation of stress-activated MAPK cascade | |
| negative regulation of MAP kinase activity | |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus | |
| negative regulation of apoptotic process | |
| negative regulation of striated muscle cell apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of cardiac muscle cell apoptotic process | |
| myoblast differentiation | |
| cellular lipid metabolic process | |
| coenzyme A metabolic process | |
| farnesyl diphosphate biosynthetic process, mevalonate pathway | |
| isoprenoid biosynthetic process | |
| ubiquinone metabolic process | |
| response to nutrient | |
| response to ethanol | |
| negative regulation of wound healing | |
| visual learning | |
| negative regulation of vasodilation | |
| positive regulation of skeletal muscle tissue development | |
| aging | |
| embryo development | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| protein tetramerization |
| Pathway | GH1-GHR/STAT Expression Targets |
|---|---|
| GH1-PRLR Expression Targets | |
| NRG1/Catenin Expression Targets | |
| NRG1/STAT Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/EP300/ETS/ETV/SP1 Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| cholesterol biosynthetic pathway | |
| statin pharmacodynamics pathway | |
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of stress-activated MAPK cascade | |
| negative regulation of MAP kinase activity | |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus | |
| negative regulation of apoptotic process | |
| negative regulation of striated muscle cell apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of cardiac muscle cell apoptotic process | |
| myoblast differentiation | |
| cellular lipid metabolic process | |
| coenzyme A metabolic process | |
| farnesyl diphosphate biosynthetic process, mevalonate pathway | |
| isoprenoid biosynthetic process | |
| ubiquinone metabolic process | |
| response to nutrient | |
| response to ethanol | |
| negative regulation of wound healing | |
| visual learning | |
| negative regulation of vasodilation | |
| positive regulation of skeletal muscle tissue development | |
| aging | |
| embryo development | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| protein tetramerization | |
| protein homodimerization activity | |
| NADP binding | |
| NADPH binding | |
| coenzyme binding | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
| hydroxymethylglutaryl-CoA reductase activity | |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| peroxisomal membrane | |
| integral to membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3156 |
|---|
| Hugo ID | 5006 |
|---|
| Human chromosome position | 5q13.3-q14 |
|---|
| LocusLink ID | 3156 |
|---|---|
| 15357 | |
| 25675 |
| Alias | LDLCQ3 |
|---|---|
| 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | |
| HMG-CoA reductase | |
| hydroxymethylglutaryl-CoA reductase | |
| 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) | |
| Red | |
| HMG-CoAR | |
| 3-hydroxy-3-methylglutaryl-CoA reductase | |
| 3H3M | |
| NADP(H)-hydroxymethylglutaryl-CoA reductase | |
| hydroxymethyl glutaryl CoA reductase | |
| hydroxymethyl glutaryl coenzyme A reductase | |
| hydroxymethylglutaryl CoA reductase (NAD(P)H) | |
| hydroxymethylglutaryl CoA reductase (NADP(H)) | |
| hydroxymethylglutaryl CoA reductase (NADPH) | |
| hydroxymethylglutaryl coenzyme A reductase | |
| hydroxymethylglutaryl-CoA (HMG-CoA) reductase | |
| hydroxymethylglutaryl-CoA reductase (NAD(P)H2) | |
| hydroxymethylglutaryl-CoA reductase (NADP(H)2) | |
| hydroxymethylglutaryl-CoA reductase (NADPH2) | |
| hydroxymethyl coenzyme A reductase | |
| MGC103269 | |
| NAD(P)H-hydroxymethylglutaryl-CoA reductase | |
| S-3-hydroxy-3-methylglutaryl-CoA reductase | |
| LOC218474 | |
| hydroxymethyl coenzyme A (HMG-CoA) reductase | |
| 3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase | |
| NADPH-hydroxymethylglutaryl-CoA reductase | |
| beta-hydroxy-beta-methylglutaryl coenzyme A reductase | |
| Dihydroxymethylglutaryl-CoA reductase (NAD(P)H) | |
| Dihydroxymethylglutaryl-CoA reductase (NAD(P)H) phosphate | |
| Dihydroxymethylglutaryl-CoA reductase (NADP(H)) | |
| Dihydroxymethylglutaryl-CoA reductase (NADPH) | |
| Dihydroxymethylglutaryl-CoA reductase (NADPH) phosphate | |
| HMGCoA reductase-mevalonate:NADP-oxidoreductase | |
| HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA) | |
| HMGCR | |
| hydroxymethyl CoA reductase | |
| Dihydroxymethylglutaryl-CoA reductase (NADP(H)) phosphate | |
| HMG-CoA reductase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 142910 |
|---|
| Unigene ID | Hs.628096 |
|---|---|
| Hs.643495 | |
| Mm.316652 | |
| Rn.9437 | |
| Mm.479532 | |
| Hs.698445 | |
| Hs.713530 | |
| Mm.475623 | |
| Hs.699171 |
| KEGG ID | hsa:3156 |
|---|---|
| mmu:15357 | |
| rno:25675 |
| Swiss-Prot Accession | P04035 |
|---|---|
| Q01237 | |
| Q8BV96 | |
| P51639 | |
| G3X8U5 | |
| Q5U4I2 | |
| Q8N190 | |
| Q64601 | |
| Q6P2A6 | |
| Q61671 | |
| Q6PB59 |
| EC Number | 1.1.1.34 |
|---|---|
| 1.1.1.88 |
| GO ID | 0070402 |
|---|---|
| 0050662 | |
| 0004420 | |
| 0042282 | |
| 0042803 | |
| 0007568 | |
| 0044255 | |
| 0006695 | |
| 0015936 | |
| 0009790 | |
| 0008299 | |
| 0043407 | |
| 0048643 | |
| 0051262 | |
| 0007584 | |
| 0044281 | |
| 0008542 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0005778 | |
| 0050661 | |
| 0016491 | |
| 0016616 | |
| 0008203 | |
| 0006629 | |
| 0043066 | |
| 0061179 | |
| 0010664 | |
| 0045908 | |
| 0061045 | |
| 0055114 | |
| 0070374 | |
| 0010666 | |
| 0008284 | |
| 0048661 | |
| 0032874 | |
| 0006694 | |
| 0008202 | |
| 0016126 | |
| 0006743 | |
| 0043231 | |
| 0016020 | |
| 0010142 | |
| 0045445 | |
| 0045471 | |
| 0008354 | |
| 0008406 | |
| 0005777 | |
| 0008610 | |
| 0005792 | |
| 0005624 |
| PIR ID | A43533 |
|---|---|
| A00356 | |
| S33175 |
| Swiss-Prot ID | HMDH_MOUSE |
|---|---|
| HMDH_HUMAN | |
| HMDH_RAT | |
| Q8BV96_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Endoplasmic reticulum | |
| Peroxisome membrane |
| IPI ID | IPI00469329 |
|---|---|
| IPI00021770 | |
| IPI00221382 | |
| IPI00204259 |
| Mouse chromosome position | 13 49.0 cM |
|---|
| Rat chromosome position | 2q12 |
|---|
| Homologene ID | 30994 |
|---|
| MGI ID | 96159 |
|---|
| RGD ID | 2803 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|