| URN | urn:agi-llid:2224 |
|---|---|
| Total Entities | 0 |
| Connectivity | 177 |
| Name | Fdps |
| Description | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) |
| Notes | The isoprene biosynthetic pathway provides the cell with cholesterol, ubiquinone, dolichol, and other nonsterol metabolites. Farnesylpyrophosphate synthetase (EC 2.5.1.10) catalyzes the formation of both geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate.[supplied by OMIM] |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| transferase activity | |
| geranyltranstransferase activity | |
| farnesyltranstransferase activity | |
| dimethylallyltranstransferase activity |
| GO Cellular Component | nucleolus |
|---|---|
| mitochondrial matrix | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| peroxisome | |
| nucleus |
| GO Biological Process | virus-host interaction |
|---|---|
| positive regulation of cell growth involved in cardiac muscle cell development | |
| farnesyl diphosphate biosynthetic process | |
| geranyl diphosphate biosynthetic process | |
| isoprenoid biosynthetic process | |
| cellular response to fatty acid | |
| response to drug | |
| response to peptide hormone stimulus | |
| response to testosterone stimulus | |
| response to cholesterol | |
| positive regulation of cholesterol biosynthetic process | |
| male gonad development | |
| spermatogenesis | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| small molecule metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| virus-host interaction | |
| positive regulation of cell growth involved in cardiac muscle cell development | |
| farnesyl diphosphate biosynthetic process | |
| geranyl diphosphate biosynthetic process | |
| isoprenoid biosynthetic process | |
| cellular response to fatty acid | |
| response to drug | |
| response to peptide hormone stimulus | |
| response to testosterone stimulus | |
| response to cholesterol | |
| positive regulation of cholesterol biosynthetic process | |
| male gonad development | |
| spermatogenesis | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| small molecule metabolic process | |
| metal ion binding | |
| transferase activity | |
| geranyltranstransferase activity | |
| farnesyltranstransferase activity | |
| dimethylallyltranstransferase activity | |
| nucleolus | |
| mitochondrial matrix | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| peroxisome | |
| nucleus |
| MedScan ID | 2224 |
|---|
| Hugo ID | 3631 |
|---|
| Human chromosome position | 1q22 |
|---|
| LocusLink ID | 2224 |
|---|---|
| 110196 | |
| 83791 |
| Alias | FPS |
|---|---|
| FPPS | |
| farnesyl pyrophosphate synthase | |
| FPP synthase | |
| FPP synthetase | |
| geranyltranstransferase | |
| dimethylallyltranstransferase | |
| (2E,6E)-farnesyl diphosphate synthase | |
| farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase | |
| Fdpsl1 | |
| AI256750 | |
| mKIAA1293 | |
| 6030492I17Rik | |
| CR 39 | |
| farnesyl diphosphate synthase | |
| farnesyl pyrophosphate synthetase | |
| cholesterol-regulated 39 kDa protein | |
| Ac2-125 | |
| farnesyl diphosphate synthetase | |
| testis-specific farnesyl pyrophosphate synthetase | |
| farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | |
| KIAA1293 | |
| Fdps | |
| FPPase | |
| MGC107162 | |
| OTTHUMP00000015807 | |
| OTTHUMP00000015808 | |
| testis-specific farnesyl pyrophosphate synthase | |
| Fdpsl I | |
| 6030492I17 | |
| farensyl diphosphate synthase | |
| farnesyldiphosphate synthase | |
| farnesyldiphosphate synthetase | |
| RIKEN cDNA 6030492I17 gene | |
| Fdpsl1s | |
| Fdpsl Is | |
| Farnesyl diphosphate synthetase | |
| expressed sequence AI256750 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 134629 |
|---|
| Unigene ID | Hs.335918 |
|---|---|
| Mm.39472 | |
| Mm.490094 | |
| Rn.2848 |
| KEGG ID | hsa:2224 |
|---|---|
| mmu:110196 | |
| rno:83791 |
| Swiss-Prot Accession | P14324 |
|---|---|
| E9PCI9 | |
| Q920E5 | |
| Q4FJN9 | |
| P05369 | |
| D3DV91 | |
| Q96G29 | |
| Q6GT82 | |
| Q3TMB3 | |
| Q3US29 | |
| Q5M8R9 | |
| Q7TPK0 |
| EC Number | 2.5.1.10 |
|---|---|
| 2.5.1.1 |
| GO ID | 0004161 |
|---|---|
| 0004337 | |
| 0046872 | |
| 0006695 | |
| 0045337 | |
| 0033384 | |
| 0044281 | |
| 0019048 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005730 | |
| 0005634 | |
| 0004311 | |
| 0016740 | |
| 0008203 | |
| 0008299 | |
| 0006629 | |
| 0061051 | |
| 0045542 | |
| 0006694 | |
| 0008202 | |
| 0016126 | |
| 0005759 | |
| 0005777 | |
| 0071398 | |
| 0008584 | |
| 0070723 | |
| 0042493 | |
| 0043434 | |
| 0033574 | |
| 0007283 | |
| 0044419 | |
| 0008610 | |
| 0030307 | |
| 0005625 | |
| 0000287 |
| PIR ID | A35726 |
|---|---|
| A34713 | |
| B34713 |
| Swiss-Prot ID | FPPS_MOUSE |
|---|---|
| FPPS_HUMAN | |
| FPPS_RAT | |
| Q4FJN9_MOUSE | |
| D3DV91_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum |
| IPI ID | IPI00120457 |
|---|---|
| IPI00914566 | |
| IPI00325147 | |
| IPI00914971 | |
| IPI00569697 | |
| IPI00564311 |
| Mouse chromosome position | 3 42.6 cM |
|---|
| Rat chromosome position | 2q34 |
|---|
| Homologene ID | 1519 |
|---|
| MGI ID | 104888 |
|---|
| RGD ID | 68953 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|