| URN | urn:agi-llid:4047 |
|---|---|
| Total Entities | 0 |
| Connectivity | 46 |
| Name | Lss |
| Description | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| Notes | The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Two transcript variants encoding the same protein have been found for this gene. |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| isomerase activity | |
| intramolecular transferase activity | |
| lanosterol synthase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| lipid particle | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | lipid metabolic process |
|---|---|
| steroid metabolic process | |
| steroid biosynthetic process | |
| cholesterol biosynthetic process | |
| sterol metabolic process | |
| small molecule metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| cholesterol biosynthetic process | |
| sterol metabolic process | |
| small molecule metabolic process | |
| catalytic activity | |
| isomerase activity | |
| intramolecular transferase activity | |
| lanosterol synthase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| lipid particle | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| MedScan ID | 4047 |
|---|
| Hugo ID | 6708 |
|---|
| Human chromosome position | 21q22.3 |
|---|
| LocusLink ID | 4047 |
|---|---|
| 16987 | |
| 81681 |
| Alias | OSC |
|---|---|
| lanosterol synthase | |
| hOSC | |
| oxidosqualene--lanosterol cyclase | |
| 2,3-epoxysqualene-lanosterol cyclase | |
| 2,3-epoxysqualene--lanosterol cyclase | |
| BC029082 | |
| D10Ertd116e | |
| 2810025N20Rik | |
| 2,3-oxidosqualene: lanosterol cyclase | |
| Lss | |
| human lanosterol synthase | |
| human lanosterol synthetase | |
| lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | |
| Lanosterol synthetase | |
| lanosterol synthetase (2,3-oxidosqualene-lanosterol cyclase) | |
| MGC27893 | |
| LOC497745 | |
| LOC360327 | |
| FLJ46393 | |
| FLJ39450 | |
| FLJ35015 | |
| FLJ25486 | |
| Oxidosqualene-lanosterol cyclase | |
| 2810025N20 | |
| DNA segment, Chr 10, ERATO Doi 116, expressed | |
| RIKEN cDNA 2810025N20 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600909 |
|---|
| Unigene ID | Hs.596543 |
|---|---|
| Mm.55075 | |
| Rn.10211 | |
| Hs.708002 |
| KEGG ID | hsa:4047 |
|---|---|
| mmu:16987 | |
| rno:81681 |
| Swiss-Prot Accession | B2R694 |
|---|---|
| P48449 | |
| B4DJZ9 | |
| E9PEI9 | |
| G5E9Q9 | |
| Q8BLN5 | |
| P48450 | |
| Q8BVJ4 | |
| Q8K307 | |
| Q62811 | |
| D3DSN0 | |
| Q8IYL6 | |
| Q9UEZ1 | |
| Q6ZQP6 | |
| Q8N7J1 | |
| Q8N8I2 | |
| Q8NAP6 | |
| Q8VCN8 |
| EC Number | 5.4.99.7 |
|---|
| GO ID | 0000250 |
|---|---|
| 0006695 | |
| 0044281 | |
| 0008202 | |
| 0005789 | |
| 0005811 | |
| 0003824 | |
| 0016866 | |
| 0016853 | |
| 0006629 | |
| 0006694 | |
| 0016125 | |
| 0005783 | |
| 0043231 | |
| 0016020 | |
| 0005792 | |
| 0008610 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0016829 | |
| 0008152 |
| PIR ID | JC4194 |
|---|
| Swiss-Prot ID | ERG7_MOUSE |
|---|---|
| ERG7_RAT | |
| ERG7_HUMAN | |
| B4DJZ9_HUMAN | |
| D3DSN0_HUMAN | |
| B2R694_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Endoplasmic reticulum |
| IPI ID | IPI00169958 |
|---|---|
| IPI00566093 | |
| IPI00009747 | |
| IPI00384606 | |
| IPI00871623 | |
| IPI00792647 | |
| IPI00791839 | |
| IPI00475419 | |
| IPI00880519 |
| Mouse chromosome position | 10 41.1 cM |
|---|
| Rat chromosome position | 20p12 |
|---|
| Homologene ID | 37408 |
|---|
| MGI ID | 1336155 |
|---|
| RGD ID | 620955 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|