| URN | urn:agi-llid:3422 |
|---|---|
| Total Entities | 0 |
| Connectivity | 37 |
| Name | Idi1 |
| Description | isopentenyl-diphosphate delta isomerase 1 |
| Notes | IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. |
| Ariadne Ontology | Cholesterol-isoprenoid metabolism |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| magnesium ion binding | |
| manganese ion binding | |
| isomerase activity | |
| hydrolase activity | |
| isopentenyl-diphosphate delta-isomerase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| cytosol | |
| peroxisome |
| GO Biological Process | dimethylallyl diphosphate biosynthetic process |
|---|---|
| isoprenoid biosynthetic process | |
| response to stilbenoid | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| small molecule metabolic process |
| Pathway | cholesterol biosynthetic pathway |
|---|---|
| cholesterol biosynthetic pathway |
| Group | Cholesterol-isoprenoid metabolism |
|---|---|
| dimethylallyl diphosphate biosynthetic process | |
| isoprenoid biosynthetic process | |
| response to stilbenoid | |
| lipid metabolic process | |
| steroid metabolic process | |
| steroid biosynthetic process | |
| sterol biosynthetic process | |
| cholesterol biosynthetic process | |
| cholesterol metabolic process | |
| small molecule metabolic process | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| isomerase activity | |
| hydrolase activity | |
| isopentenyl-diphosphate delta-isomerase activity | |
| mitochondrion | |
| cytosol | |
| peroxisome |
| MedScan ID | 3422 |
|---|
| Hugo ID | 5387 |
|---|
| Human chromosome position | 10p15.3 |
|---|
| LocusLink ID | 3422 |
|---|---|
| 319554 | |
| 89784 |
| Alias | IPP1 |
|---|---|
| IPPI1 | |
| isopentenyl-diphosphate Delta-isomerase 1 | |
| IPP isomerase 1 | |
| isopentenyl pyrophosphate isomerase 1 | |
| isopentenyl diphosphate dimethylallyl diphosphate isomerase 1 | |
| 4832416K17Rik | |
| isopentenyl-diphosphate delta isomerase 1 | |
| MGC108635 | |
| MGC118013 | |
| OTTHUMP00000018949 | |
| Isopentenyl pyrophosphate isomerase | |
| OTTHUMP00000018951 | |
| MGC8139 | |
| IPP isomerase | |
| IDI1 | |
| IDI I | |
| 4832416K17 | |
| isopentenyl-diphosphate delta isomerase | |
| isopentenyl-diphosphate delta isomerase, isoform 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604055 |
|---|
| Unigene ID | Hs.741176 |
|---|---|
| Mm.29847 | |
| Rn.10780 | |
| Rn.165929 | |
| Hs.283652 | |
| Mm.426406 | |
| Hs.705849 | |
| Hs.705628 |
| KEGG ID | hsa:3422 |
|---|---|
| mmu:319554 | |
| rno:89784 |
| Swiss-Prot Accession | Q13907 |
|---|---|
| G3XA48 | |
| P58044 | |
| O35760 | |
| B4E155 | |
| Q32Q13 | |
| Q53GQ6 | |
| Q86U81 | |
| Q8WUX8 | |
| Q96IZ4 | |
| Q9BQ74 | |
| Q4FJU2 | |
| Q5FVT3 |
| EC Number | 5.3.3.2 |
|---|
| GO ID | 0016787 |
|---|---|
| 0004452 | |
| 0000287 | |
| 0030145 | |
| 0046872 | |
| 0006695 | |
| 0050992 | |
| 0008299 | |
| 0035634 | |
| 0044281 | |
| 0005829 | |
| 0005739 | |
| 0005777 | |
| 0016853 | |
| 0008203 | |
| 0006629 | |
| 0006694 | |
| 0008202 | |
| 0016126 | |
| 0016117 | |
| 0008610 |
| Swiss-Prot ID | IDI1_HUMAN |
|---|---|
| IDI1_MOUSE | |
| IDI1_RAT | |
| B4E155_HUMAN |
| Cell Localization | Peroxisome |
|---|---|
| Endoplasmic reticulum |
| IPI ID | IPI00220014 |
|---|---|
| IPI00645307 | |
| IPI00987185 | |
| IPI00212309 | |
| IPI00640997 | |
| IPI00115850 | |
| IPI00360191 |
| Mouse chromosome position | 13 |
|---|---|
| 13 A1 |
| Rat chromosome position | 17q12.1 |
|---|
| Homologene ID | 3315 |
|---|
| MGI ID | 2442264 |
|---|
| RGD ID | 621835 |
|---|
| Primary Cell Localization | Endoplasmic reticulum |
|---|