Protein Hmgcs1

URN	urn:agi-llid:3157
Total Entities	0
Connectivity	43
Name	Hmgcs1
Description	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
Notes	catalyzes the conversion of (S)-3-hydroxy-3-methylglutaryl-CoA and CoA to acetyl-CoA, acetoacetyl-CoA, and H2O [RGD]

Ariadne Ontology	Branched amino acid metabolism
	Cholesterol-isoprenoid metabolism

GO Molecular Function	catalytic activity
	drug binding
	protein homodimerization activity
	organic acid binding
	isomerase activity
	transferase activity
	hydroxymethylglutaryl-CoA synthase activity

GO Biological Process	metabolic process
	cellular lipid metabolic process
	isoprenoid biosynthetic process
	cellular response to organic cyclic compound
	cellular response to follicle-stimulating hormone stimulus
	cellular response to cholesterol
	response to drug
	response to acid
	response to tellurium ion
	response to organic nitrogen
	response to organic cyclic compound
	response to hormone stimulus
	response to lipoprotein particle stimulus
	response to gonadotropin stimulus
	response to vitamin E
	response to cholesterol
	response to purine-containing compound
	response to low light intensity stimulus
	male gonad development
	brain development
	liver development
	lipid metabolic process
	steroid metabolic process
	steroid biosynthetic process
	sterol biosynthetic process
	cholesterol biosynthetic process
	cholesterol metabolic process
	small molecule metabolic process

Pathway	cholesterol biosynthetic pathway
	ketone bodies metabolic pathway
	ketone bodies metabolic pathway
	ketone bodies metabolic pathway
	cholesterol biosynthetic pathway

Group	Branched amino acid metabolism
	Cholesterol-isoprenoid metabolism
	metabolic process
	cellular lipid metabolic process
	isoprenoid biosynthetic process
	cellular response to organic cyclic compound
	cellular response to follicle-stimulating hormone stimulus
	cellular response to cholesterol
	response to drug
	response to acid
	response to tellurium ion
	response to organic nitrogen
	response to organic cyclic compound
	response to hormone stimulus
	response to lipoprotein particle stimulus
	response to gonadotropin stimulus
	response to vitamin E
	response to cholesterol
	response to purine-containing compound
	response to low light intensity stimulus
	male gonad development
	brain development
	liver development
	lipid metabolic process
	steroid metabolic process
	steroid biosynthetic process
	sterol biosynthetic process
	cholesterol biosynthetic process
	cholesterol metabolic process
	small molecule metabolic process
	catalytic activity
	drug binding
	protein homodimerization activity
	organic acid binding
	isomerase activity
	transferase activity
	hydroxymethylglutaryl-CoA synthase activity
	nucleolus
	plasma membrane
	cytoplasm
	cytosol
	nucleus

MedScan ID	3157

Hugo ID	5007

Human chromosome position	5p14-p13

Alias	HMGCS
	hydroxymethylglutaryl-CoA synthase, cytoplasmic
	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase
	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
	B130032C06Rik
	HMG-CoA synthase
	3-hydroxy-3-methylglutaryl coenzyme A synthase
	hydroxymethylglutaryl-CoA synthase 1
	MGC36662
	Hmgcs I
	Hmgcs1
	Hydroxymethylglutaryl-CoA synthase I
	Hydroxymethylglutaryl-CoA synthetase 1
	Hydroxymethylglutaryl-CoA synthetase I
	MGC98430
	LOC100040592
	MGC90332
	HMG-CoA synthase I
	Hydroxymethylglutaryl-CoA synthetase, cytoplasmic
	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
	HMG-CoA synthetase I
	HMG-CoA synthetase 1
	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
	3-hydroxy-3-methylglutaryl-Coenzyme A synthase I
	3-hydroxy-3-methylglutaryl-Coenzyme A synthetase 1
	3-hydroxy-3-methylglutaryl-Coenzyme A synthetase 1 (soluble)
	3-hydroxy-3-methylglutaryl-Coenzyme A synthetase I
	B130032C06
	HMG-CoA synthase 1
	similar to Hmgcs1 protein
	Hmgcs1s
	ectodermal dysplasia, anhidrotic (hypohydrotic)
	EDA1
	tabby
	XLHED
	EDA protein homolog
	ectodysplasin-A isoform Ta C
	Ectodysplasin A
	XHED
	EDA I
	Eda-A1
	Eda-A2
	Eda-A1s
	Eda-A2s
	Hmgcs Is
	Ectodermal dysplasia protein
	ED1 protein
	ED I
	HED
	Eda

OMIM ID	142940

EC Number	2.3.3.10
	4.1.3.5

Cell Localization	Cytoplasm
	Endoplasmic reticulum

Mouse chromosome position	13 66.0 cM
	13

Rat chromosome position	2q16

MGI ID	107592

RGD ID	70970

Primary Cell Localization	Cytoplasm
	Endoplasmic reticulum