| URN | urn:agi-llid:4597 |
|---|---|
| Total Entities | 0 |
| Connectivity | 38 |
| Name | Mvd |
| Description | mevalonate (diphospho) decarboxylase |
| Notes | The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| GO Molecular Function | Hsp70 protein binding |
|---|---|
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| lyase activity | |
| diphosphomevalonate decarboxylase activity |
| GO Cellular Component | peroxisomal matrix |
|---|---|
| cytosol | |
| peroxisome |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| isopentenyl diphosphate biosynthetic process, mevalonate pathway | |
| isoprenoid biosynthetic process | |
| response to drug | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| small molecule metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| positive regulation of cell proliferation | |
| isopentenyl diphosphate biosynthetic process, mevalonate pathway | |
| isoprenoid biosynthetic process | |
| response to drug | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| small molecule metabolic process | |
| Hsp70 protein binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| lyase activity | |
| diphosphomevalonate decarboxylase activity | |
| peroxisomal matrix | |
| cytosol | |
| peroxisome |
| MedScan ID | 4597 |
|---|
| Hugo ID | 7529 |
|---|
| Human chromosome position | 16q24.3 |
|---|
| LocusLink ID | 4597 |
|---|---|
| 192156 | |
| 81726 |
| Alias | MPD |
|---|---|
| FP17780 | |
| diphosphomevalonate decarboxylase | |
| MDDase | |
| mevalonate pyrophosphate decarboxylase | |
| mevalonate pyrophosphate decarboxylase | |
| C78718 | |
| Mvpd | |
| pyrophosphomevalonic acid decarboxylases | |
| mevalonate-5-pyrophosphate decarboxylase | |
| mevalonate-5-pyrophosphate decarboxylases | |
| Mvd | |
| pyrophosphomevalonate decarboxylase | |
| pyrophosphomevalonic acid decarboxylase | |
| pyrophosphomevalonate decarboxylases | |
| 5-pyrophosphomevalonate decarboxylases | |
| mevalonate 5-diphosphate decarboxylases | |
| LOC234837 | |
| mevalonate (diphospho) decarboxylase | |
| mevalonate 5-diphosphate decarboxylase | |
| 5-pyrophosphomevalonate decarboxylase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603236 |
|---|
| Unigene ID | Hs.252457 |
|---|---|
| Mm.28146 | |
| Rn.10288 |
| KEGG ID | hsa:4597 |
|---|---|
| mmu:192156 | |
| rno:81726 |
| Swiss-Prot Accession | P53602 |
|---|---|
| Q3UYC1 | |
| Q99JF5 | |
| Q62967 | |
| Q3TCD8 | |
| Q8BTM4 | |
| Q922D7 | |
| Q53Y65 | |
| Q59G80 | |
| Q6XYE3 | |
| Q642E5 | |
| Q71V32 | |
| Q99PJ4 |
| EC Number | 4.1.1.33 |
|---|
| GO ID | 0005524 |
|---|---|
| 0030544 | |
| 0004163 | |
| 0042803 | |
| 0006695 | |
| 0019287 | |
| 0008299 | |
| 0008284 | |
| 0042493 | |
| 0044281 | |
| 0005829 | |
| 0005777 | |
| 0016829 | |
| 0000166 | |
| 0008203 | |
| 0006629 | |
| 0006694 | |
| 0008202 | |
| 0016126 | |
| 0005782 | |
| 0016301 | |
| 0005625 | |
| 0008610 | |
| 0016310 | |
| 0016740 |
| Swiss-Prot ID | MVD1_MOUSE |
|---|---|
| MVD1_HUMAN | |
| MVD1_RAT | |
| ERG19_HUMAN | |
| ERG19_MOUSE | |
| ERG19_RAT | |
| Q3UYC1_MOUSE |
| Cell Localization | Endoplasmic reticulum |
|---|
| IPI ID | IPI00319950 |
|---|---|
| IPI00022745 | |
| IPI00210317 | |
| IPI00556625 | |
| IPI00428750 | |
| IPI00640007 |
| Mouse chromosome position | 8 |
|---|---|
| 8 E1 |
| Rat chromosome position | 19q12 |
|---|
| Homologene ID | 1843 |
|---|
| MGI ID | 2179327 |
|---|
| RGD ID | 621292 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|