| URN | urn:agi-llid:81727 |
|---|---|
| Total Entities | 0 |
| Connectivity | 0 |
| Name | Mvk |
| Description | mevalonate kinase |
| Notes | kinase that catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate; involved in the cholesterol biosynthetic pathway [RGD] |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| GO Molecular Function | ATP binding |
|---|---|
| mRNA binding | |
| mevalonate kinase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| peroxisome |
| GO Biological Process | negative regulation of translation |
|---|---|
| isoprenoid metabolic process | |
| isopentenyl diphosphate biosynthetic process, mevalonate pathway | |
| isoprenoid biosynthetic process | |
| phosphorylation | |
| negative regulation of inflammatory response | |
| regulation of cholesterol biosynthetic process | |
| cholesterol biosynthetic process | |
| sterol metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| negative regulation of translation | |
| isoprenoid metabolic process | |
| isopentenyl diphosphate biosynthetic process, mevalonate pathway | |
| isoprenoid biosynthetic process | |
| phosphorylation | |
| negative regulation of inflammatory response | |
| regulation of cholesterol biosynthetic process | |
| cholesterol biosynthetic process | |
| sterol metabolic process | |
| ATP binding | |
| mRNA binding | |
| mevalonate kinase activity | |
| cytoplasm | |
| cytosol | |
| peroxisome |
| MedScan ID | 81727 |
|---|
| GenBank ID | NC_005111 |
|---|---|
| NM_031063 | |
| NP_112325 | |
| AC_000080 | |
| CH473973 | |
| EDM13937 | |
| EDM13938 | |
| EDM13939 | |
| M29472 | |
| AAA41588 | |
| P17256 | |
| NW_001084677 |
| LocusLink ID | 81727 |
|---|
| Alias | mevalonate kinase |
|---|---|
| MK |
| Organism | Rattus norvegicus |
|---|
| Unigene ID | Rn.6995 |
|---|
| KEGG ID | rno:81727 |
|---|
| Swiss-Prot Accession | P17256 |
|---|
| EC Number | 2.7.1.36 |
|---|
| GO ID | 0005524 |
|---|---|
| 0003729 | |
| 0004496 | |
| 0006695 | |
| 0019287 | |
| 0008299 | |
| 0006720 | |
| 0050728 | |
| 0017148 | |
| 0016310 | |
| 0045540 | |
| 0016125 | |
| 0005737 | |
| 0005829 | |
| 0005777 | |
| 0000166 | |
| 0016740 | |
| 0008152 | |
| 0005625 | |
| 0042802 |
| PIR ID | A35629 |
|---|
| Swiss-Prot ID | KIME_RAT |
|---|
| Cell Localization | Cytoplasm |
|---|---|
| Peroxisome | |
| Endoplasmic reticulum |
| IPI ID | IPI00214563 |
|---|
| Rat chromosome position | 12 |
|---|
| RGD ID | 621295 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|