| URN | urn:agi-llid:6713 |
|---|---|
| Total Entities | 0 |
| Connectivity | 108 |
| Name | Sqle |
| Description | squalene epoxidase |
| Notes | Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|---|
| Secreted proteins |
| GO Molecular Function | flavin adenine dinucleotide binding |
|---|---|
| oxidoreductase activity | |
| squalene monooxygenase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| integral to membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | metabolic process |
|---|---|
| cellular aromatic compound metabolic process | |
| response to organic substance | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| metabolic process | |
| cellular aromatic compound metabolic process | |
| response to organic substance | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| flavin adenine dinucleotide binding | |
| oxidoreductase activity | |
| squalene monooxygenase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| integral to membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Secreted proteins |
| MedScan ID | 6713 |
|---|
| Hugo ID | 11279 |
|---|
| Human chromosome position | 8q24.1 |
|---|
| LocusLink ID | 6713 |
|---|---|
| 20775 | |
| 29230 |
| Alias | squalene monooxygenase |
|---|---|
| SE | |
| AI323792 | |
| Erg1 | |
| squalene 2,3-oxidocyclases | |
| squalene-2,3-epoxide cyclase | |
| squalene-2,3-epoxidases | |
| squalene-2,3-epoxidase | |
| squalene oxydocyclases | |
| squalene oxydocyclase | |
| squalene-2,3-epoxide cyclases | |
| squalene epoxidase | |
| squalene 2,3-oxidocyclase | |
| SQLE | |
| FLJ30795 | |
| squalene hydroxylase | |
| squalene hydroxylases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602019 |
|---|
| Unigene ID | Hs.71465 |
|---|---|
| Mm.296169 | |
| Rn.33239 | |
| Mm.218665 |
| KEGG ID | hsa:6713 |
|---|---|
| mmu:20775 | |
| rno:29230 |
| Swiss-Prot Accession | Q14534 |
|---|---|
| Q5HYI4 | |
| Q9UNR6 | |
| P52019 | |
| Q3TQK8 | |
| P52020 | |
| Q4V8L3 | |
| Q9UEK6 | |
| Q3TSS7 | |
| Q8CJ80 |
| EC Number | 1.14.13.132 |
|---|---|
| 1.14.99.7 |
| GO ID | 0050660 |
|---|---|
| 0004506 | |
| 0006725 | |
| 0006695 | |
| 0010033 | |
| 0044281 | |
| 0016126 | |
| 0005789 | |
| 0016021 | |
| 0043231 | |
| 0016491 | |
| 0008203 | |
| 0008152 | |
| 0055114 | |
| 0005783 | |
| 0016020 | |
| 0005792 | |
| 0005615 |
| PIR ID | S52113 |
|---|---|
| A55767 |
| Swiss-Prot ID | ERG1_MOUSE |
|---|---|
| ERG1_RAT | |
| ERG1_HUMAN | |
| Q5HYI4_HUMAN | |
| Q9UNR6_HUMAN | |
| Q3TQK8_MOUSE |
| Cell Localization | Microsome membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Endoplasmic reticulum |
| IPI ID | IPI00122217 |
|---|---|
| IPI00202028 | |
| IPI00291544 | |
| IPI00653256 | |
| IPI00782670 |
| Mouse chromosome position | 15 |
|---|---|
| 15 D1 |
| Rat chromosome position | 7q33 |
|---|
| Homologene ID | 2355 |
|---|
| MGI ID | 109296 |
|---|
| RGD ID | 3755 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|